Nr3c1
Gene Detail

Symbol Name ID

Nr3c1 nuclear receptor subfamily 3, group C, member 1 MGI:95824

STS

D18Mit17

Synonyms

glucocorticoid receptor, GR, Grl1, Grl-1

Feature Type

protein coding gene

Genetic Map

Chromosome 18

21.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)

Sequence Map

Chr18:39410545-39491301 bp, - strand From VEGA annotation of GRCm38   80757 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; guinea pig    (Mammalian Orthology)
Comparative Map (Mouse/Human Nr3c1 ± 2 cM)

Protein SuperFamily: glucocorticoid receptor
Gene Tree: Nr3c1

Human ortholog

NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) NCBI Gene ID 2908
Human Synonyms: GCCR, GCR, GR, GRL
Human Chr5:142657496-142815077 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human NR3C1 (1)

Alleles and phenotypes

All alleles(14) : Targeted(13) Gene trapped(1)
 

Homozygous null mutants die at birth of respiratory failure with underdeveloped lungs, enlarged adrenals, elevated serum corticosterone and ACTH, and failed adrenaline synthesis. Mice with a point mutation have impaired gluconeogenesis and erythropoiesis.

 
Human Diseases Modeled Using Mouse Nr3c1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (69 annotations)

Process	adrenal gland development, cellular response to dexamethasone stimulus, ...
Component	cytoplasm, cytosol, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (45 records)
Data Summary: Results (234)    Tissues (162)    Images (18)
Theiler Stages: 2, 3, 4, 5, 14, 15, 17, 19, 20, 21, 22, 23, 26, 28

Assay Type	Results
RNA in situ	151
Northern blot	18
Western blot	34
RT-PCR	31

cDNA source data(136)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(157) Genomic(14) cDNA(137) Primer pair(6)
Microarray probesets(10)

Other database links

VEGA Gene Model	OTTMUSG00000023975 (Evidence)
Ensembl Gene Model	ENSMUSG00000024431 (Evidence)
Entrez Gene	14815 (Evidence)
UniGene	129481
DFCI	TC1575767, TC1643837, TC1654882, TC1664672, TC1673805, TC1721538
DoTS	DT.101309837, DT.493344, DT.91401091, DT.99867367
NIA Mouse Gene Index	U038364
PDB	3MNE, 3MNO, 3MNP
Consensus CDS Project	CCDS37791.1
International Mouse Knockout Project Status	Nr3c1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023975	VEGA Gene Model | MGI Sequence Detail	80757	C57BL/6J
transcript	OTTMUST00000058601	VEGA | MGI Sequence Detail	2382	Not Applicable
polypeptide	OTTMUSP00000028423	VEGA | MGI Sequence Detail	793	Not Applicable

All sequences(82) RefSeq(2) UniProt(12)

Polymorphisms

RFLP(6) : SNPs(369 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001409	Glucocorticoid receptor
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000011406	glucocorticoid receptor

References

(Earliest) J:6459 Francke U, et al., Chromosome assignment of a murine glucocorticoid receptor gene (Grl-1) using intraspecies somatic cell hybrids. Cell. 1980 Dec;22(3):657-64
(Latest) J:192525 Goodwin JE, et al., Endothelial glucocorticoid receptor is required for protection against sepsis. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):306-11
All references(260)

Other accession IDs

MGD-MRK-10262, MGD-MRK-10263