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Glra1
Gene Detail
Symbol

Name
ID
Glra1
glycine receptor, alpha 1 subunit
MGI:95747
Synonyms
B230397M16Rik, nmf11, oscillator, ot
Feature Type
protein coding gene
Genetic Map
Chromosome 11
33.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr11:55514238-55608198 bp, - strand
From VEGA annotation of GRCm38

  93961 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20083  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GLRA1
Gene Tree: Glra1

Human
homologs
GLRA1, glycine receptor, alpha 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2741
neXtProt AC: NX_P23415

Human Synonyms: HKPX1, STHE

Human Chr (Location): 5q32; chr5:151822513-151924866 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GLRA1

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Chemically induced (ENU)(1) Spontaneous(3) Targeted(8) Transgenic(2)
Genomic Mutations involving Glra1 (1)
Incidental mutations (data from APF , CvDC )
 
Mutations in this gene result in neurological defects for all alleles reported. Specific alleles also show affects on viability, reproductive performance, and/or eye and respiratory physiology.
 
Human Diseases Modeled in Mice Using Glra1 (1)    Mutations Annotated to Human Diseases (5)   
Interactions
Glra1 interacts with 125 markers (Mir10a, Mir10b, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (69 annotations)
Process acrosome reaction, action potential, ...
Component cell, cell junction, ...
Function chloride channel activity, extracellular-glycine-gated chloride channel activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (1)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase glra1 ; ZFIN glra1    NEW 
Molecular
reagents
All nucleic(17) Genomic(4) cDNA(11) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000005698 (Evidence)
Ensembl Gene Model ENSMUSG00000000263 (Evidence)
Entrez Gene 14654 (Evidence)
UniGene 89320
DFCI TC1590970, TC1621269
DoTS DT.55178581, DT.91329697
NIA Mouse Gene Index U032792
Consensus CDS Project CCDS24715.1, CCDS70190.1
International Mouse Phenotyping Consortium Status Glra1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005698 VEGA Gene Model | MGI Sequence Detail 93961 C57BL/6J ±  kb
transcript OTTMUST00000012680 VEGA | MGI Sequence Detail 2037 Not Applicable 
polypeptide OTTMUSP00000005874 VEGA | MGI Sequence Detail 457 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(3)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(478 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006028 Gamma-aminobutyric acid A receptor
InterPro IPR008127 Glycine receptor alpha
InterPro IPR008128 Glycine receptor alpha1
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology PR:000008042 glycine receptor subunit alpha-1
References
(Earliest) J:13463 Dickie MM, Oscillator. Mouse News Lett. 1967;36:39
(Latest) J:207996 Xiong W, et al., Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease. Nat Neurosci. 2014 Feb;17(2):232-9
All references(84)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-10130, MGD-MRK-13058, MGD-MRK-14516, MGI:2429917, MGI:2444829

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory