About   Help   FAQ
Nr3c1
Gene Detail
Symbol

Name
ID
Nr3c1
nuclear receptor subfamily 3, group C, member 1
MGI:95824
STS
Synonyms
glucocorticoid receptor, GR, Grl1, Grl-1
Feature Type
protein coding gene
Genetic Map
Chromosome 18
21.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)
Sequence Map
Chr18:39410545-39491301 bp, - strand
From VEGA annotation of GRCm38

  80757 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30960  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NR3C1
Protein SuperFamily: glucocorticoid receptor
Gene Tree: Nr3c1

Human
homologs
NR3C1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2908
neXtProt AC: NX_P04150

Human Synonyms: GCCR, GCR, GCRST, GR, GRL

Human Chr (Location): 5q31.3; chr5:143277931-143435512 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NR3C1

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(1) Targeted(15)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants die at birth of respiratory failure with underdeveloped lungs, enlarged adrenals, elevated serum corticosterone and ACTH, and failed adrenaline synthesis. Mice with a point mutation have impaired gluconeogenesis and erythropoiesis.
 
Phenotype Images(1)
Interactions
Nr3c1 interacts with 455 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (86 annotations)
Process adrenal gland development, cellular response to dexamethasone stimulus, ...
Component cytoplasm, cytosol, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (51 records)
Data Summary: Results (240)    Tissues (166)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 149
Northern blot 18
Western blot 46
RT-PCR 26
cDNA source data(139)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase nr3c1 ; ZFIN nr3c1    NEW 
Molecular
reagents
All nucleic(161) Genomic(14) cDNA(140) Primer pair(7)
Microarray probesets(10)
Other database
links
VEGA Gene Model OTTMUSG00000023975 (Evidence)
Ensembl Gene Model ENSMUSG00000024431 (Evidence)
Entrez Gene 14815 (Evidence)
UniGene 129481
DFCI TC1575767, TC1643837, TC1654882, TC1664672, TC1673805, TC1721538
DoTS DT.101309837, DT.493344, DT.91401091, DT.99867367
NIA Mouse Gene Index U038364
PDB 3MNE, 3MNO, 3MNP
Consensus CDS Project CCDS37791.1
International Mouse Phenotyping Consortium Status Nr3c1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023975 VEGA Gene Model | MGI Sequence Detail 80757 C57BL/6J ±  kb
transcript OTTMUST00000058601 VEGA | MGI Sequence Detail 2382 Not Applicable 
polypeptide OTTMUSP00000028423 VEGA | MGI Sequence Detail 793 Not Applicable 

For the selected sequences
All sequences(100) RefSeq(20) UniProt(12)
Polymorphisms
RFLP(6) : SNPs within 2kb(420 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001409 Glucocorticoid receptor
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011406 glucocorticoid receptor
References
(Earliest) J:6459 Francke U, et al., Chromosome assignment of a murine glucocorticoid receptor gene (Grl-1) using intraspecies somatic cell hybrids. Cell. 1980 Dec;22(3):657-64
(Latest) J:221159 Stubbusch J, et al., Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance. Dev Biol. 2015 Apr 15;400(2):210-23
All references(290)
Other
accession IDs
MGD-MRK-10262, MGD-MRK-10263

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory