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Ghr
Gene Detail
Symbol

Name
ID
Ghr
growth hormone receptor
MGI:95708
Synonyms
GHBP, GHR/BP
Feature Type
protein coding gene
Genetic Map
Chromosome 15
1.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)
Sequence Map
Chr15:3317760-3583492 bp, - strand
From VEGA annotation of GRCm38

  265733 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GHR
Protein SuperFamily: growth hormone receptor
Gene Tree: Ghr

Human
homologs
GHR, growth hormone receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2690
neXtProt AC: NX_P10912

Human Synonyms: GHBP, GHIP

Human Chr (Location): 5p13-p12; chr5:42423775-42721878 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human GHR

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Chemically induced (ENU)(1) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit retarded postnatal growth, proportionate dwarfism, decreased plasma insulin-like growth factor I levels, small pituitaries, reduced fecundity in females, and extended life-span.
 
Human Diseases Modeled in Mice Using Ghr (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(2)
Interactions
Ghr interacts with 326 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process 2-oxoglutarate metabolic process, activation of JAK2 kinase activity, ...
Component cell surface, cytoplasm, ...
Function cytokine receptor activity, growth factor binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (226)    Tissues (72)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
Northern blot 28
Western blot 1
RT-PCR 140
RNase protection 28
cDNA source data(135)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ghr ; ZFIN ghra, ghrb    NEW 
Molecular
reagents
All nucleic(149) Genomic(5) cDNA(137) Primer pair(3) Other(4)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000030599 (Evidence)
Ensembl Gene Model ENSMUSG00000055737 (Evidence)
Entrez Gene 14600 (Evidence)
UniGene 3986
DFCI TC1576161, TC1585601, TC1596129, TC1596906, TC1597006, TC1607843
DoTS DT.101161259, DT.101372114, DT.101372115, DT.102519877, DT.532344, DT.91382251, DT.94159849, DT.97391461
NIA Mouse Gene Index U035969
Consensus CDS Project CCDS27358.1, CCDS37024.1
International Mouse Phenotyping Consortium Status Ghr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030599 VEGA Gene Model | MGI Sequence Detail 265733 C57BL/6J ±  kb
transcript OTTMUST00000075775 VEGA | MGI Sequence Detail 2749 Not Applicable 
polypeptide OTTMUSP00000039787 VEGA | MGI Sequence Detail 650 Not Applicable 

For the selected sequences
All sequences(90) RefSeq(11) UniProt(4)
Polymorphisms
RFLP(4) : SNPs within 2kb(780 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR025871 Growth hormone-binding protein
InterPro IPR015152 Growth hormone/erythropoietin receptor, ligand binding
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003528 Long hematopoietin receptor, single chain, conserved site
Protein Ontology PR:000007970 growth hormone receptor
References
(Earliest) J:7060 Herington AC, et al., Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf little mouse. Endocrinology. 1983 Jun;112(6):2032-8
(Latest) J:220762 Dominick G, et al., Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice. Endocrinology. 2015 Feb;156(2):565-75
All references(187)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-10070, MGI:2145937

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory