Gnaq Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gnaq
guanine nucleotide binding protein, alpha q polypeptide
MGI:95776

68 phenotypes from 11 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gnaq^M1J/Gnaq⁺ C57BL/6J-Gnaq^M1J/GrsrJ	abnormal dermal pigmentation	J:231947
	abnormal epidermal pigmentation	J:231947
	darkened coat color	J:231947
	increased ear pigmentation	J:231947
	increased foot pad pigmentation	J:231947
	increased tail pigmentation	J:231947
Gnaq^Mhdadsk1/Gnaq⁺ C3HeB/FeJ-Gnaq^Mhdadsk1/Ieg	abnormal skin pigmentation	J:81301
	darkened coat color	J:81301
	increased ear pigmentation	J:86685
	increased foot pad pigmentation	J:81301
	increased tail pigmentation	J:86685
Gnaq^Mhdadsk1/Gnaq^Mhdadsk1 involves: C3HeB/FeJ * C57BL/6J	darkened coat color	J:81301
	increased ear pigmentation	J:86685
	increased foot pad pigmentation	J:81301
	increased tail pigmentation	J:86685
Gnaq^Mhdadsk10/Gnaq⁺ C3HeB/FeJ-Gnaq^Dsk10	darkened coat color	J:81301
	hyperpigmentation	J:81301
	increased ear pigmentation	J:81301
	increased foot pad pigmentation	J:81301
	increased tail pigmentation	J:81301
Gnaq^Mhdadsk10/Gnaq^Mhdadsk10 C3HeB/FeJ-Gnaq^Dsk10	darkened coat color	J:81301
	hyperpigmentation	J:81301
	increased ear pigmentation	J:81301
	increased foot pad pigmentation	J:81301
	increased tail pigmentation	J:81301
Gnaq^tm1Soff/Gnaq^tm1Soff involves: 129S1/Sv	decreased platelet aggregation	J:114266
Gnaq^tm1Soff/Gnaq^tm1Soff involves: 129S1/Sv * C57BL/6	abnormal afterhyperpolarization	J:126972
	abnormal glutamate-mediated receptor currents	J:126972
	abnormal innervation	J:44598
	abnormal nervous system electrophysiology	J:126972
	abnormal platelet physiology	J:42882, J:118488
	absent long-term depression	J:70180
	ataxia	J:44598
	impaired coordination	J:44598
	increased bleeding time	J:42882
	neonatal lethality, incomplete penetrance	J:42882, J:44598
	normal nervous system phenotype	J:44598, J:126972
Gnaq^tm2.1Soff/Gnaq^tm2.1Soff involves: 129P2/OlaHsd * FVB/N	abnormal blood coagulation	J:77461
	abnormal motor coordination/balance	J:77461
	neonatal lethality, incomplete penetrance	J:77461
Tg(Myh6-Gnaq)25Gwd/0 involves: FVB/N	abnormal heart left ventricle morphology	J:144736
	cardiac hypertrophy	J:41949
	decreased cardiac muscle contractility	J:41949, J:144736
	decreased heart rate	J:41949
	decreased systemic arterial systolic blood pressure	J:41949
	decreased ventricle muscle contractility	J:41949
	heart left ventricle hypertrophy	J:41949
	increased left ventricle diastolic pressure	J:144736
	increased myocardial fiber size	J:41949
	thick interventricular septum	J:144736
Tg(Myh6-Gnaq)40Gwd/0 involves: FVB/N	premature death	J:41949
Tg(Myh6-Gnaq)#Gwd/0 involves: FVB/N	abnormal heart left ventricle morphology	J:145086
	abnormal heart ventricle morphology	J:145086
	congestive heart failure	J:145086
	decreased cardiac muscle contractility	J:145086
	dilated heart	J:145086
	enlarged heart	J:145086
	increased cardiomyocyte apoptosis	J:145086
	postnatal lethality	J:145086
Tg(Myh6-Gnaq*Q209L)44Ejne/0 involves: FVB	congestive heart failure	J:127756
	dilated cardiomyopathy	J:127756
	premature death	J:127756
Tg(Myh6-GnaqQ209L)44Ejne/Tg(Myh6-GnaqQ209L)44Ejne involves: FVB	abnormal atrial thrombosis	J:127756
	abnormal heart echocardiography feature	J:127756
	abnormal heart ventricles weight	J:127756
	abnormal myocardial fiber morphology	J:127756
	cardiac interstitial fibrosis	J:127756
	congestive heart failure	J:127756
	decreased cardiac muscle contractility	J:127756
	decreased heart rate	J:127756
	dilated cardiomyopathy	J:127756
	dilated heart ventricle	J:127756
	increased heart left atrium size	J:127756
	increased heart right atrium weight	J:127756
	increased myocardial fiber size	J:127756
	premature death	J:127756
Tg(Myh6-Gnaq*Q209L)52Ejne/? involves: FVB	abnormal atrial thrombosis	J:204274
	abnormal atrium myocardial trabeculae morphology	J:204274
	abnormal enzyme/coenzyme activity	J:204274
	abnormal heart atria weight	J:204274
	abnormal heart echocardiography feature	J:127756
	abnormal heart ventricles weight	J:127756, J:204274
	cardiac fibrosis	J:204274
	cardiac hypertrophy	J:204274
	cardiac interstitial fibrosis	J:204274
	decreased cardiac muscle contractility	J:127756
	decreased cardiac output	J:127756
	dilated cardiomyopathy	J:127756, J:204274
	dilated heart atrium	J:204274
	dilated heart ventricle	J:204274
	increased lung weight	J:204274
	increased myocardial fiber size	J:204274
	liver vascular congestion	J:204274
	myocardial fiber degeneration	J:204274
	myocardium hypertrophy	J:204274
	premature death	J:127756, J:204274
	pulmonary vascular congestion	J:204274
Tg(Myh6-GnaqQ209L/Esr1)7Rzl/0 involves: C57BL/6	abnormal cardiac muscle relaxation	J:104100
	abnormal heart echocardiography feature	J:104100
	abnormal heart morphology	J:104100
	abnormal myocardial fiber calcium currents	J:104100
	congestive heart failure	J:104100
	decreased cardiac muscle contractility	J:104100
	decreased heart rate	J:104100
	dilated cardiomyopathy	J:104100
	dilated heart ventricle	J:104100
	disheveled coat	J:104100
	distended abdomen	J:104100
	edema	J:104100
	enlarged heart	J:104100
	increased body weight	J:104100
	increased heart weight	J:104100
	premature death	J:104100
	weight loss	J:104100

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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