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Ghr Gene Detail
Summary
  • Symbol
    Ghr
  • Name
    growth hormone receptor
  • Synonyms
    GHBP, GHR/BP
  • Feature Type
    protein coding gene
  • IDs
    MGI:95708
    NCBI Gene: 14600
  • Alliance
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:3347237-3612834 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 1.84 cM
  • Mapping Data
    23 experiments
Strain
Comparison
more
  • SNPs within 2kb
    752 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95708
protein coding gene Chr15:3347237-3612974 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021682
protein coding gene Chr15:171518-443552 (-)
A/J MGP_AJ_G0021642
protein coding gene Chr15:181824-454815 (-)
AKR/J MGP_AKRJ_G0021620
protein coding gene Chr15:183872-457471 (-)
BALB/cJ MGP_BALBcJ_G0021649
protein coding gene Chr15:175799-444617 (-)
C3H/HeJ MGP_C3HHeJ_G0021425
protein coding gene Chr15:162788-435364 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022088
protein coding gene Chr15:213640-502525 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019626
protein coding gene Chr15:142484-396402 (-)
CAST/EiJ MGP_CASTEiJ_G0020941
protein coding gene Chr15:223062-499647 (-)
CBA/J MGP_CBAJ_G0021394
protein coding gene Chr15:205190-499427 (-)
DBA/2J MGP_DBA2J_G0021518
protein coding gene Chr15:159132-424633 (-)
FVB/NJ MGP_FVBNJ_G0021496
protein coding gene Chr15:148991-410516 (-)
LP/J MGP_LPJ_G0021585
protein coding gene Chr15:151746-424632 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021522
protein coding gene Chr15:207595-503256 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022111
protein coding gene Chr15:175233-452792 (-)
PWK/PhJ MGP_PWKPhJ_G0020685
protein coding gene Chr15:212195-481683 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020523
protein coding gene Chr15:238945-521176 (-)
WSB/EiJ MGP_WSBEiJ_G0020997
protein coding gene Chr15:159423-432510 (-)



Homology
more
  • Human Ortholog
    GHR, growth hormone receptor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GHR, growth hormone receptor
  • Synonyms
    GHBP, GHIP
  • Links
    NCBI Gene ID: 2690
    neXtProt AC: NX_P10912
    UniProt: P10912

  • Chr Location
    5p13.1-p12; chr5:42423439-42721878 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with Ghr mouse models; 6 with human GHR associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    142 phenotypes from 10 alleles in 13 genetic backgrounds
    8 phenotypes from multigenic genotypes
    6 images
    184 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit retarded postnatal growth, proportionate dwarfism, decreased plasma insulin-like growth factor I levels, small pituitaries, reduced fecundity in females, and extended life-span.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14600 NCBI Gene Model | MGI Sequence Detail 265598 C57BL/6J ±  kb
    transcript NM_010284 RefSeq | MGI Sequence Detail 4302 ZRU/MplStud  
    polypeptide P16882 UniProt | EBI | MGI Sequence Detail 650 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 158
      Genomic 5
      cDNA 138
      Primer pair 7
      Other 8

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10070, MGI:2145937
    References
    more
    • Summaries
      All 301
      Developmental Gene Expression 23
      Diseases 3
      Gene Ontology 12
      Phenotypes 184
    • Earliest
      J:7060 Herington AC, et al., Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf little mouse. Endocrinology. 1983 Jun;112(6):2032-8
    • Latest
      J:342007 Apaydin T, et al., WIP1 is a novel specific target for growth hormone action. iScience. 2023 Nov 17;26(11):108117

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory