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Nr3c1
Gene Detail
Symbol

Name
ID
Nr3c1
nuclear receptor subfamily 3, group C, member 1
MGI:95824
STS
Synonyms
glucocorticoid receptor, GR, Grl1, Grl-1
Feature Type
protein coding gene
Genetic Map
Chromosome 18
21.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)
Sequence Map
Chr18:39410545-39491301 bp, - strand
From VEGA annotation of GRCm38

  80757 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30960  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: glucocorticoid receptor
Gene Tree: Nr3c1

Human
homologs
Human Homolog NR3C1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NCBI Gene ID 2908
neXtProt AC  NX_P04150
Human Synonyms  GCCR, GCR, GCRST, GR, GRL
Human Chr (Location)  5q31.3; chr5:143277931-143733756 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NR3C1
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(1) Targeted(14)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants die at birth of respiratory failure with underdeveloped lungs, enlarged adrenals, elevated serum corticosterone and ACTH, and failed adrenaline synthesis. Mice with a point mutation have impaired gluconeogenesis and erythropoiesis.
 
Phenotype Images(1)
Interactions
Nr3c1 interacts with 455 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (86 annotations)
Process adrenal gland development, cellular response to dexamethasone stimulus, ...
Component cytoplasm, cytosol, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (50 records)
Data Summary: Results (227)    Tissues (166)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 151
Northern blot 18
Western blot 34
RT-PCR 24
cDNA source data(139)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(160) Genomic(14) cDNA(140) Primer pair(6)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000023975 (Evidence)
Ensembl Gene ModelENSMUSG00000024431 (Evidence)
Entrez Gene14815 (Evidence)
UniGene129481
DFCITC1575767, TC1643837, TC1654882, TC1664672, TC1673805, TC1721538
DoTSDT.101309837, DT.493344, DT.91401091, DT.99867367
NIA Mouse Gene IndexU038364
PDB3MNE, 3MNO, 3MNP
Consensus CDS ProjectCCDS37791.1
International Mouse Knockout Project StatusNr3c1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023975 VEGA Gene Model | MGI Sequence Detail 80757 C57BL/6J ±  kb
transcript OTTMUST00000058601 VEGA | MGI Sequence Detail 2382 Not Applicable 
polypeptide OTTMUSP00000028423 VEGA | MGI Sequence Detail 793 Not Applicable 

For the selected sequences
All sequences(111) RefSeq(20) UniProt(23)
Polymorphisms
RFLP(6) : SNPs within 2kb(420 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001409 Glucocorticoid receptor
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011406 glucocorticoid receptor
References
(Earliest) J:6459 Francke U, et al., Chromosome assignment of a murine glucocorticoid receptor gene (Grl-1) using intraspecies somatic cell hybrids. Cell. 1980 Dec;22(3):657-64
(Latest) J:209571 Goriki A, et al., A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol. 2014 Apr;12(4):e1001839
All references(286)
Other
accession IDs
MGD-MRK-10262, MGD-MRK-10263

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory