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Grin2d Gene Detail
Summary
  • Symbol
    Grin2d
  • Name
    glutamate receptor, ionotropic, NMDA2D (epsilon 4)
  • Synonyms
    GluN2D, GluRepsilon4, NMDAR2D, NR2D
  • Feature Type
    protein coding gene
  • IDs
    MGI:95823
    NCBI Gene: 14814
  • Gene Overview
    MyGene.info: GRIN2D
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:45831883-45878378 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46496 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.54 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    GRIN2D, glutamate ionotropic receptor NMDA type subunit 2D
  • Vertebrate Orthologs
    6
  • Human Ortholog
    GRIN2D, glutamate ionotropic receptor NMDA type subunit 2D
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EB11, EIEE46, GluN2D, NMDAR2D, NR2D
  • Links
    NCBI Gene ID: 2906
    neXtProt AC: NX_O15399
    UniProt: O15399

  • Chr Location
    19q13.33; chr19:48394875-48444937 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced spontaneous activity and an elevated auditory brainstem response threshold.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022308 VEGA Gene Model | MGI Sequence Detail 46496 C57BL/6J ±  kb
    transcript OTTMUST00000053152 VEGA | MGI Sequence Detail 5431 Not Applicable  
    polypeptide OTTMUSP00000025256 VEGA | MGI Sequence Detail 1323 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      454 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008249 glutamate receptor ionotropic, NMDA 2D
    • InterPro Domains
      IPR001320 Ionotropic glutamate receptor
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    Molecular
    Reagents
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    • All nucleic 27
      Genomic 5
      cDNA 20
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10261
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 11
      Gene Ontology 12
      Phenotypes 25
    • Earliest
      J:3203 Ikeda K, et al., Cloning and expression of the epsilon 4 subunit of the NMDA receptor channel. FEBS Lett. 1992 Nov 16;313(1):34-8
    • Latest
      J:242531 Bedogni F, et al., Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms. Cereb Cortex. 2016 Jun;26(6):2517-2529

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory