Gnaq
Gene Detail

Symbol Name ID

Gnaq guanine nucleotide binding protein, alpha q polypeptide MGI:95776

Synonyms

1110005L02Rik, 6230401I02Rik, Dsk1, Dsk10, Galphaq, G alpha q, Gq, GqI

Feature Type

protein coding gene

Genetic Map

Chromosome 19

11.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr19:16132831-16387463 bp, + strand From VEGA annotation of GRCm38   254633 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1566  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gnaq

Human homologs

Human Homolog		GNAQ, guanine nucleotide binding protein (G protein), q polypeptide
NCBI Gene ID		2776
neXtProt AC		NX_P50148
Human Synonyms		G-ALPHA-q, GAQ
Human Chr (Location)		9q21; chr9:80335189-80646219 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(5) Gene trapped(2) Chemically induced(2)
 

Mutant mice exhibit pigmentation anomalies affecting the ears, tail and footpads.

 

Gene Ontology (GO) classifications

All GO classifications: (52 annotations)

Process	activation of phospholipase C activity, adenylate cyclase-activating G-protein coupled receptor signaling pathway, ...
Component	caveola, cytosol, ...
Function	G-protein beta/gamma-subunit complex binding, G-protein coupled receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (56)    Tissues (44)    Images (12)
Theiler Stages: 1, 2, 3, 4, 15, 19, 20, 21, 23, 28

Assay Type	Results
RNA in situ	31
Western blot	13
RT-PCR	12

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) cDNA(16) Primer pair(2) Other(2)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000036872 (Evidence)
Ensembl Gene Model	ENSMUSG00000024639 (Evidence)
Entrez Gene	14682 (Evidence)
DFCI	TC1578550, TC1598494, TC1639729, TC1707338
DoTS	DT.101272903, DT.87068708, DT.94189421, DT.97358464
NIA Mouse Gene Index	U043709, U370108
PDB	2BCJ, 2RGN, 3OHM, 4EKC, 4EKD, 4GNK, 3AH8
Consensus CDS Project	CCDS29684.1
International Mouse Knockout Project Status	Gnaq

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036872	VEGA Gene Model | MGI Sequence Detail	254633	C57BL/6J
transcript	OTTMUST00000094727	VEGA | MGI Sequence Detail	5644	Not Applicable
polypeptide	OTTMUSP00000052744	VEGA | MGI Sequence Detail	359	Not Applicable

All sequences(40) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(1436 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000654	G-protein alpha subunit, group Q
InterPro	IPR011025	G protein alpha subunit, helical insertion
InterPro	IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Protein Ontology	PR:000008090	guanine nucleotide-binding protein G(q) subunit alpha

References

(Earliest) J:43412 Strathmann M, et al., G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates. Proc Natl Acad Sci U S A. 1990 Dec;87(23):9113-7
(Latest) J:192854 Tateyama M, et al., Binding of Gq protein stabilizes the activated state of the muscarinic receptor type 1. Neuropharmacology. 2013 Feb;65:173-81
All references(127)

Other accession IDs

MGD-MRK-10188, MGI:1915032, MGI:1919038, MGI:2147433, MGI:2147701, MGI:2450681, MGI:2450695