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Grin2d Gene Detail
Summary
  • Symbol
    Grin2d
  • Name
    glutamate receptor, ionotropic, NMDA2D (epsilon 4)
  • Synonyms
    GluN2D, GluRepsilon4, NMDAR2D, NR2D
  • Feature Type
    protein coding gene
  • IDs
    MGI:95823
    NCBI Gene: 14814
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45481307-45520708 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.54 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    366 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95823
protein coding gene Chr7:45481307-45527802 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032251
protein coding gene Chr7:46153787-46195569 (-)
A/J MGP_AJ_G0032230
protein coding gene Chr7:45230619-45269642 (-)
AKR/J MGP_AKRJ_G0032166
protein coding gene Chr7:46501778-46542660 (-)
BALB/cJ MGP_BALBcJ_G0032242
protein coding gene Chr7:45230244-45269658 (-)
C3H/HeJ MGP_C3HHeJ_G0031957
protein coding gene Chr7:46985477-47024912 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032734
protein coding gene Chr7:48418668-48459595 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029748
protein coding gene Chr7:47781026-47820484 (-)
CAST/EiJ MGP_CASTEiJ_G0031285
protein coding gene Chr7:38429163-38471212 (-)
CBA/J MGP_CBAJ_G0031922
protein coding gene Chr7:50036125-50085806 (-)
DBA/2J MGP_DBA2J_G0032079
protein coding gene Chr7:44910129-44949743 (-)
FVB/NJ MGP_FVBNJ_G0032031
protein coding gene Chr7:44686589-44729201 (-)
LP/J MGP_LPJ_G0032158
protein coding gene Chr7:46861089-46904437 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032068
protein coding gene Chr7:48711763-48754809 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032749
protein coding gene Chr7:45705026-45744616 (-)
PWK/PhJ MGP_PWKPhJ_G0031008
protein coding gene Chr7:38280705-38320356 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030846
protein coding gene Chr7:33737122-33772568 (-)
WSB/EiJ MGP_WSBEiJ_G0031403
protein coding gene Chr7:46203013-46247821 (-)



Homology
more
  • Human Ortholog
    GRIN2D, glutamate ionotropic receptor NMDA type subunit 2D
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIN2D, glutamate ionotropic receptor NMDA type subunit 2D
  • Synonyms
    DEE46, EB11, EIEE46, GluN2D, NMDAR2D, NR2D
  • Links
    NCBI Gene ID: 2906
    neXtProt AC: NX_O15399
    UniProt: O15399

  • Chr Location
    19q13.33; chr19:48393668-48444931 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human GRIN2D associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced spontaneous activity and an elevated auditory brainstem response threshold.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14814 NCBI Gene Model | MGI Sequence Detail 39402 C57BL/6J ±  kb
    transcript NM_008172 RefSeq | MGI Sequence Detail 5395 ZRU/MplStud  
    polypeptide Q03391 UniProt | EBI | MGI Sequence Detail 1323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008249 glutamate receptor ionotropic, NMDA 2D
    • InterPro Domains
      IPR015683 Ionotropic glutamate receptor
      IPR001320 Ionotropic glutamate receptor, C-terminal
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
      IPR001638 Solute-binding protein family 3/N-terminal domain of MltF
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 5
      cDNA 20
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10261
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 12
      Gene Ontology 14
      Phenotypes 38
    • Earliest
      J:3203 Ikeda K, et al., Cloning and expression of the epsilon 4 subunit of the NMDA receptor channel. FEBS Lett. 1992 Nov 16;313(1):34-8
    • Latest
      J:338196 Gawande DY, et al., GluN2D Subunit in Parvalbumin Interneurons Regulates Prefrontal Cortex Feedforward Inhibitory Circuit and Molecular Networks Relevant to Schizophrenia. Biol Psychiatry. 2023 Mar 31;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory