171 phenotypes from 20 alleles in 33 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
En1tm2(cre)Wrst/? Gli3tm1Alj/Gli3tm1Alj involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	abnormal cerebellar foliation	J:137136
	abnormal hindbrain morphology	J:137136
	abnormal rhombomere morphology	J:137136
	abnormal tectum morphology	J:137136
	enlarged cerebral aqueduct	J:137136
	enlarged tectum	J:137136
	normal nervous system phenotype	J:137136
Gli3add/Gli3add involves: C57BL/6 * SJL	abnormal digit development	J:11318
Gli3Mos1/Gli3+ involves: BALB/cJ * C57BL/6J	belly spot	J:136642
	hypopigmentation	J:136642
Gli3Mos1/Gli3+ Tg(Dct-lacZ)A12Jkn/0 involves: BALB/cJ * C57BL/6 * C57BL/6J * CBA	abnormal melanoblast morphology	J:136642
Gli3Mos1/Gli3Mos1 involves: BALB/cJ * C57BL/6J	abnormal melanoblast morphology	J:136642
	embryonic lethality	J:136642
Gli3Mos1/Gli3Mos1 Tg(Dct-lacZ)A12Jkn/0 involves: BALB/cJ * C57BL/6 * C57BL/6J * CBA	abnormal melanoblast morphology	J:136642
	abnormal telencephalon development	J:136642
Gli3Mos1/Gli3Xt-J involves: BALB/cJ * C3H/HeJ * C57BL/6J	postnatal lethality	J:136642
Gli3Pdn/Gli3+ involves: Jcl:ICR	abnormal digit morphology	J:12736
	polydactyly	J:12736
Gli3Pdn/Gli3Pdn involves: Jcl:ICR	abnormal cerebral cortex morphology	J:43330
	abnormal cerebral hemisphere morphology	J:38885
	abnormal digit morphology	J:12736
	abnormal hippocampal fornix morphology	J:17581
	abnormal hippocampus development	J:17581, J:38885
	abnormal hippocampus pyramidal cell layer	J:17581
	abnormal hypothalamus morphology	J:17581
	abnormal neuronal migration	J:43330
	abnormal olfactory nerve morphology	J:17581, J:38885
	abnormal radial glial cell morphology	J:43330
	abnormal stratification in cerebral cortex	J:38885
	abnormal thalamus morphology	J:17581
	absent anterior commissure	J:17581, J:38885
	absent corpus callosum	J:17581, J:38885
	absent hippocampal commissure	J:38885
	absent olfactory bulb	J:17581, J:38885, J:43330
	absent pineal gland	J:17581
	cleft palate	J:12736
	encephalomeningocele	J:17581
	exencephaly	J:12736
	eyelids open at birth	J:12736
	hydrocephaly	J:17581, J:38885
	polydactyly	J:12736
	postnatal lethality	J:12736
	short fibula	J:12736
	short tibia	J:12736
	split sternal manubrium	J:12736
	spongiform encephalopathy	J:17581, J:38885
	synostosis	J:12736
	thin cerebral cortex	J:43330
Gli3TgBR/Gli3+ involves: C57BL/6J	hydrocephaly	J:77245
	preaxial polydactyly	J:77245
Gli3TgBR/Gli3TgBR involves: C57BL/6J	abnormal craniofacial morphology	J:77245
	abnormal limb morphology	J:77245
	abnormal skeleton morphology	J:77245
	absent optic nerve	J:77245
	anophthalmia	J:77245
	exencephaly	J:77245
	herniated abdominal wall	J:77245
	microphthalmia	J:77245
	perinatal lethality	J:77245
	polydactyly	J:77245
	respiratory distress	J:77245
Gli3tm1.1Alj/Gli3tm1.1Alj involves: 129S6/SvEvTac * C57BL/6	abnormal cerebellar Purkinje cell layer	J:137136
	abnormal cerebellum morphology	J:137136
	abnormal hindbrain morphology	J:137136
	abnormal inferior colliculus morphology	J:137136
	abnormal midbrain morphology	J:137136
	abnormal midbrain-hindbrain boundary morphology	J:137136
