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Phenotypes Associated with This Genotype
Genotype
MGI:4847969
Allelic
Composition
Lrp2m267Asp/Lrp2m267Asp
Genetic
Background
involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp2m267Asp mutation (0 available); any Lrp2 mutation (260 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• performance on the rotarod task is indistinguishable from controls when fed a selenium-adequate diet, however when mutants are fed a low-selenium diet for 4 weeks after weaning, mice exhibit impaired movement coordination on the rotarod

homeostasis/metabolism
• serum selenium levels are reduced irrespective of the food selenium content
• levels of serum selenoprotein P are reduced
• urinary selenium content is increased while serum selenium levels are reduced
• with adequate dietary selenium intake, renal selenium content is not significantly changed in mutants, however upon dietary selenium restriction, renal selenium content is significantly reduced in mutants
• selenium levels in liver and brain are reduced
• selenoprotein P (SePP) is present in urine of mutants but not wild-type mice
• urinary selenium content is increased
• activity of the selenoenzyme glutathione peroxidase (GPx) is reduced in the plasma, in the brain, kidney, and liver

nervous system
• mild exencephaly

renal/urinary system
• selenoprotein P (SePP) is present in urine of mutants but not wild-type mice
• urinary selenium content is increased

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Donnai-Barrow syndrome DOID:0090144 OMIM:222448
J:166387


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory