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Glra1 Gene Detail
Summary
  • Symbol
    Glra1
  • Name
    glycine receptor, alpha 1 subunit
  • Synonyms
    B230397M16Rik, nmf11, oscillator, ot
  • Feature Type
    protein coding gene
  • IDs
    MGI:95747
    NCBI Gene: 14654
Location & Maps
more
  • Sequence Map
    Chr11:55514238-55608198 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      93961 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 33.12 cM
  • Mapping Data
    18 experiments
Homology
more
  • Human Ortholog
    GLRA1, glycine receptor alpha 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GLRA1, glycine receptor alpha 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HKPX1, STHE
  • Links
    NCBI Gene ID: 2741
    neXtProt AC: NX_P23415

  • Chr Location
    5q32; chr5:151822513-151924866 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 20083
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: GLRA1
  • Gene Tree
    Glra1
Human Diseases
more
  • Diseases
    1 with Glra1 mouse models; 1 with human GLRA1 associations

Human Disease Mouse Models
       Hyperekplexia, Hereditary 1; HKPX1   OMIM: 149400 View 6 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 9 alleles in 10 genetic backgrounds
    15 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Spontaneous
    4
  • Targeted
    8
  • Transgenic
    2
  • Genomic Mutations
    3 involving Glra1
  • Incidental Mutations
    APF , CvDC
Mutations in this gene result in neurological defects for all alleles reported. Specific alleles also show affects on viability, reproductive performance, and/or eye and respiratory physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    79
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1
  • Tissues
    1
  • cDNA Data
    10
  • Literature Summary
    4
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005698 VEGA Gene Model | MGI Sequence Detail 93961 C57BL/6J ±  kb
transcript OTTMUST00000012680 VEGA | MGI Sequence Detail 2037 Not Applicable  
polypeptide OTTMUSP00000005874 VEGA | MGI Sequence Detail 457 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    485 from dbSNP Build 142
  • PCR
    1
  • RFLP
    1
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008042 glycine receptor subunit alpha-1
  • InterPro Domains
    IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
    IPR008127 Glycine receptor alpha
    IPR008128 Glycine receptor alpha1
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Molecular
Reagents
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  • All nucleic 17
    Genomic 4
    cDNA 11
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10130, MGD-MRK-13058, MGD-MRK-14516, MGI:2429917, MGI:2444829
References
more
  • Summaries
    All 84
    Developmental Gene Expression 4
    Diseases 7
    Gene Ontology 25
    Phenotypes 43
  • Earliest
    J:13463 Dickie MM, Oscillator. Mouse News Lett. 1967;36:39
  • Latest
    J:228551 Aguayo LG, et al., Altered sedative effects of ethanol in mice with alpha1 glycine receptor subunits that are insensitive to Gbetagamma modulation. Neuropsychopharmacology. 2014 Oct;39(11):2538-48
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory