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Ghr
Gene Detail
 Symbol
Name
ID
Ghr
growth hormone receptor
MGI:95708
Synonyms GHBP, GHR/BP
Feature Type protein coding gene
Genetic Map
Chromosome 15
1.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)
Sequence Map
Chr15:3317760-3583492 bp, - strand
From VEGA annotation of GRCm38

  265733 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: growth hormone receptor
Gene Tree: Ghr

Human
homologs
Human Homolog GHR, growth hormone receptor
NCBI Gene ID 2690
neXtProt AC  NX_P10912
Human Synonyms  GHBP
Human Chr (Location)  5p13-p12; chr5:42423475-42721878 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human GHR
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit retarded postnatal growth, proportionate dwarfism, decreased plasma insulin-like growth factor I levels, small pituitaries, reduced fecundity in females, and extended life-span.
 
Human Diseases Modeled Using Mouse Ghr (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)
Interactions
Ghr interacts with 327 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process 2-oxoglutarate metabolic process, activation of JAK2 kinase activity, ...
Component cell surface, cytoplasm, ...
Function cytokine receptor activity, growth factor binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (226)    Tissues (72)    Images (11)
Theiler Stages: 19, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 29
Northern blot 28
Western blot 1
RT-PCR 140
RNase protection 28
cDNA source data(135)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(149) Genomic(5) cDNA(137) Primer pair(3) Other(4)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000030599 (Evidence)
Ensembl Gene ModelENSMUSG00000055737 (Evidence)
Entrez Gene14600 (Evidence)
UniGene3986
DFCITC1576161, TC1585601, TC1596129, TC1596906, TC1597006, TC1607843
DoTSDT.101161259, DT.101372114, DT.101372115, DT.102519877, DT.532344, DT.91382251, DT.94159849, DT.97391461
NIA Mouse Gene IndexU035969
Consensus CDS ProjectCCDS27358.1, CCDS37024.1
International Mouse Knockout Project StatusGhr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030599 VEGA Gene Model | MGI Sequence Detail 265733 C57BL/6J ±  kb
transcript OTTMUST00000075779 VEGA | MGI Sequence Detail 4175 Not Applicable 
polypeptide OTTMUSP00000039789 VEGA | MGI Sequence Detail 650 Not Applicable 

For the selected sequences
All sequences(94) RefSeq(15) UniProt(4)
Polymorphisms RFLP(4) : SNPs within 2kb(780 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR025871 Growth hormone-binding protein
InterPro IPR015152 Growth hormone/erythropoietin receptor, ligand binding
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003528 Long hematopoietin receptor, single chain, conserved site
Protein Ontology PR:000007970 growth hormone receptor
References (Earliest) J:7060 Herington AC, et al., Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf little mouse. Endocrinology. 1983 Jun;112(6):2032-8
(Latest) J:210636 Levine ME, et al., Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab. 2014 Mar 4;19(3):407-17
All references(181)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-10070, MGI:2145937

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory