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Gli3
Gene Detail
 Symbol
Name
ID
Gli3
GLI-Kruppel family member GLI3
MGI:95729
Synonyms Bph, brachyphalangy
Feature Type protein coding gene
Genetic Map
Chromosome 13
5.43 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(38)
Sequence Map
Chr13:15463235-15730026 bp, + strand
From VEGA annotation of GRCm38

  266792 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:139  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gli3

Human
homologs
Human Homolog GLI3, GLI family zinc finger 3
NCBI Gene ID 2737
neXtProt AC  NX_P10071
Human Synonyms  ACLS, GCPS, GLI3-190, GLI3FL, PAPA, PAP-A, PAPA1, PAPB, PHS, PPDIV
Human Chr (Location)  7p13; chr7:41960949-42237870 (-)  GRCh38
Disease Associations  (5) Diseases Associated with Human GLI3
Alleles
and
phenotypes
All alleles(26) : Targeted(11) Gene trapped(3) Transgenic(2) Spontaneous(4) Chemically induced(1) Radiation induced(5)
 
Homozygous mutants die perinatally with gross polydactyly, multiple craniofacial defects, and frequently, exencephaly. Heterozygotes exhibit enlarged interfrontal bone and extra preaxial digits.
 
Human Diseases Modeled Using Mouse Gli3 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (152 annotations)
Process anatomical structure development, anatomical structure formation involved in morphogenesis, ...
Component cell projection, cilium, ...
Function beta-catenin binding, chromatin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (276 records)
Data Summary: Results (773)    Tissues (453)    Images (215)
Theiler Stages: 2, 3, 4, 5, 7, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 634
Northern blot 26
Western blot 18
RT-PCR 88
RNase protection 2
cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(66) Genomic(4) cDNA(36) Primer pair(11) Other(15)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000024401 (Evidence)
Ensembl Gene ModelENSMUSG00000021318 (Evidence)
Entrez Gene14634 (Evidence)
DFCITC1584775, TC1598037
DoTSDT.101146591, DT.485325, DT.489069, DT.97355264
NIA Mouse Gene IndexU014564
Consensus CDS ProjectCCDS36603.1
International Mouse Knockout Project StatusGli3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024401 VEGA Gene Model | MGI Sequence Detail 266792 C57BL/6J ±  kb
transcript OTTMUST00000059816 VEGA | MGI Sequence Detail 8170 Not Applicable 
polypeptide OTTMUSP00000029127 VEGA | MGI Sequence Detail 1583 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(8) UniProt(5)
Polymorphisms All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs within 2kb(1376 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000008028 transcriptional activator GLI3
References (Earliest) J:12947 Lyon MF, et al., The overall rates of dominant and recessive lethal and visible mutation induced by spermatogonial X-irradiation of mice. Genet Res. 1964;5:448-467
(Latest) J:207249 Wang C, et al., Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. J Biol Chem. 2013 Oct 11;288(41):29518-29
All references(489)
Other
accession IDs
MGD-MRK-10107, MGD-MRK-1107, MGD-MRK-13222, MGD-MRK-15835, MGD-MRK-1615, MGI:2145311, MGI:2145364

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory