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Grin1
Gene Detail
 Symbol
Name
ID
Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
MGI:95819
Synonyms GluRzeta1, M100174, Nmdar, NMDAR1, NR1, Rgsc174
Feature Type protein coding gene
Genetic Map
Chromosome 2
17.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr2:25291181-25319187 bp, - strand
From VEGA annotation of GRCm38

  28007 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7187  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: ionotropic glutamate receptor, AMPA/kainate types
Gene Tree: Grin1

Human
homologs
Human Homolog GRIN1, glutamate receptor, ionotropic, N-methyl D-aspartate 1
NCBI Gene ID 2902
neXtProt AC  NX_Q05586
Human Synonyms  GluN1, MRD8, NMDA1, NMDAR1, NR1
Human Chr (Location)  9q34.3; chr9:137139157-137168762 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GRIN1
Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Chemically induced (ENU)(1) Gene trapped(2) Targeted(28)
Incidental mutations (data from Mutagenetix , APF )
 
Null mutants lack whisker patterns in brain cortex, are ataxic and die neonatally of respiratory failure. Hypomorph mutants exhibit hyperactivity, stereotypy, and impaired social/sexual interactions. Mice homozygous for an ENU-induced allele exhibit abnormal behavior and neuron physiology.
 
Human Diseases Modeled Using Mouse Grin1 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)
Interactions
Grin1 interacts with 194 markers (Mir7b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (163 annotations)
Process adult locomotory behavior, associative learning, ...
Component cell, cell junction, ...
Function calcium channel activity, calcium ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (45 records)
Data Summary: Results (386)    Tissues (181)    Images (52)
Theiler Stages: 19, 21, 22, 23, 26, 27, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 325
Western blot 1
RT-PCR 54
RNase protection 4
cDNA source data(53)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(60) cDNA(54) Primer pair(4) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000011933 (Evidence)
Ensembl Gene ModelENSMUSG00000026959 (Evidence)
Entrez Gene14810 (Evidence)
UniGene278672
DFCITC1581108, TC1592092, TC1606774, TC1714670
DoTSDT.101370911, DT.101370912, DT.101706476, DT.103564086, DT.110661887, DT.40185719, DT.91421038
Consensus CDS ProjectCCDS15764.1, CCDS50528.1, CCDS50529.1
International Mouse Knockout Project StatusGrin1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011933 VEGA Gene Model | MGI Sequence Detail 28007 C57BL/6J ±  kb
transcript OTTMUST00000028189 VEGA | MGI Sequence Detail 4276 Not Applicable 
polypeptide OTTMUSP00000012763 VEGA | MGI Sequence Detail 959 Not Applicable 

For the selected sequences
All sequences(94) RefSeq(16) UniProt(8)
Polymorphisms RFLP(4) : SNPs within 2kb(63 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018882 Calmodulin-binding domain C0, NMDA receptor, NR1 subunit
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR001638 Extracellular solute-binding protein, family 3
InterPro IPR019594 Glutamate receptor, L-glutamate/glycine-binding
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR001508 NMDA receptor
Protein Ontology PR:000008245 glutamate receptor ionotropic, NMDA 1
References (Earliest) J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
(Latest) J:212197 Pozzi L, et al., Mice lacking NMDA receptors in parvalbumin neurons display normal depression-related behavior and response to antidepressant action of NMDAR antagonists. PLoS One. 2014;9(1):e83879
All references(291)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-10257, MGD-MRK-12899, MGI:3798976

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory