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Gene Detail
low density lipoprotein receptor-related protein 2
Synonyms b2b1625.2Clo, D230004K18Rik, Gp330, Megalin
Feature Type protein coding gene
Genetic Map
Chromosome 2
40.74 cM
Detailed Genetic Map ± 1 cM

Mapping data(11)
Sequence Map
Chr2:69424340-69586065 bp, - strand
From VEGA annotation of GRCm38

  161726 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:20952  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: LDL receptor-related protein
Gene Tree: Lrp2

Human Homolog LRP2, low density lipoprotein receptor-related protein 2
NCBI Gene ID 4036
neXtProt AC  NX_P98164
Human Synonyms  DBS, GP330
Human Chr (Location)  2q31.1; chr2:169127109-169362613 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human LRP2
alleles, and
All mutations/alleles(30) : Chemically induced (ENU)(4) Gene trapped(21) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
Homozygotes for a targeted null mutation exhibit lung and kidney epithelial defects, impaired B12 uptake, reduced proliferation of the neuroepithelium resulting in lack of olfactory bulbs, forebrain fusions, ventricular defects, and perinatal lethality.
Human Diseases Modeled Using Mouse Lrp2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(29)
Lrp2 interacts with 347 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
All GO classifications: (48 annotations)
Process cell proliferation, endocytosis, ...
Component apical part of cell, apical plasma membrane, ...
Function calcium ion binding, hemoglobin binding, ...
External Resources: FuncBase
Literature Summary: (32 records)
Data Summary: Results (259)    Tissues (130)    Images (30)
Theiler Stages: 8, 9, 10, 15, 19, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 46
RNA in situ 197
cDNA source data(127)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(132) cDNA(129) Primer pair(3)
Microarray probesets(5)
Other database
VEGA Gene ModelOTTMUSG00000012988 (Evidence)
Ensembl Gene ModelENSMUSG00000027070 (Evidence)
Entrez Gene14725 (Evidence)
DFCITC1608935, TC1655996, TC1677693, TC1703921
DoTSDT.530178, DT.91349072, DT.94166164, DT.97389734
NIA Mouse Gene IndexU022710
Consensus CDS ProjectCCDS38135.1
International Mouse Knockout Project StatusLrp2
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012988 VEGA Gene Model | MGI Sequence Detail 161726 C57BL/6J ±  kb
transcript OTTMUST00000031293 VEGA | MGI Sequence Detail 15460 Not Applicable 
polypeptide OTTMUSP00000014001 VEGA | MGI Sequence Detail 4660 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(3) UniProt(3)
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(1624 from dbSNP Build 137)
InterPro IPR026823 Complement Clr-like EGF domain
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000033 LDLR class B repeat
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000009921 low-density lipoprotein receptor-related protein 2
References (Earliest) J:14575 Xia YR, et al., Mapping of the glycoprotein 330 (Gp330) gene to mouse chromosome 2. Genomics. 1993 Sep;17(3):780-1
(Latest) J:203560 Burk RF, et al., Maternal-fetal transfer of selenium in the mouse. FASEB J. 2013 Aug;27(8):3249-56
All references(124)
Disease annotation references (1)
accession IDs
MGD-MRK-10218, MGI:2138891, MGI:2139361, MGI:2444234, MGI:5489921

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory