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Gli3
Gene Detail
Symbol

Name
ID
Gli3
GLI-Kruppel family member GLI3
MGI:95729
Synonyms
Bph, brachyphalangy
Feature Type
protein coding gene
Genetic Map
Chromosome 13
5.43 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(37)
Sequence Map
Chr13:15463235-15730026 bp, + strand
From VEGA annotation of GRCm38

  266792 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:139  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gli3

Human
homologs
Human Homolog   GLI3, GLI family zinc finger 3
NCBI Gene ID 2737
neXtProt AC  NX_P10071
Human Synonyms  ACLS, GCPS, GLI3-190, GLI3FL, PAPA, PAP-A, PAPA1, PAPB, PHS, PPDIV
Human Chr (Location)  7p13; chr7:41960949-42237870 (-)  GRCh38
Disease Associations  (6) Diseases Associated with Human GLI3
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Chemically induced (ENU)(1) Gene trapped(3) Radiation induced(5) Spontaneous(4) Targeted(14) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants die perinatally with gross polydactyly, multiple craniofacial defects, and frequently, exencephaly. Heterozygotes exhibit enlarged interfrontal bone and extra preaxial digits.
 
Human Diseases Modeled in Mice Using Gli3 (2)    Mutations Annotated to Human Diseases (2)    Phenotype Images(4)
Interactions
Gli3 interacts with 414 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (301 records)
Data Summary: Results (824)    Tissues (465)    Images (234)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 674
Northern blot 26
Western blot 36
RT-PCR 81
RNase protection 2
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(68) Genomic(4) cDNA(37) Primer pair(11) Other(16)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000024401 (Evidence)
Ensembl Gene ModelENSMUSG00000021318 (Evidence)
Entrez Gene14634 (Evidence)
DFCITC1584775, TC1598037
DoTSDT.101146591, DT.485325, DT.489069, DT.97355264
NIA Mouse Gene IndexU014564
Consensus CDS ProjectCCDS36603.1
International Mouse Knockout Project StatusGli3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024401 VEGA Gene Model | MGI Sequence Detail 266792 C57BL/6J ±  kb
transcript OTTMUST00000059816 VEGA | MGI Sequence Detail 8170 Not Applicable 
polypeptide OTTMUSP00000029127 VEGA | MGI Sequence Detail 1583 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(8) UniProt(5)
Polymorphisms
All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs within 2kb(1376 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000008028 transcriptional activator GLI3
References
(Earliest) J:12947 Lyon MF, et al., The overall rates of dominant and recessive lethal and visible mutation induced by spermatogonial X-irradiation of mice. Genet Res. 1964;5:448-467
(Latest) J:218166 Zhulyn O, et al., Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development. Dev Biol. 2015 Jan 15;397(2):191-202
All references(518)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-10107, MGD-MRK-1107, MGD-MRK-13222, MGD-MRK-15835, MGD-MRK-1615, MGI:2145311, MGI:2145364

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory