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Grin1
Gene Detail
Symbol

Name
ID
Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
MGI:95819
Synonyms
GluRzeta1, M100174, Nmdar, NMDAR1, NR1, Rgsc174
Feature Type
protein coding gene
Genetic Map
Chromosome 2
17.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr2:25291181-25319187 bp, - strand
From VEGA annotation of GRCm38

  28007 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7187  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: GRIN1
Protein SuperFamily: ionotropic glutamate receptor, AMPA/kainate types
Gene Tree: Grin1

Human
homologs
GRIN1, glutamate receptor, ionotropic, N-methyl D-aspartate 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2902
neXtProt AC: NX_Q05586

Human Synonyms: GluN1, MRD8, NMDA1, NMDAR1, NMD-R1, NR1

Human Chr (Location): 9q34.3; chr9:137139112-137168762 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GRIN1

Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Chemically induced (ENU)(1) Gene trapped(2) Targeted(28)
Incidental mutations (data from Mutagenetix , APF )
 
Null mutants lack whisker patterns in brain cortex, are ataxic and die neonatally of respiratory failure. Hypomorph mutants exhibit hyperactivity, stereotypy, and impaired social/sexual interactions. Mice homozygous for an ENU-induced allele exhibit abnormal behavior and neuron physiology.
 
Human Diseases Modeled in Mice Using Grin1 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(1)
Interactions
Grin1 interacts with 194 markers (Mir7b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (162 annotations)
Process adult locomotory behavior, associative learning, ...
Component cell, cell junction, ...
Function calcium channel activity, calcium ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (46 records)
Data Summary: Results (386)    Tissues (181)    Images (52)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 325
Western blot 1
RT-PCR 54
RNase protection 4
cDNA source data(53)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA GRIN1 ; Xenbase grin1 ; ZFIN grin1b    NEW 
Molecular
reagents
All nucleic(60) cDNA(54) Primer pair(4) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000011933 (Evidence)
Ensembl Gene Model ENSMUSG00000026959 (Evidence)
Entrez Gene 14810 (Evidence)
UniGene 278672
DFCI TC1581108, TC1592092, TC1606774, TC1714670
DoTS DT.101370911, DT.101370912, DT.101706476, DT.103564086, DT.110661887, DT.40185719, DT.91421038
Consensus CDS Project CCDS15764.1, CCDS50528.1, CCDS50529.1
International Mouse Phenotyping Consortium Status Grin1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011933 VEGA Gene Model | MGI Sequence Detail 28007 C57BL/6J ±  kb
transcript OTTMUST00000028189 VEGA | MGI Sequence Detail 4276 Not Applicable 
polypeptide OTTMUSP00000012763 VEGA | MGI Sequence Detail 959 Not Applicable 

For the selected sequences
All sequences(94) RefSeq(16) UniProt(8)
Polymorphisms
RFLP(4) : SNPs within 2kb(63 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018882 Calmodulin-binding domain C0, NMDA receptor, NR1 subunit
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR019594 Glutamate receptor, L-glutamate/glycine-binding
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR001508 NMDA receptor
Protein Ontology PR:000008245 glutamate receptor ionotropic, NMDA 1
References
(Earliest) J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
(Latest) J:221454 Darvas M, et al., Specific contributions of N-methyl-D-aspartate receptors in the dorsal striatum to cognitive flexibility. Neuroscience. 2015 Jan 22;284:934-42
All references(296)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-10257, MGD-MRK-12899, MGI:3798976

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory