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Symbol
Name
ID 		Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
MGI:95819
Phenotype annotations related to behavior/neurological
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Feeding difficulties
Inappropriate laughter
Bruxism
Stereotypical hand wringing
Self-injurious behavior
Disease(s) Associated with GRIN1
autosomal dominant intellectual developmental disorder 8
developmental and epileptic encephalopathy 101

Mouse Phenotypes
behavior/neurological phenotype
abnormal behavioral response to xenobiotic
decreased alcohol consumption
increased alcohol consumption
abnormal behavioral response to addictive substance
abnormal behavioral response to alcohol
impaired behavioral response to cocaine
decreased susceptibility to pharmacologically induced seizures
increased susceptibility to pharmacologically induced seizures
abnormal conditioned taste aversion behavior
impaired passive avoidance behavior
impaired conditioned place preference behavior
abnormal contextual conditioning behavior
abnormal discrimination learning
abnormal olfactory discrimination memory
impaired social transmission of food preference
abnormal motor learning
abnormal object recognition memory
increased exploration in new environment
abnormal spatial learning
abnormal spatial working memory
abnormal liquid preference
abnormal food intake
aphagia
absent gastric milk in neonates
abnormal suckling behavior
absent suckling reflex
decreased aggression towards mice
abnormal anxiety-related response
increased anxiety-related response
increased thigmotaxis
increased grooming behavior
abnormal motor capabilities/coordination/movement
abnormal postural reflex
impaired righting response
increased startle reflex
limb grasping
ataxia
impaired coordination
abnormal locomotor behavior
decreased vertical activity
decreased locomotor activity
increased locomotor activity
hyperactivity
stereotypic behavior
abnormal social/conspecific interaction behavior
abnormal huddling behavior
abnormal maternal nurturing
abnormal maternal grooming
absent maternal crouching
abnormal pup retrieval
pup cannibalization
abnormal nest building behavior
abnormal sexual interaction
reduced male mating frequency
abnormal social investigation
social withdrawal
decreased vocalization
tonic-clonic seizures
Availability Mouse Genotype
Grin1tm1.1Ese/Grin1tm1.1Ese
Grin1tm1.1Phs/Grin1tm1.1Phs
Grin1tm1Bhk/Grin1tm1Bhk
Grin1tm1Blt/Grin1tm1Blt
Grin1tm1Cur/Grin1tm1Cur
Grin1tm1Nak/Grin1tm1Nak
Grin1tm1Stl/Grin1tm1Stl
Grin1tm2Blt/Grin1tm2Blt
Grin1tm2Phs/Grin1tm2Phs
Grin1Rgsc174/Grin1+ *
Grin1tm1.1Phs/Grin1+
Grin1tm1.1Slab/Grin1+
Grin1tm1Cur/Grin1tm1.1Phs
Grin1tm1Cur/Grin1tm2.1Phs
Grin1tm1Jjwd/Grin1+
Grin1tm2.1Phs/Grin1+
Grik4tm1(cre)Mim/Grik4+
Grin1tm1Mim/Grin1tm1Mim  (conditional)
Grin1tm1Rsp/Grin1tm1Rsp
Tg(Camk2a-tTA)1Mmay/?
Tg(tetO-cre)LC1Bjd/?  (conditional)
Grin1tm1Rsp/Grin1tm1Rsp
Tg(Slc6a3-icre)9075Gsc/0  (conditional)
Grin1tm1Yql/Grin1tm1Yql
Rgs9tm1.1(cre)Yql/Rgs9+  (conditional)
Grin1tm1Yql/Grin1tm1Yql
Tg(Ppp1r2-cre)4127Nkza/0  (conditional)		 *
Grin1tm2Stl/Grin1tm2Stl
Tg(Camk2a-cre)T29-1Stl/0  (conditional)
Grin1tm2Stl/Grin1tm2Stl
Tg(Grik4-cre)G32-4Stl/0  (conditional)
Grin1tm2Stl/Grin1tm2Stl
Tg(Pomc-cre)1Lowl/0  (conditional)		 *
Grin1tm2Stl/Grin1tm2Stl
Tg(Ppp1r2-cre)4127Nkza/0  (conditional)		 *
Grin1tm1Rpa/Grin1tm1.1Rpa
Slc6a3tm1(cre)Xz/Slc6a3+  (conditional)
Grin1tm1Rpa/Grin1tm1.1Rpa  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory