Phenotypes Associated with This Genotype

Genotype
MGI:5790702

• Allelic Composition: Glra1^spd-ot9J/Glra1^spd-ot9J
• Genetic Background: B6.Cg-Glra1^spd-ot9J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tonic-clonic seizures ( J:234690 )

• as early as 2 weeks of age, homozygotes have severe tonic-clonic seizures where they lay prone on one side, the whole body vibrating and the legs rigid and pointing away from the body

mortality/aging

preweaning lethality, complete penetrance ( J:234690 )

• homozygotes generally do not survive beyond 3 weeks of age

growth/size/body

decreased body size ( J:234690 )

• homozygotes are smaller than unaffected littermates

nervous system

tonic-clonic seizures ( J:234690 )

• as early as 2 weeks of age, homozygotes have severe tonic-clonic seizures where they lay prone on one side, the whole body vibrating and the legs rigid and pointing away from the body

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hyperekplexia 1		DOID:0060696	OMIM:149400	J:234690