114 phenotypes from 6 alleles in 13 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Foxg1tm1(cre)Skm/Foxg1+ Lrp2tm1Tew/Lrp2tm1Tew involves: 129P2/OlaHsd	abnormal dendrite morphology	J:238249
	abnormal eye morphology	J:238249
	abnormal intraocular pressure	J:238249
	abnormal lens morphology	J:238249
	abnormal optic nerve morphology	J:238249
	abnormal placement of pupils	J:238249
	abnormal posterior eye segment morphology	J:238249
	abnormal retina bipolar cell morphology	J:238249
	abnormal retina pigment epithelium morphology	J:238249
	abnormal retina pigmentation	J:238249
	abnormal sclera morphology	J:238249
	absent corpus callosum	J:238249
	decreased cell proliferation	J:238249
	decreased retina ganglion cell number	J:238249
	decreased total retina thickness	J:238249
	high myopia	J:238249
	increased retina apoptosis	J:238249
	macrophthalmia	J:238249
	ocular hypotelorism	J:238249
	sclera thinning	J:238249
	thin retina inner nuclear layer	J:238249
	thin retina inner plexiform layer	J:238249
	thin retina outer nuclear layer	J:238249
H2az2Tg(Wnt1-cre)11Rth/H2az2+ Lrp2tm1Tew/Lrp2tm1Tew involves: C57BL/6J * CBA/J	normal vision/eye phenotype	J:238249
Lrp227SH/Lrp227SH involves: A/J * C57BL/6N	abnormal brain morphology	J:186668
	abnormal cerebellum fissure morphology	J:186668
	abnormal eye morphology	J:186668
	abnormal forebrain morphology	J:186668
	abnormal lateral ventricle morphology	J:186668
	abnormal olfactory bulb morphology	J:186668
	absent nasal septum	J:186668
	anophthalmia	J:186668
	cleft palate	J:186668
	holoprosencephaly	J:186668
	round forehead	J:186668
	small olfactory bulb	J:186668
Lrp2b2b1625.2Clo/Lrp2b2b1625.2Clo C57BL/6J-Lrp2b2b1625.2Clo	omphalocele	J:175213
	persistent truncus arteriosus type i	J:175213
	vascular ring	J:175213
Lrp2b2b2671Clo/Lrp2b2b2671Clo C57BL/6J-Lrp2b2b2671Clo	abnormal aortic arch morphology	J:175213
	abnormal myocardium compact layer morphology	J:175213
	anophthalmia	J:175213
	heart left ventricle hypertrophy	J:175213
	heart right ventricle hypertrophy	J:175213
	hydronephrosis	J:175213
	kidney cyst	J:175213
	kinked tail	J:175213
	micrognathia	J:175213
	microphthalmia	J:175213
	muscular ventricular septal defect	J:175213
	perimembraneous ventricular septal defect	J:175213
	persistent truncus arteriosus	J:175213
	right aortic arch	J:175213
	short snout	J:175213
	thymus hypoplasia	J:175213
	umbilical hernia	J:175213
	ventricular septal defect	J:175213
Lrp2m267Asp/Lrp2m267Asp involves: C57BL/6J * FVB/N	abnormal circulating mineral level	J:166387
	abnormal selenium level	J:166387
	decreased glutathione peroxidase activity	J:166387
	exencephaly	J:166387
	impaired coordination	J:166387
	increased urine protein level	J:166387
	increased urine selenium level	J:166387
Lrp2m267Asp/Lrp2m267Asp Tg(Rr291-lacZ)#Mekk/0 involves: C57BL/6J * FVB/N	abnormal cerebral cortex morphology	J:136795
	abnormal diencephalon morphology	J:136795
	abnormal olfactory bulb morphology	J:136795
	choroid plexus hyperplasia	J:136795
Lrp2tm1Her/Lrp2+ involves: 129S7/SvEvBrd * C57BL/6	abnormal ear physiology	J:134797
	impaired hearing	J:134797
	increased or absent threshold for auditory brainstem response	J:134797
Lrp2tm1Her/Lrp2tm1Her either: (involves: 129S7/SvEvBrd * CD-1) or (involves: 129/SvEmcTer * 129S7/SvEvBrd * C57BL/6N)	abnormal response/metabolism to endogenous compounds	J:115189
	abnormal testis development	J:115189
	abnormal testis morphology	J:115189
	dilated uterus	J:115189
	increased circulating dihydrotestosterone level	J:115189
	increased circulating testosterone level	J:115189
	unilateral cryptorchism	J:115189
	vaginal septum	J:115189
Lrp2tm1Her/Lrp2tm1Her involves: 129S7/SvEvBrd	abnormal choroid plexus morphology	J:34835
	abnormal embryonic neuroepithelium morphology	J:34835
	abnormal forebrain development	J:34835
	abnormal proximal convoluted tubule morphology	J:34835, J:108230
	abnormal respiratory system physiology	J:34835
	abnormal telencephalon morphology	J:34835
	abnormal urine homeostasis	J:108230
	abnormal viscerocranium morphology	J:34835
	absent corpus callosum	J:34835
	absent olfactory bulb	J:34835
	anophthalmia	J:34835
	atelectasis	J:34835
	cyanosis	J:34835
	decreased embryo size	J:34835
	delayed neural tube closure	J:34835
	emphysema	J:34835
	exencephaly	J:34835
	flat forehead	J:34835
	holoprosencephaly	J:34835
	increased apoptosis	J:34835
	increased urine microglobulin level	J:108230
	increased urine protein level	J:108230, J:184259
	microphthalmia	J:34835
	overexpanded pulmonary alveolus	J:34835
	perinatal lethality, complete penetrance	J:34835
	respiratory failure	J:34835
	short snout	J:34835
	small embryonic telencephalon	J:34835
Lrp2tm1Her/Lrp2tm1Her involves: 129S7/SvEvBrd * C57BL/6	abnormal hearing physiology	J:134797
	abnormal strial marginal cell morphology	J:134797
	impaired hearing	J:134797
	increased or absent threshold for auditory brainstem response	J:134797
	increased susceptibility to age-related hearing loss	J:134797
	perinatal lethality, incomplete penetrance	J:134797
Lrp2tm1Her/Lrp2tm1Her involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ	abnormal selenium level	J:211934
	normal behavior/neurological phenotype	J:211934
	decreased glutathione peroxidase activity	J:211934
	normal growth/size/body region phenotype	J:211934
	increased urine selenium level	J:211934
Lrp2tm1Tew/Lrp2tm1Tew Not Specified	decreased bone mineral content	J:81496
	normal homeostasis/metabolism phenotype	J:81496
	normal nervous system phenotype	J:81496
Lrp2tm1Tew/Lrp2tm1Tew Meox2tm1(cre)Sor/Meox2+ involves: 129S4/SvJaeSor	abnormal renal reabsorption	J:164025
Lrp2tm1Tew/Lrp2tm1Tew Tg(APOE-cre)VITew/0 Not Specified	abnormal bone mineralization	J:81496
	abnormal bone remodeling	J:81496
	abnormal urine homeostasis	J:81496
	abnormal vitamin D level	J:81496
	decreased bone mineral content	J:81496
	decreased circulating calcium level	J:81496
	increased bone resorption	J:81496
	increased circulating parathyroid hormone level	J:81496
	increased urine protein level	J:81496
	osteomalacia	J:81496
Lrp2tm1Tew/Lrp2tm1Tew Tg(GFAP-cre)25Mes/0 involves: FVB/N	normal vision/eye phenotype	J:238249