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Nr3c1 Gene Detail
Summary
  • Symbol
    Nr3c1
  • Name
    nuclear receptor subfamily 3, group C, member 1
  • Synonyms
    glucocorticoid receptor, GR, Grl1, Grl-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95824
    NCBI Gene: 14815
  • Gene Overview
    MyGene.info: NR3C1
Location & Maps
more
  • Sequence Map
    Chr18:39410545-39491301 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      80757 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 21.09 cM
  • Mapping Data
    30 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    NR3C1, nuclear receptor subfamily 3 group C member 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NR3C1, nuclear receptor subfamily 3 group C member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GCCR, GCR, GCRST, GR, GRL
  • Links
    NCBI Gene ID: 2908
    neXtProt AC: NX_P04150
    UniProt: P04150

  • Chr Location
    5q31.3; chr5:143277931-143435512 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Nr3c1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    138 phenotypes from 13 alleles in 23 genetic backgrounds
    2 phenotypes from multigenic genotypes
    1 images
    155 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants die at birth of respiratory failure with underdeveloped lungs, enlarged adrenals, elevated serum corticosterone and ACTH, and failed adrenaline synthesis. Mice with a point mutation have impaired gluconeogenesis and erythropoiesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023975 VEGA Gene Model | MGI Sequence Detail 80757 C57BL/6J ±  kb
transcript OTTMUST00000058601 VEGA | MGI Sequence Detail 2382 Not Applicable  
polypeptide OTTMUSP00000028423 VEGA | MGI Sequence Detail 793 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    588 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 163
    Genomic 14
    cDNA 141
    Primer pair 8

    Microarray probesets 10
Other
Accession IDs
less
MGD-MRK-10262, MGD-MRK-10263
References
more
  • Summaries
    All 323
    Developmental Gene Expression 54
    Diseases 1
    Gene Ontology 24
    Phenotypes 155
  • Earliest
    J:6459 Francke U, et al., Chromosome assignment of a murine glucocorticoid receptor gene (Grl-1) using intraspecies somatic cell hybrids. Cell. 1980 Dec;22(3):657-64
  • Latest
    J:239538 Engler JB, et al., Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy. Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E181-E190

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/15/2017
MGI 6.10
The Jackson Laboratory