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Grin2d
Gene Detail
Symbol

Name
ID
Grin2d
glutamate receptor, ionotropic, NMDA2D (epsilon 4)
MGI:95823
Synonyms
GluN2D, GluRepsilon4, NMDAR2D, NR2D
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:45831883-45870928 bp, - strand
From VEGA annotation of GRCm38

  39046 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:648  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Grin2d

Human
homologs
Human Homolog GRIN2D, glutamate receptor, ionotropic, N-methyl D-aspartate 2D
NCBI Gene ID 2906
neXtProt AC  NX_O15399
Human Synonyms  EB11, GluN2D, NMDAR2D, NR2D
Human Chr (Location)  19q13.33; chr19:48394875-48444931 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit reduced spontaneous activity and an elevated auditory brainstem response threshold.
 
Interactions
Grin2d interacts with 140 markers (Mir17, Mir19a, Mir20a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (9)    Tissues (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
RT-PCR 8
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(4) cDNA(20) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022308 (Evidence)
Ensembl Gene ModelENSMUSG00000002771 (Evidence)
Entrez Gene14814 (Evidence)
UniGene322594
DFCITC1604198
DoTSDT.40183841
NIA Mouse Gene IndexU028546
Consensus CDS ProjectCCDS21267.1
International Mouse Knockout Project StatusGrin2d
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022308 VEGA Gene Model | MGI Sequence Detail 39046 C57BL/6J ±  kb
transcript OTTMUST00000053152 VEGA | MGI Sequence Detail 5431 Not Applicable 
polypeptide OTTMUSP00000025256 VEGA | MGI Sequence Detail 1323 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(12) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(368 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR001638 Extracellular solute-binding protein, family 3
InterPro IPR019594 Glutamate receptor, L-glutamate/glycine-binding
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR001508 NMDA receptor
Protein Ontology PR:000008249 glutamate receptor ionotropic, NMDA 2D
References
(Earliest) J:3203 Ikeda K, et al., Cloning and expression of the epsilon 4 subunit of the NMDA receptor channel. FEBS Lett. 1992 Nov 16;313(1):34-8
(Latest) J:207152 Tomiyama K, et al., Phenotypic characterization of orofacial movement topography in mutants with disruption of amino acid mechanisms: glutamate N2A/B/D [GluRepsilon1/2/4] subtypes and the GABA synthesizing enzyme GAD65. Neuroscience. 2013 Oct 10;250:743-54
All references(70)
Other
accession IDs
MGD-MRK-10261

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory