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Grin1 Gene Detail
Summary
  • Symbol
    Grin1
  • Name
    glutamate receptor, ionotropic, NMDA1 (zeta 1)
  • Synonyms
    GluRzeta1, M100174, Nmdar, NMDAR1, NR1, Rgsc174
  • Feature Type
    protein coding gene
  • IDs
    MGI:95819
    NCBI Gene: 14810
  • Gene Overview
    MyGene.info: GRIN1
Location & Maps
more
  • Sequence Map
    Chr2:25291181-25319187 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      28007 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 17.14 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    GRIN1, glutamate ionotropic receptor NMDA type subunit 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRIN1, glutamate ionotropic receptor NMDA type subunit 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GluN1, MRD8, NMDA1, NMDAR1, NMD-R1, NR1
  • Links
    NCBI Gene ID: 2902
    neXtProt AC: NX_Q05586
    UniProt: Q05586

  • Chr Location
    9q34.3; chr9:137139092-137168762 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Grin1 mouse models; 1 with human GRIN1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    111 phenotypes from 24 alleles in 27 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    159 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null mutants lack whisker patterns in brain cortex, are ataxic and die neonatally of respiratory failure. Hypomorph mutants exhibit hyperactivity, stereotypy, and impaired social/sexual interactions. Mice homozygous for an ENU-induced allele exhibit abnormal behavior and neuron physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    161
  • GO References
    86
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    409
  • Tissues
    190
  • cDNA Data
    53
  • Literature Summary
    49
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011933 VEGA Gene Model | MGI Sequence Detail 28007 C57BL/6J ±  kb
transcript OTTMUST00000028189 VEGA | MGI Sequence Detail 4276 Not Applicable  
polypeptide OTTMUSP00000012763 VEGA | MGI Sequence Detail 959 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    63 from dbSNP Build 142
  • RFLP
    4
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000008245 glutamate receptor ionotropic, NMDA 1
    (term hierarchy)
  • InterPro Domains
    IPR018882 Calmodulin-binding domain C0, NMDA receptor, NR1 subunit
    IPR001320 Ionotropic glutamate receptor
    IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
    IPR001508 Ionotropic glutamate receptor, metazoa
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
Molecular
Reagents
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  • All nucleic 59
    cDNA 54
    Primer pair 4
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10257, MGD-MRK-12899, MGI:3798976
References
more
  • Summaries
    All 323
    Developmental Gene Expression 49
    Diseases 2
    Gene Ontology 86
    Phenotypes 159
  • Earliest
    J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
  • Latest
    J:240678 Liu S, et al., A Rare Variant Identified Within the GluN2B C-Terminus in a Patient with Autism Affects NMDA Receptor Surface Expression and Spine Density. J Neurosci. 2017 Apr 12;37(15):4093-4102
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/13/2017
MGI 6.10 		The Jackson Laboratory