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Targeted Allele Detail
Symbol: Glra1tm1Rah
Name: glycine receptor, alpha 1 subunit; targeted mutation 1, R Adron Harris
MGI ID: MGI:2676917
Gene: Glra1  Location: Chr11:55405065-55499024 bp, - strand  Genetic Position: Chr11, 33.12 cM
Alliance: Glra1tm1Rah page
Germline Transmission:  Earliest citation of germline transmission: J:85341
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Not Applicable)
Mutation:    Insertion
Mutation detailsExon 7 was modified so that the codon for serine at amino acid position 267 (AGC) changed to one that codes for glutamine (CAG) (S267Q). At the same time, a neomycin resistance gene flanked by FLP recombinase target sites was inserted. F1 heterozygotes were mated to FLP general deleter mice to remove the neo marker gene. (J:85341)
View phenotypes and curated references for all genotypes (concatenated display).
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Glra1 Mutation:  21 strains or lines available
Original:  J:85341 Findlay GS, et al., Glycine receptor knock-in mice and hyperekplexia-like phenotypes: comparisons with the null mutant. J Neurosci. 2003 Sep 3;23(22):8051-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory