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Gnaq Gene Detail
Summary
  • Symbol
    Gnaq
  • Name
    guanine nucleotide binding protein, alpha q polypeptide
  • Synonyms
    1110005L02Rik, 6230401I02Rik, Dsk1, Dsk10, Galphaq, G alpha q, Gq, GqI
  • Feature Type
    protein coding gene
  • IDs
    MGI:95776
    NCBI Gene: 14682
  • Gene Overview
    MyGene.info: GNAQ
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:16132831-16387453 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 11.01 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1653 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95776
protein coding gene Chr19:16132831-16387463 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024958
protein coding gene Chr19:13841129-14115382 (+)
A/J MGP_AJ_G0024935
protein coding gene Chr19:13047287-13304437 (+)
AKR/J MGP_AKRJ_G0024905
protein coding gene Chr19:13587304-13854709 (+)
BALB/cJ MGP_BALBcJ_G0024934
protein coding gene Chr19:13090705-13347423 (+)
C3H/HeJ MGP_C3HHeJ_G0024692
protein coding gene Chr19:13537105-13793735 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025376
protein coding gene Chr19:14405272-14681932 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022795
protein coding gene Chr19:13508644-13755692 (+)
CAST/EiJ MGP_CASTEiJ_G0024160
protein coding gene Chr19:13109622-13375900 (+)
CBA/J MGP_CBAJ_G0024670
protein coding gene Chr19:14840100-15124234 (+)
DBA/2J MGP_DBA2J_G0024802
protein coding gene Chr19:13088252-13345000 (+)
FVB/NJ MGP_FVBNJ_G0024763
protein coding gene Chr19:13017274-13267776 (+)
LP/J MGP_LPJ_G0024886
protein coding gene Chr19:13850236-14117642 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024790
protein coding gene Chr19:14803065-15061011 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025431
protein coding gene Chr19:13506795-13770812 (+)
PWK/PhJ MGP_PWKPhJ_G0023909
protein coding gene Chr19:12629235-12882051 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023714
protein coding gene Chr19:12802227-13073644 (+)
WSB/EiJ MGP_WSBEiJ_G0024228
protein coding gene Chr19:13529901-13793663 (+)



Homology
more
  • Human Ortholog
    GNAQ, G protein subunit alpha q
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GNAQ, G protein subunit alpha q
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMC1, G-ALPHA-q, GAQ, SWS
  • Links
    NCBI Gene ID: 2776
    neXtProt AC: NX_P50148
    UniProt: P50148

  • Chr Location
    9q21.2; chr9:77716274-78031449 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1566
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GNAQ
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Gnaq mouse models

Human Disease Mouse Models
      
IDs
View 2 models
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    68 phenotypes from 11 alleles in 10 genetic backgrounds
    123 phenotypes from multigenic genotypes
    1 images
    123 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutant mice exhibit pigmentation anomalies affecting the ears, tail and footpads.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14682 NCBI Gene Model | MGI Sequence Detail 254623 C57BL/6J ±  kb
    transcript NM_008139 RefSeq | MGI Sequence Detail 6848 C57BL/6  
    polypeptide P21279 UniProt | EBI | MGI Sequence Detail 359 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 18
      Primer pair 2
      Other 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-10188, MGI:1915032, MGI:1919038, MGI:2147433, MGI:2147701, MGI:2450681, MGI:2450695
    References
    more
    • Summaries
      All 209
      Developmental Gene Expression 13
      Diseases 5
      Gene Ontology 24
      Phenotypes 123
    • Earliest
      J:43412 Strathmann M, et al., G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates. Proc Natl Acad Sci U S A. 1990 Dec;87(23):9113-7
    • Latest
      J:269411 Harraz OF, et al., PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells. Elife. 2018 Aug 7;7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/11/2019
    MGI 6.14
    The Jackson Laboratory