About   Help   FAQ
Gnaq
Gene Detail
 Symbol
Name
ID
Gnaq
guanine nucleotide binding protein, alpha q polypeptide
MGI:95776
Synonyms 1110005L02Rik, 6230401I02Rik, Dsk1, Dsk10, Galphaq, G alpha q, Gq, GqI
Feature Type protein coding gene
Genetic Map
Chromosome 19
11.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr19:16132831-16387463 bp, + strand
From VEGA annotation of GRCm38

  254633 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1566  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gnaq

Human
homologs
Human Homolog GNAQ, guanine nucleotide binding protein (G protein), q polypeptide
NCBI Gene ID 2776
neXtProt AC  NX_P50148
Human Synonyms  CMC1, G-ALPHA-q, GAQ, SWS
Human Chr (Location)  9q21; chr9:77716274-78031449 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human GNAQ
Alleles
and
phenotypes
All alleles(9) : Chemically induced (ENU)(2) Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant mice exhibit pigmentation anomalies affecting the ears, tail and footpads.
 
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process action potential, activation of phospholipase C activity, ...
Component caveola, cytosol, ...
Function G-protein beta/gamma-subunit complex binding, G-protein coupled receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (56)    Tissues (44)    Images (12)
Theiler Stages: 1, 2, 3, 4, 15, 19, 20, 21, 23, 28
Assay TypeResults
RNA in situ 31
Western blot 13
RT-PCR 12
cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(20) cDNA(16) Primer pair(2) Other(2)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000036872 (Evidence)
Ensembl Gene ModelENSMUSG00000024639 (Evidence)
Entrez Gene14682 (Evidence)
DFCITC1578550, TC1598494, TC1639729, TC1707338
DoTSDT.101272903, DT.87068708, DT.94189421, DT.97358464
NIA Mouse Gene IndexU043709, U370108
PDB2BCJ, 2RGN, 3OHM, 4EKC, 4EKD, 4GNK, 3AH8
Consensus CDS ProjectCCDS29684.1
International Mouse Knockout Project StatusGnaq
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036872 VEGA Gene Model | MGI Sequence Detail 254633 C57BL/6J ±  kb
transcript OTTMUST00000094727 VEGA | MGI Sequence Detail 5644 Not Applicable 
polypeptide OTTMUSP00000052744 VEGA | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(1661 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000654 G-protein alpha subunit, group Q
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008090 guanine nucleotide-binding protein G(q) subunit alpha
References (Earliest) J:43412 Strathmann M, et al., G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates. Proc Natl Acad Sci U S A. 1990 Dec;87(23):9113-7
(Latest) J:206486 Rusu L, et al., G protein-dependent basal and evoked endothelial cell vWF secretion. Blood. 2014 Jan 16;123(3):442-50
All references(132)
Other
accession IDs
MGD-MRK-10188, MGI:1915032, MGI:1919038, MGI:2147433, MGI:2147701, MGI:2450681, MGI:2450695

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory