Sequence Detail

ID/Version

Q61602 (UniProt | EBI)

Last sequence update: 2007-09-11
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Transcriptional activator GLI3;AltName: Full=GLI3 form of 190 kDa; Short=GLI3-190;AltName: Full=GLI3 full-length protein; Short=GLI3FL;Contains: RecName: Full=Transcriptional repressor GLI3R; AltName: Full=GLI3 C-terminally

Provider

SWISS-PROT

Sequence

Polypeptide 1583 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gli3	GLI-Kruppel family member GLI3	192	272	3	37

Sequence references in MGI

J:11318 Pohl TM, et al., Evidence for allelism of the recessive insertional mutation add and the dominant mouse mutation extra-toes (Xt). Development. 1990 Dec;110(4):1153-7
J:34147 Thien H, et al., Cloning and sequence analysis of the murine Gli3 cDNA. Biochim Biophys Acta. 1996 Jul 17;1307(3):267-9
J:53808 Thien H, et al., The mouse mutation Pdn (Polydactyly Nagoya) is caused by the integration of a retrotransposon into the Gli3 gene. Mamm Genome. 1999 Mar;10(3):205-9
J:60639 Wang B, et al., Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell. 2000 Feb 18;100(4):423-34
J:121609 Wang C, et al., The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. Dev Biol. 2007 May 15;305(2):460-9
J:149459 Wuelling M, et al., Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3. Dev Biol. 2009 Apr 1;328(1):40-53
J:152259 Cheung HO, et al., The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling. Sci Signal. 2009;2(76):ra29
J:152551 Endoh-Yamagami S, et al., The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr Biol. 2009 Aug 11;19(15):1320-6
J:158961 Humke EW, et al., The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev. 2010 Apr 1;24(7):670-82
J:169807 Mizugishi K, et al., Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. J Biol Chem. 2001 Jan 19;276(3):2180-8
J:207249 Wang C, et al., Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. J Biol Chem. 2013 Oct 11;288(41):29518-29
J:257035 Kim YJ, et al., WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome. EMBO Rep. 2018 Feb;19(2):269-289
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87