Tg(Myh6-Gnaq*Q209L/Esr1*)7Rzl
Transgene Detail
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Symbol: |
Tg(Myh6-Gnaq*Q209L/Esr1*)7Rzl |
Name: |
transgene insertion 7, Richard Z Lin |
MGI ID: |
MGI:6105945 |
Synonyms: |
GalphaqQ209L-hbER |
Transgene: |
Tg(Myh6-Gnaq*Q209L/Esr1*)7Rzl Location: unknown
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Alliance: |
Tg(Myh6-Gnaq*Q209L/Esr1*)7Rzl page
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Transgene Type: |
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Transgenic (Inducible, Inserted expressed sequence) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Tg(Myh6-Gnaq*Q209L/Esr1*)7Rzl expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Gnaq (MGI:95776) |
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Mutation details: The mouse alpha myosin heavy chain promoter drives the expression of a mutant Gnaq with the Q209L mutation fused to a mutant hormone-binding domain of the murine estrogen receptor in which replacement of glycine by arginine at amino acid position 525 renders the fusion proteins activity inducible by 4-hydroxytamoxifen, but unresponsive to natural estrogen. Three lines, 5, 7, and 11, were established. Line 7 is the high-expressing line.
(J:104100)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:104100 Fan G, et al., A transgenic mouse model of heart failure using inducible Galpha q. J Biol Chem. 2005 Dec 2;280(48):40337-46 |
All: |
1 reference(s) |
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