Ghr
Gene Detail

Symbol Name ID

Ghr growth hormone receptor MGI:95708

Synonyms

GHBP, GHR/BP

Feature Type

protein coding gene

Genetic Map

Chromosome 15

1.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)

Sequence Map

Chr15:3317760-3583492 bp, - strand From VEGA annotation of GRCm38   265733 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:134  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 zebrafish

Protein SuperFamily: growth hormone receptor
Gene Tree: Ghr

Human homologs

Human Homolog		GHR, growth hormone receptor
NCBI Gene ID		2690
neXtProt AC		NX_P10912
Human Synonyms		GHBP
Human Chr (Location)		5p13-p12; chr5:42423877-42721980 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human GHR

Alleles and phenotypes

All alleles(10) : Targeted(10)
 

Homozygotes for targeted null mutations exhibit retarded postnatal growth, proportionate dwarfism, decreased plasma insulin-like growth factor I levels, small pituitaries, reduced fecundity in females, and extended life-span.

 
Human Diseases Modeled Using Mouse Ghr (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (59 annotations)

Process	2-oxoglutarate metabolic process, activation of JAK2 kinase activity, ...
Component	cell surface, cytoplasm, ...
Function	cytokine receptor activity, growth factor binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (226)    Tissues (72)    Images (11)
Theiler Stages: 19, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	29
Northern blot	28
Western blot	1
RT-PCR	140
RNase protection	28

cDNA source data(135)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(149) Genomic(5) cDNA(137) Primer pair(3) Other(4)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000030599 (Evidence)
Ensembl Gene Model	ENSMUSG00000055737 (Evidence)
Entrez Gene	14600 (Evidence)
UniGene	3986
DFCI	TC1576161, TC1585601, TC1596129, TC1596906, TC1597006, TC1607843
DoTS	DT.101161259, DT.101372114, DT.101372115, DT.102519877, DT.532344, DT.91382251, DT.94159849, DT.97391461
NIA Mouse Gene Index	U035969
Consensus CDS Project	CCDS27358.1, CCDS37024.1
International Mouse Knockout Project Status	Ghr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030599	VEGA Gene Model | MGI Sequence Detail	265733	C57BL/6J
transcript	OTTMUST00000075779	VEGA | MGI Sequence Detail	4175	Not Applicable
polypeptide	OTTMUSP00000039789	VEGA | MGI Sequence Detail	650	Not Applicable

All sequences(85) RefSeq(6) UniProt(4)

Polymorphisms

RFLP(4) : SNPs(712 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR025871	Growth hormone-binding protein
InterPro	IPR015152	Growth hormone/erythropoietin receptor, ligand binding
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003528	Long hematopoietin receptor, single chain, conserved site
Protein Ontology	PR:000007970	growth hormone receptor

References

(Earliest) J:7060 Herington AC, et al., Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf little mouse. Endocrinology. 1983 Jun;112(6):2032-8
(Latest) J:192776 Gesing A, et al., Decreased thyroid follicle size in dwarf mice may suggest the role of growth hormone signaling in thyroid growth regulation. Thyroid Res. 2012;5(1):7
All references(172)

Other accession IDs

MGD-MRK-10070, MGI:2145937