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Tg(Myh6-Gnaq*Q209L/Esr1*)7Rzl
Transgene Detail
Summary
Symbol: Tg(Myh6-Gnaq*Q209L/Esr1*)7Rzl
Name: transgene insertion 7, Richard Z Lin
MGI ID: MGI:6105945
Synonyms: GalphaqQ209L-hbER
Transgene: Tg(Myh6-Gnaq*Q209L/Esr1*)7Rzl  Location: unknown  
Alliance: Tg(Myh6-Gnaq*Q209L/Esr1*)7Rzl page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(Myh6-Gnaq*Q209L/Esr1*)7Rzl expresses 1 gene
 
Mutation detailsThe mouse alpha myosin heavy chain promoter drives the expression of a mutant Gnaq with the Q209L mutation fused to a mutant hormone-binding domain of the murine estrogen receptor in which replacement of glycine by arginine at amino acid position 525 renders the fusion proteins activity inducible by 4-hydroxytamoxifen, but unresponsive to natural estrogen. Three lines, 5, 7, and 11, were established. Line 7 is the high-expressing line. (J:104100)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:104100 Fan G, et al., A transgenic mouse model of heart failure using inducible Galpha q. J Biol Chem. 2005 Dec 2;280(48):40337-46
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/14/2023
MGI 6.22
The Jackson Laboratory