Glra1
Gene Detail

Symbol Name ID

Glra1 glycine receptor, alpha 1 subunit MGI:95747

Synonyms

B230397M16Rik, nmf11, oscillator, ot

Feature Type

protein coding gene

Genetic Map

Chromosome 11

33.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)

Sequence Map

Chr11:55514238-55608198 bp, - strand From VEGA annotation of GRCm38   93961 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20083  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Glra1

Human homologs

Human Homolog		GLRA1, glycine receptor, alpha 1
NCBI Gene ID		2741
neXtProt AC		NX_P23415
Human Synonyms		HKPX1, STHE
Human Chr (Location)		5q32; chr5:151822513-151924836 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human GLRA1

Alleles and phenotypes

All alleles(11) : Chemically induced (ENU)(1) Spontaneous(3) Targeted(7)
Incidental mutations (data from APF )
 

Mutations in this gene result in neurological defects for all alleles reported. Specific alleles also show affects on viability, reproductive performance, and/or eye and respiratory physiology.

 
Human Diseases Modeled Using Mouse Glra1 (1)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (69 annotations)

Process	acrosome reaction, action potential, ...
Component	cell, cell junction, ...
Function	chloride channel activity, extracellular-glycine-gated chloride channel activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (1)    Tissues (1)   
Theiler Stages: 23

Assay Type	Results
RNA in situ	1

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(4) cDNA(11) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000005698 (Evidence)
Ensembl Gene Model	ENSMUSG00000000263 (Evidence)
Entrez Gene	14654 (Evidence)
UniGene	89320
DFCI	TC1590970, TC1621269
DoTS	DT.55178581, DT.91329697
NIA Mouse Gene Index	U032792
Consensus CDS Project	CCDS24715.1, CCDS70190.1
International Mouse Knockout Project Status	Glra1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005698	VEGA Gene Model | MGI Sequence Detail	93961	C57BL/6J
transcript	OTTMUST00000012680	VEGA | MGI Sequence Detail	2037	Not Applicable
polypeptide	OTTMUSP00000005874	VEGA | MGI Sequence Detail	457	Not Applicable

All sequences(45) RefSeq(4) UniProt(3)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(478 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR006028	Gamma-aminobutyric acid A receptor
InterPro	IPR008127	Glycine receptor alpha
InterPro	IPR008128	Glycine receptor alpha1
InterPro	IPR006201	Neurotransmitter-gated ion-channel
InterPro	IPR018000	Neurotransmitter-gated ion-channel, conserved site
InterPro	IPR006202	Neurotransmitter-gated ion-channel ligand-binding
InterPro	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology	PR:000008042	glycine receptor subunit alpha-1

References

(Earliest) J:13463 Dickie MM, Oscillator. Mouse News Lett. 1967;36:39
(Latest) J:207996 Xiong W, et al., Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease. Nat Neurosci. 2014 Feb;17(2):232-9
All references(87)

Other accession IDs

MGD-MRK-10130, MGD-MRK-13058, MGD-MRK-14516, MGI:2429917, MGI:2444829