	abnormal superior colliculus morphology	J:137136
	enlarged cerebral aqueduct	J:137136
	enlarged tectum	J:137136
	reduced cerebellar foliation	J:137136
Gli3tm1.1Zllr/Gli3tm1.2Zllr Hoxa13tm1.1(cre)Makm/Hoxa13+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	polydactyly	J:184012
Gli3tm1.2Zllr/Gli3tm1.2Zllr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal endochondral bone ossification	J:199462
	absent tibia	J:199462
	hemimelia	J:199462
	polydactyly	J:199462
Gli3tm1.2Zllr/Gli3Xt-J involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J * NMRI	abnormal brain morphology	J:184012
	abnormal eye morphology	J:184012
	polydactyly	J:184012
Gli3tm1Alj/Gli3tm1Alj Nkx3-2tm1(cre)Wez/Nkx3-2+ involves: 129S6/SvEvTac * 129S7/SvEvBrd	normal digestive/alimentary phenotype	J:199664
	normal mortality/aging	J:199664
Gli3tm1Alj/Gli3tm1Alj Tg(Nes-cre)1Kln/? involves: 129S6/SvEvTac * C57BL/6 * SJL	abnormal midbrain-hindbrain boundary morphology	J:137136
	enlarged tectum	J:137136
	normal nervous system phenotype	J:137136
Gli3tm1Blnw/Gli3tm1Blnw involves: 129S1/Sv * 129X1/SvJ * C57BL/6	polydactyly	J:118340
Gli3tm1Blnw/Gli3Xt-J involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6	polydactyly	J:118340
	postnatal lethality, complete penetrance	J:118340
Gli3tm1Urt/Gli3+ either: 129P2/OlaHsd-Gli3Tm1Urt or (involves: 129P2/OlaHsd * C57BL/6)	polydactyly	J:76496
Gli3tm1Urt/Gli3tm1Urt involves: 129P2/OlaHsd	normal pigmentation phenotype	J:136642
Gli3tm1Urt/Gli3tm1Urt involves: 129P2/OlaHsd * C57BL/6	abnormal basisphenoid bone morphology	J:76496
	abnormal bone mineralization	J:76496
	abnormal colon morphology	J:76496
	abnormal intestine morphology	J:76496
	abnormal kidney morphology	J:76496
	abnormal laryngeal cartilage morphology	J:76496
	abnormal limb morphology	J:199480
	abnormal nail morphology	J:76496
	abnormal palatine bone horizontal plate morphology	J:76496
	abnormal spine curvature	J:76496
	abnormal vertebrae morphology	J:76496
	absent adrenal gland	J:76496
	absent epiglottis	J:76496
	anal atresia	J:76496
	basisphenoid bone foramen	J:76496
	bowed radius	J:76496
	bowed tibia	J:76496
	bowed ulna	J:76496
	camptomelia	J:76496
	embryonic growth retardation	J:76496
	enlarged cranium	J:76496
	failure of endochondral bone ossification	J:199480
	interdigital webbing	J:76496
	neonatal lethality, complete penetrance	J:76496
	polydactyly	J:76496
	polysyndactyly	J:199480
	short limbs	J:76496
	short tibia	J:199480
	single kidney	J:76496
	small basisphenoid bone	J:76496
	syndactyly	J:76496
	vertebral fusion	J:76496
Gli3tm1Urt/Gli3tm2Blnw involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	polydactyly	J:121609
Gli3tm2Blnw/Gli3+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	polydactyly	J:121609
Gli3tm2Blnw/Gli3tm2Blnw involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	abnormal digit morphology	J:121609
	abnormal phalanx morphology	J:121609
	absent tibia	J:121609
	perinatal lethality, complete penetrance	J:121609
	polydactyly	J:121609
	short tibia	J:121609
	synostosis	J:121609
