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Gnaq
Gene Detail
Symbol

Name
ID
Gnaq
guanine nucleotide binding protein, alpha q polypeptide
MGI:95776
Synonyms
1110005L02Rik, 6230401I02Rik, Dsk1, Dsk10, Galphaq, G alpha q, Gq, GqI
Feature Type
protein coding gene
Genetic Map
Chromosome 19
11.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr19:16132831-16387463 bp, + strand
From VEGA annotation of GRCm38

  254633 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1566  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GNAQ
Gene Tree: Gnaq

Human
homologs
GNAQ, guanine nucleotide binding protein (G protein), q polypeptide
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2776
neXtProt AC: NX_P50148

Human Synonyms: CMC1, G-ALPHA-q, GAQ, SWS

Human Chr (Location): 9q21; chr9:77716274-78031449 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human GNAQ

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(2) Gene trapped(2) Targeted(5) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutant mice exhibit pigmentation anomalies affecting the ears, tail and footpads.
 
Interactions
Gnaq interacts with 414 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process action potential, activation of phospholipase C activity, ...
Component caveola, cytosol, ...
Function G-protein beta/gamma-subunit complex binding, G-protein coupled receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (53)    Tissues (41)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 31
Western blot 13
RT-PCR 9
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gnaq    NEW 
Molecular
reagents
All nucleic(20) cDNA(16) Primer pair(2) Other(2)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000036872 (Evidence)
Ensembl Gene Model ENSMUSG00000024639 (Evidence)
Entrez Gene 14682 (Evidence)
DFCI TC1578550, TC1598494, TC1639729, TC1707338
DoTS DT.101272903, DT.87068708, DT.94189421, DT.97358464
NIA Mouse Gene Index U043709, U370108
PDB 2BCJ, 2RGN, 3OHM, 4EKC, 4EKD, 4GNK, 3AH8, 4QJ3, 4QJ4, 4QJ5
Consensus CDS Project CCDS29684.1
International Mouse Phenotyping Consortium Status Gnaq
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036872 VEGA Gene Model | MGI Sequence Detail 254633 C57BL/6J ±  kb
transcript OTTMUST00000094727 VEGA | MGI Sequence Detail 5644 Not Applicable 
polypeptide OTTMUSP00000052744 VEGA | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(1661 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000654 G-protein alpha subunit, group Q
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008090 guanine nucleotide-binding protein G(q) subunit alpha
References
(Earliest) J:43412 Strathmann M, et al., G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates. Proc Natl Acad Sci U S A. 1990 Dec;87(23):9113-7
(Latest) J:220344 Szekeres M, et al., Endocannabinoid-mediated modulation of Gq/11 protein-coupled receptor signaling-induced vasoconstriction and hypertension. Mol Cell Endocrinol. 2015 Mar 5;403:46-56
All references(132)
Other
accession IDs
MGD-MRK-10188, MGI:1915032, MGI:1919038, MGI:2147433, MGI:2147701, MGI:2450681, MGI:2450695

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory