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Glra1
Gene Detail
 Symbol
Name
ID
Glra1
glycine receptor, alpha 1 subunit
MGI:95747
Synonyms B230397M16Rik, nmf11, oscillator, ot
Feature Type protein coding gene
Genetic Map
Chromosome 11
33.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr11:55514238-55608198 bp, - strand
From VEGA annotation of GRCm38

  93961 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20083  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Glra1

Human
homologs
Human Homolog GLRA1, glycine receptor, alpha 1
NCBI Gene ID 2741
neXtProt AC  NX_P23415
Human Synonyms  HKPX1, STHE
Human Chr (Location)  5q32; chr5:151822513-151924836 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GLRA1
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Spontaneous(3) Targeted(7)
Incidental mutations (data from APF )
 
Mutations in this gene result in neurological defects for all alleles reported. Specific alleles also show affects on viability, reproductive performance, and/or eye and respiratory physiology.
 
Human Diseases Modeled Using Mouse Glra1 (1)    Alleles Annotated to Human Diseases(3)   
Interactions
Glra1 interacts with 125 markers (Mir10a, Mir10b, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (69 annotations)
Process acrosome reaction, action potential, ...
Component cell, cell junction, ...
Function chloride channel activity, extracellular-glycine-gated chloride channel activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (1)    Tissues (1)   
Theiler Stages: 23
Assay TypeResults
RNA in situ 1
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(4) cDNA(11) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005698 (Evidence)
Ensembl Gene ModelENSMUSG00000000263 (Evidence)
Entrez Gene14654 (Evidence)
UniGene89320
DFCITC1590970, TC1621269
DoTSDT.55178581, DT.91329697
NIA Mouse Gene IndexU032792
Consensus CDS ProjectCCDS24715.1, CCDS70190.1
International Mouse Knockout Project StatusGlra1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005698 VEGA Gene Model | MGI Sequence Detail 93961 C57BL/6J ±  kb
transcript OTTMUST00000012680 VEGA | MGI Sequence Detail 2037 Not Applicable 
polypeptide OTTMUSP00000005874 VEGA | MGI Sequence Detail 457 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(3)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(478 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006028 Gamma-aminobutyric acid A receptor
InterPro IPR008127 Glycine receptor alpha
InterPro IPR008128 Glycine receptor alpha1
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology PR:000008042 glycine receptor subunit alpha-1
References (Earliest) J:13463 Dickie MM, Oscillator. Mouse News Lett. 1967;36:39
(Latest) J:207996 Xiong W, et al., Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease. Nat Neurosci. 2014 Feb;17(2):232-9
All references(87)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-10130, MGD-MRK-13058, MGD-MRK-14516, MGI:2429917, MGI:2444829

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory