Grin1
Gene Detail

Symbol Name ID

Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) MGI:95819

Synonyms

GluRzeta1, M100174, Nmdar, NMDAR1, NR1, Rgsc174

Feature Type

protein coding gene

Genetic Map

Chromosome 2

17.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr2:25291181-25319187 bp, - strand From VEGA annotation of GRCm38   28007 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7187  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: ionotropic glutamate receptor, AMPA/kainate types
Gene Tree: Grin1

Human homologs

Human Homolog		GRIN1, glutamate receptor, ionotropic, N-methyl D-aspartate 1
NCBI Gene ID		2902
neXtProt AC		NX_Q05586
Human Synonyms		GluN1, MRD8, NMDA1, NMDAR1, NR1
Human Chr (Location)		9q34.3; chr9:140033609-140063214 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GRIN1

Alleles and phenotypes

All alleles(30) : Targeted(27) Gene trapped(2) Chemically induced(1)
 

Null mutants lack whisker patterns in brain cortex, are ataxic and die neonatally of respiratory failure. Hypomorph mutants exhibit hyperactivity, stereotypy, and impaired social/sexual interactions. Mice homozygous for an ENU-induced allele exhibit abnormal behavior and neuron physiology.

 
Human Diseases Modeled Using Mouse Grin1 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (166 annotations)

Process	adult locomotory behavior, associative learning, ...
Component	cell junction, cell surface, ...
Function	calcium channel activity, calcium ion binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (43 records)
Data Summary: Results (386)    Tissues (179)    Images (52)
Theiler Stages: 19, 21, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	325
Western blot	1
RT-PCR	54
RNase protection	4

cDNA source data(54)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(61) cDNA(55) Primer pair(4) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000011933 (Evidence)
Ensembl Gene Model	ENSMUSG00000026959 (Evidence)
Entrez Gene	14810 (Evidence)
UniGene	278672
DFCI	TC1581108, TC1592092, TC1606774, TC1714670
DoTS	DT.101370911, DT.101706476, DT.103564086, DT.110661887, DT.40185719, DT.91421038
Consensus CDS Project	CCDS15764.1, CCDS50528.1, CCDS50529.1
International Mouse Knockout Project Status	Grin1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011933	VEGA Gene Model | MGI Sequence Detail	28007	C57BL/6J
transcript	OTTMUST00000028189	VEGA | MGI Sequence Detail	4276	Not Applicable
polypeptide	OTTMUSP00000012763	VEGA | MGI Sequence Detail	959	Not Applicable

All sequences(81) RefSeq(6) UniProt(8)

Polymorphisms

RFLP(4) : SNPs(54 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018882	Calmodulin-binding domain C0, NMDA receptor, NR1 subunit
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR001638	Extracellular solute-binding protein, family 3
InterPro	IPR019594	Glutamate receptor, L-glutamate/glycine-binding
InterPro	IPR001320	Ionotropic glutamate receptor
InterPro	IPR001508	NMDA receptor
Protein Ontology	PR:000008245	glutamate [NMDA] receptor subunit zeta-1

References

(Earliest) J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
(Latest) J:192654 Huang CC, et al., Activation of NMDA receptors reduces metabotropic glutamate receptor-induced long-term depression in the nucleus accumbens via a CaMKII-dependent mechanism. Neuropharmacology. 2012 Dec;63(8):1298-307
All references(262)

Other accession IDs

MGD-MRK-10257, MGD-MRK-12899, MGI:3798976