Gli3tm3.1Blnw/Gli3+ Tg(Prrx1-cre)1Cjt/0 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL	abnormal autopod morphology	J:199480
	abnormal forelimb zeugopod morphology	J:199480
	abnormal hindlimb morphology	J:199480
	bowed radius	J:199480
	bowed ulna	J:199480
	brachydactyly	J:199480
	decreased autopod size	J:199480
	failure of endochondral bone ossification	J:199480
	oligodactyly	J:199480
	short femur	J:199480
	short fibula	J:199480
	short forelimb	J:199480
	short humerus	J:199480
	short radius	J:199480
	short scapula	J:199480
	short tibia	J:199480
	short ulna	J:199480
	syndactyly	J:199480
Gli3tm3.1Blnw/Gli3tm3.1Blnw involves: 129S6/SvEvTac * C57BL/6 * SJL	no abnormal phenotype detected	J:199480
Gli3tm3.1Blnw/Gli3tm3.1Blnw Tg(Prrx1-cre)1Cjt/0 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL	abnormal autopod morphology	J:199480
	abnormal forelimb zeugopod morphology	J:199480
	abnormal limb morphology	J:199480
	absent radius	J:199480
	absent ulna	J:199480
	adactyly	J:199480
	failure of endochondral bone ossification	J:199480
	oligodactyly	J:199480
	perinatal lethality, incomplete penetrance	J:199480
	short fibula	J:199480
	short forelimb	J:199480
	short hindlimb	J:199480
	short humerus	J:199480
	short limbs	J:199480
	short scapula	J:199480
	short tibia	J:199480
Gli3Xt-2H/Gli3+ involves: 101/H * C3H/HeH	abnormal digit morphology	J:5053
Gli3Xt-2H/Gli3Xt-2H involves: 101/H * C3H/HeH	abnormal digit morphology	J:5053
	abnormal phalanx morphology	J:5053
	polydactyly	J:5053
Gli3Xt-3H/Gli3+ involves: 101/H * C3H/HeH	abnormal digit morphology	J:5053, J:5123
	abnormal facial morphology	J:5123
	abnormal hallux morphology	J:5053, J:5123
	abnormal interfrontal bone morphology	J:5123
	abnormal sternum morphology	J:5123
	belly spot	J:5123
	brachyphalangia	J:5053
	polysyndactyly	J:5053
	short sternum	J:5123
	sternebra fusion	J:5123
	syndactyly	J:5123
Gli3Xt-3H/Gli3Xt-3H involves: 101/H * C3H/HeH	abnormal digit morphology	J:5053
	bilateral cleft upper lip	J:5123
	bleb	J:5123
	brachyphalangia	J:64111
	edema	J:5123
	exencephaly	J:5123
	polydactyly	J:64111
	prenatal lethality	J:64111
	unilateral cleft upper lip	J:5123
Gli3Xt-4H/Gli3+ involves: 101/H * C3H/HeH	abnormal digit morphology	J:5053
Gli3Xt-4H/Gli3Xt-4H involves: 101/H * C3H/HeH	embryonic lethality before implantation, complete penetrance	J:5053
Gli3Xt-5H/Gli3+ involves: 101/H * C3H/HeH	abnormal digit morphology	J:5053
Gli3Xt-5H/Gli3Xt-5H involves: 101/H * C3H/HeH	abnormal digit morphology	J:5053
	abnormal phalanx morphology	J:5053
	polydactyly	J:5053
Gli3Xt-6H/Gli3+ involves: 101/H * C3H/HeH	abnormal digit morphology	J:5053
Gli3Xt-6H/Gli3Xt-6H involves: 101/H * C3H/HeH	abnormal digit morphology	J:5053
	abnormal phalanx morphology	J:5053
	polydactyly	J:5053
Gli3Xt-7H/Gli3Xt-7H mixed	abnormal digit morphology	J:5053
Gli3Xt-J/Gli3+ C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J	polydactyly	J:27442
Gli3Xt-J/Gli3+ involves: 129/Sv * C3H/HeJ * C57BL/6	polyphalangy	J:121609
Gli3Xt-J/Gli3+ involves: C3H * CD-1	abnormal embryonic autopod plate morphology	J:4086
	polydactyly	J:38381
Gli3Xt-J/Gli3+ involves: C3H/HeJ	polydactyly	J:207959
