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Grin1 Gene Detail
Summary
  • Symbol
    Grin1
  • Name
    glutamate receptor, ionotropic, NMDA1 (zeta 1)
  • Synonyms
    GluRzeta1, M100174, Nmdar, NMDAR1, NR1, Rgsc174
  • Feature Type
    protein coding gene
  • IDs
    MGI:95819
    NCBI Gene: 14810
  • Gene Overview
    MyGene.info: GRIN1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr2:25291181-25319187 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      28007 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 17.14 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    GRIN1, glutamate ionotropic receptor NMDA type subunit 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRIN1, glutamate ionotropic receptor NMDA type subunit 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GluN1, MRD8, NDHMSD, NDHMSR, NMDA1, NMDAR1, NMD-R1, NR1
  • Links
    NCBI Gene ID: 2902
    neXtProt AC: NX_Q05586
    UniProt: Q05586

  • Chr Location
    9q34.3; chr9:137139092-137168762 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Grin1 mouse models; 1 with human GRIN1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    111 phenotypes from 24 alleles in 27 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    184 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Null mutants lack whisker patterns in brain cortex, are ataxic and die neonatally of respiratory failure. Hypomorph mutants exhibit hyperactivity, stereotypy, and impaired social/sexual interactions. Mice homozygous for an ENU-induced allele exhibit abnormal behavior and neuron physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    188
  • GO References
    91
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    418
  • Tissues
    193
  • cDNA Data
    54
  • Literature Summary
    55
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000011933 VEGA Gene Model | MGI Sequence Detail 28007 C57BL/6J ±  kb
    transcript OTTMUST00000028189 VEGA | MGI Sequence Detail 4276 Not Applicable  
    polypeptide OTTMUSP00000012763 VEGA | MGI Sequence Detail 959 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      63 from dbSNP Build 142
    • RFLP
      4
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000008245 glutamate receptor ionotropic, NMDA 1
      (term hierarchy)
    • InterPro Domains
      IPR018882 Calmodulin-binding domain C0, NMDA receptor, NR1 subunit
      IPR001320 Ionotropic glutamate receptor
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 55
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10257, MGD-MRK-12899, MGI:3798976
    References
    more
    • Summaries
      All 394
      Developmental Gene Expression 55
      Diseases 2
      Gene Ontology 91
      Phenotypes 184
    • Earliest
      J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
    • Latest
      J:263910 Geddes CE, et al., Optogenetic Editing Reveals the Hierarchical Organization of Learned Action Sequences. Cell. 2018 Jun 28;174(1):32-43.e15
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/09/2018
    MGI 6.12     		The Jackson Laboratory