|
Symbol Name ID |
Ghr
growth hormone receptor MGI:95708 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased LDL cholesterol concentration |
Hypercholesterolemia |
Hypoglycemia |
Neonatal hypoglycemia |
Type II diabetes mellitus |
Insulin resistance |
Decreased serum insulin-like growth factor 1 |
| Disease(s) Associated with GHR | |||||||
| familial hypercholesterolemia | |||||||
| isolated growth hormone deficiency | |||||||
| Laron syndrome | |||||||
| type 2 diabetes mellitus |
| Mouse Phenotypes | homeostasis/metabolism phenotype |
decreased insulin secretion |
abnormal blood homeostasis |
decreased circulating glucose level |
hypoglycemia |
increased circulating glucose level |
hyperglycemia |
decreased circulating testosterone level |
decreased circulating estradiol level |
decreased circulating glucagon level |
increased circulating corticosterone level |
decreased circulating luteinizing hormone level |
increased circulating prolactin level |
decreased circulating insulin level |
increased circulating insulin level |
decreased circulating insulin-like growth factor I level |
increased circulating insulin-like growth factor I level |
increased circulating leptin level |
increased circulating growth hormone level |
decreased circulating thyroxine level |
decreased circulating triiodothyronine level |
abnormal circulating lipid level |
decreased circulating HDL cholesterol level |
decreased circulating LDL cholesterol level |
decreased circulating VLDL cholesterol level |
decreased circulating cholesterol level |
increased circulating free fatty acids level |
decreased circulating triglyceride level |
increased circulating interleukin-6 level |
increased circulating creatine kinase level |
increased circulating serum albumin level |
decreased body temperature |
abnormal fluid regulation |
impaired glucose tolerance |
increased insulin sensitivity |
decreased circulating adiponectin level |
increased circulating adiponectin level |
decreased serotonin level |
decreased triiodothyronine level |
increased circulating chloride level |
decreased liver triglyceride level |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||
| Ghrtm1.1Jero/Ghrtm1.1Jero | ||||||||||||||||||||||||||||||||||||||||||
| Ghrtm1Arge/Ghrtm1Arge | ||||||||||||||||||||||||||||||||||||||||||
| Ghrtm1Jjk/Ghrtm1Jjk | ||||||||||||||||||||||||||||||||||||||||||
| Ghrtm1Mwat/Ghrtm1Mwat | ||||||||||||||||||||||||||||||||||||||||||
| Ghrtm2Mwat/Ghrtm2Mwat | ||||||||||||||||||||||||||||||||||||||||||
| Ghrtm1.1Dlr/Ghrtm1.1Dlr Tg(Ins2-cre)25Mgn/0 (conditional) |
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| Ghrtm1.1Dlr/Ghrtm1.1Dlr Tg(Ins2-cre)23Herr/0 (conditional) |
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| Ghrtm1.1Masp/Ghrtm1.1Masp Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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| Ghrtm1c(KOMP)Wtsi/Ghrtm1c(KOMP)Wtsi Tg(Fabp4-cre)1Rev/0 (conditional) |
* | |||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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