Gli3Xt-J/Gli3+ involves: C3H/HeJ * C57BL/6J * C57BL/6NHsd	polydactyly	J:42445
Gli3Xt-J/Gli3Xt-J B6.C3-Gli3Xt-J/J	abnormal embryonic tissue morphology	J:109476
	abnormal epidermis stratum basale morphology	J:109476
	abnormal lambdoid suture morphology	J:163175
	abnormal left lung morphology	J:42454
	abnormal mammary gland bud morphology	J:109476
	abnormal mammary line morphology	J:109476
	abnormal neurocranium morphology	J:163175
	abnormal right lung accessory lobe morphology	J:42454
	abnormal right lung caudal lobe morphology	J:42454
	abnormal right lung middle lobe morphology	J:42454
	decreased lung weight	J:42454
	edema	J:42454
	embryonic lethality during organogenesis, incomplete penetrance	J:42454
	increased embryo size	J:42454
	increased forebrain size	J:163175
	premature lambdoid suture closure	J:163175
	small lung	J:42454
	wide metopic suture	J:163175
	wide sagittal suture	J:163175
Gli3Xt-J/Gli3Xt-J involves: 129/Sv * C3H/HeJ * C57BL/6	abnormal digit morphology	J:121609
	abnormal phalanx morphology	J:121609
	absent tibia	J:121609
	polydactyly	J:121609
Gli3Xt-J/Gli3Xt-J involves: 129/Sv * C3H/HeJ * C57BL/6J	polydactyly	J:121554
Gli3Xt-J/Gli3Xt-J involves: C3H * CD-1	abnormal brain morphology	J:4086
	abnormal craniofacial development	J:4086
	abnormal cranium morphology	J:38381
	abnormal ear position	J:4086
	abnormal embryonic autopod plate morphology	J:4086
	abnormal eye development	J:4086
	abnormal long bone morphology	J:38381
	abnormal maxilla morphology	J:38381
	abnormal sternum morphology	J:38381
	abnormal tooth development	J:38381
	abnormal vertebral arch morphology	J:38381
	abnormal vibrissa morphology	J:4086
	abnormal vibrissa number	J:4086
	absent neurocranium	J:38381
	cleft palate	J:38381
	edema	J:4086
	exencephaly	J:4086
	incomplete rostral neuropore closure	J:4086
	increased diameter of humerus	J:38381
	increased diameter of radius	J:38381
	increased diameter of ulna	J:38381
	perinatal lethality, complete penetrance	J:4086
	polydactyly	J:4086, J:38381
	prenatal lethality, incomplete penetrance	J:4086
	short humerus	J:38381
	short radius	J:38381
	short tibia	J:38381
	short ulna	J:38381
	syndactyly	J:4086
Gli3Xt-J/Gli3Xt-J involves: C3H/HeJ	polydactyly	J:159210
Gli3Xt-J/Gli3Xt-J involves: C3H/HeJ * C57BL/6	abnormal left lung morphology	J:42454
	abnormal mammary gland bud morphology	J:112460
	abnormal right lung accessory lobe morphology	J:42454
	abnormal right lung caudal lobe morphology	J:42454
	normal mortality/aging	J:42454
	small lung	J:42454
Gli3Xt-J/Gli3Xt-J involves: C3H/HeJ * CD-1	abnormal sternum morphology	J:152259
	abnormal xiphoid process morphology	J:152259
	edema	J:152259
	exencephaly	J:152259
	polydactyly	J:152259
Gli3Xt-J/Gli3Xt-J involves: C3H/HeJ * NMRI	polydactyly	J:184012
Gli3Xt-J/Gli3Xt-J Tg(TCF/Lef1-lacZ)34Efu/0 involves: C3H/HeJ * C57BL/6	abnormal mammary gland embryonic development	J:112460
	abnormal mammary placode morphology	J:112460
Gt(ROSA)26Sortm3(Gli3)Amc/Gt(ROSA)26Sor+ Tg(Prrx1-cre)1Cjt/0 involves: 129 * C57BL/6J * CBA * SJL/J * Swiss Webster	decreased bone mineral density	J:143454
	polydactyly	J:143454
	short limbs	J:143454