Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables extracellularly glycine-gated chloride channel activity; glycine binding activity; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in glycinergic synaptic transmission; inhibitory postsynaptic potential; and response to alcohol. Acts upstream of or within several processes, including adult walking behavior; neuronal action potential; and regulation of respiratory gaseous exchange by nervous system process. Located in several cellular components, including external side of plasma membrane; inhibitory synapse; and postsynaptic membrane. Is active in glycinergic synapse. Is expressed in brain; brainstem; rhombomere 2; rhombomere 4; and spinal cord. Used to study hyperekplexia and hyperekplexia 1. Human ortholog(s) of this gene implicated in hyperekplexia 1. Orthologous to human GLRA1 (glycine receptor alpha 1).