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Grin2d Gene Detail
Summary
  • Symbol
    Grin2d
  • Name
    glutamate receptor, ionotropic, NMDA2D (epsilon 4)
  • Synonyms
    GluN2D, GluRepsilon4, NMDAR2D, NR2D
  • Feature Type
    protein coding gene
  • IDs
    MGI:95823
    NCBI Gene: 14814
  • Gene Overview
    MyGene.info: GRIN2D
Location & Maps
more
  • Sequence Map
    Chr7:45832483-45866681 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34199 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.54 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    GRIN2D, glutamate ionotropic receptor NMDA type subunit 2D
  • Vertebrate Orthologs
    6
  • Human Ortholog
    GRIN2D, glutamate ionotropic receptor NMDA type subunit 2D
    Orthology source: HomoloGene
  • Synonyms
    EB11, GluN2D, NMDAR2D, NR2D
  • Links
    NCBI Gene ID: 2906
    neXtProt AC: NX_O15399

  • Chr Location
    19q13.33; chr19:48394875-48444937 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Gene trapped
    1
  • Targeted
    2
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit reduced spontaneous activity and an elevated auditory brainstem response threshold.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002771 Ensembl Gene Model | MGI Sequence Detail 34199 C57BL/6J ±  kb
transcript ENSMUST00000002848 Ensembl | MGI Sequence Detail 4383 Not Applicable  
polypeptide ENSMUSP00000002848 Ensembl | MGI Sequence Detail 1323 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    385 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008249 glutamate receptor ionotropic, NMDA 2D
  • InterPro Domains
    IPR001320 Ionotropic glutamate receptor
    IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
    IPR001508 Ionotropic glutamate receptor, metazoa
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
Molecular
Reagents
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  • All nucleic 26
    Genomic 4
    cDNA 20
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10261
References
more
  • Summaries
    All 68
    Developmental Gene Expression 9
    Gene Ontology 11
    Phenotypes 24
  • Earliest
    J:3203 Ikeda K, et al., Cloning and expression of the epsilon 4 subunit of the NMDA receptor channel. FEBS Lett. 1992 Nov 16;313(1):34-8
  • Latest
    J:228753 Yamamoto T, et al., Role of the NMDA receptor GluN2D subunit in the expression of ketamine-induced behavioral sensitization and region-specific activation of neuronal nitric oxide synthase. Neurosci Lett. 2016 Jan 1;610:48-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory