Grin1
Gene Detail

Symbol

Name
ID

Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
MGI:95819

Synonyms

GluRzeta1, M100174, Nmdar, NMDAR1, NR1, Rgsc174

Feature Type

protein coding gene

Genetic Map

Chromosome 2
17.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr2:25291181-25319187 bp, - strand From VEGA annotation of GRCm38   28007 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:7187  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: ionotropic glutamate receptor, AMPA/kainate types
Gene Tree: Grin1

Human
homologs

Human Homolog		GRIN1, glutamate receptor, ionotropic, N-methyl D-aspartate 1
NCBI Gene ID		2902
neXtProt AC		NX_Q05586
Human Synonyms		GluN1, MRD8, NMDA1, NMDAR1, NMD-R1, NR1
Human Chr (Location)		9q34.3; chr9:137139157-137168762 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human GRIN1

Mutations,
alleles, and
phenotypes

All mutations/alleles(31) : Chemically induced (ENU)(1) Gene trapped(2) Targeted(28)
Incidental mutations (data from Mutagenetix , APF )
 

Null mutants lack whisker patterns in brain cortex, are ataxic and die neonatally of respiratory failure. Hypomorph mutants exhibit hyperactivity, stereotypy, and impaired social/sexual interactions. Mice homozygous for an ENU-induced allele exhibit abnormal behavior and neuron physiology.

 
Human Diseases Modeled in Mice Using Grin1 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(1)

Interactions

Grin1 interacts with 194 markers (Mir7b, Mir15a, Mir15b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (161 annotations)

Process	adult locomotory behavior, associative learning, ...
Component	cell, cell junction, ...
Function	calcium channel activity, calcium ion binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (46 records)

Data Summary: Results (386)    Tissues (181)    Images (52)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	2
RNA in situ	325
Western blot	1
RT-PCR	54
RNase protection	4

cDNA source data(53)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(60) cDNA(54) Primer pair(4) Other(2)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000011933 (Evidence)
Ensembl Gene Model	ENSMUSG00000026959 (Evidence)
Entrez Gene	14810 (Evidence)
UniGene	278672
DFCI	TC1581108, TC1592092, TC1606774, TC1714670
DoTS	DT.101370911, DT.101370912, DT.101706476, DT.103564086, DT.110661887, DT.40185719, DT.91421038
Consensus CDS Project	CCDS15764.1, CCDS50528.1, CCDS50529.1
International Mouse Knockout Project Status	Grin1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011933	VEGA Gene Model | MGI Sequence Detail	28007	C57BL/6J
transcript	OTTMUST00000028189	VEGA | MGI Sequence Detail	4276	Not Applicable
polypeptide	OTTMUSP00000012763	VEGA | MGI Sequence Detail	959	Not Applicable

All sequences(94) RefSeq(16) UniProt(8)

Polymorphisms

RFLP(4) : SNPs within 2kb(63 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR018882	Calmodulin-binding domain C0, NMDA receptor, NR1 subunit
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR019594	Glutamate receptor, L-glutamate/glycine-binding
InterPro	IPR001320	Ionotropic glutamate receptor
InterPro	IPR001508	NMDA receptor
Protein Ontology	PR:000008245	glutamate receptor ionotropic, NMDA 1

References

(Earliest) J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
(Latest) J:216294 Kumar A, et al., Analysis of Presenilin 1 and 2 interacting proteins in mouse cerebral cortex during development. Int J Dev Neurosci. 2014 Nov;38:138-46
All references(294)
Disease annotation references (2)

Other
accession IDs

MGD-MRK-10257, MGD-MRK-12899, MGI:3798976