Phenotypes for Foxg1 Lrp2 MGI:6199478 MGI Mouse

increased retina apoptosis ( J:238249 )

• increase in cell death in the retina between P5 and P21 and cell death increases, especially in the ganglion cell layer, with age

abnormal eye morphology ( J:238249 )

• the retrobulbar space (the space between the eyeball and the orbit) is reduced

• excessive axial elongation and posterior pole degenerative changes in eyes

• chorioretinal atrophy in some cases

• myopic chorioretinopathy

abnormal placement of pupils ( J:238249 )

• anterior segment is generally normal although pupillary ectopia is occasionally seen

abnormal lens morphology ( J:238249 )

• the lens thickness increases during postnatal development as in wild-type eyes but is lower at P330 and P390

ocular hypotelorism ( J:238249 )

• shorter inter-ocular distance

macrophthalmia ( J:238249 )

• bilateral eye enlargement

• eyes are 30% and 40% longer at P60 and P180

abnormal posterior eye segment morphology ( J:238249 )

• posterior staphyloma is seen from P21 onward

• lengthening of the ocular axis is primarily due to continuous vitreal chamber enlargement

• the vitreous chamber depth of eyes increases dramatically at all ages studied

• however, the anterior chamber depth and corneal radius of curvature increases similarly to wild-type from P15 to P510

decreased retina ganglion cell number ( J:238249 )

• cell density in the ganglion cell layer is first decreased at P15

abnormal retina bipolar cell morphology ( J:238249 )

• bipolar cells exhibit atrophic dendrites and their connections with the retinal ganglion cells appear thicker

abnormal optic nerve morphology ( J:238249 )

• reduction in the number of axons in the optic nerve at P150

• the optic nerve diameter is slightly increased at P150

abnormal retina pigment epithelium morphology ( J:238249 )

• peripapillary atrophy of the pigment epithelium consistent with a peripapillary staphyloma, a trait of myopic retinopathy

abnormal retina pigmentation ( J:238249 )

• widespread pigment dispersion affects most of the retina

thin retina inner nuclear layer ( J:238249 )

• thickness of the inner nuclear layer is decreased more than in wild-type mice from P5 to P90

• progressive decrease in cell density in the inner nuclear from P5 onwards

thin retina inner plexiform layer ( J:238249 )

• significant reduction of the inner plexiform layer thickness from P7 onwards

thin retina outer nuclear layer ( J:238249 )

• thickness of the outer nuclear layer is decreased more than in wild-type mice from P5 to P90

• progressive decrease in cell density in the outer nuclear layer from P5 onwards

decreased total retina thickness ( J:238249 )

• retinal thinning from P15 onwards

abnormal sclera morphology ( J:238249 )

• collagen fibrils in sclera form fewer lamellae at P90 and P180 and appear disorganized

• within lamellae, the organization of collagen fibrils is perturbed, with fibrils coursing parallel to each other and large areas devoid of fibrils rather than interweaving as in controls

• collagen fibril density is lower in the sclera

• morphology of collagen fibrils is very heterogeneous and their contour is irregular with rectangular- rather than oval-shaped fibrils, mean cross-sectional diameter is increased and the frequency of collagen fibers with both smaller and wider mean cross-sectional diameter is increased, indicating scleral staphyloma

sclera thinning ( J:238249 )

• scleral thickness at P90 and P180 is thinner by 33% and 50%, respectively

abnormal intraocular pressure ( J:238249 )

• intraocular pressure is lower at P330 and P390 but normal at other times

high myopia ( J:238249 )