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Gh
Gene Detail
Symbol

Name
ID
Gh
growth hormone
MGI:95707
Feature Type
protein coding gene
Genetic Map
Chromosome 11
68.89 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr11:106300271-106301865 bp, - strand
From VEGA annotation of GRCm38

  1595 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47932  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: CSHL1
Protein SuperFamily: prolactin/lactogen/growth hormone
Gene Tree: Gh

Human
homologs
CSHL1, chorionic somatomammotropin hormone-like 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1444
neXtProt AC: NX_Q14406

Human Synonyms: CS-5, CSHP1, CSL, hCS-L

Human Chr (Location): 17q24.2; chr17:63909602-63911323 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Targeted(2) Transgenic(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced allele exhibit dwarfism, an increased percentage of body white and brown fat, elevated plasma ghrelin levels, pituitary hypoplasia, small liver, delayed sexual maturation, and reduced fertility. Heterozygotes display a less pronounced phenotype.
 
Human Diseases Modeled in Mice Using Gh (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Gh interacts with 9 markers (Mir141, Mir200a, Mir200b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cellular response to insulin stimulus, glucose transport, ...
Component cytosol, extracellular region, ...
Function growth hormone receptor binding, hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (94 records)
Data Summary: Results (109)    Tissues (79)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 41
Northern blot 4
Western blot 6
RT-PCR 48
cDNA source data(274)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA GH ; Xenbase LOC100492540 ; ZFIN gh1    NEW 
Molecular
reagents
All nucleic(282) Genomic(1) cDNA(275) Primer pair(4) Other(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000003423 (Evidence)
Ensembl Gene Model ENSMUSG00000020713 (Evidence)
Entrez Gene 14599 (Evidence)
UniGene 343934
DFCI TC1572288, TC1731042
DoTS DT.40185492, DT.87036084, DT.87039644, DT.94213439
NIA Mouse Gene Index U033540
Consensus CDS Project CCDS25554.1
International Mouse Phenotyping Consortium Status Gh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003423 VEGA Gene Model | MGI Sequence Detail 1595 C57BL/6J ±  kb
transcript OTTMUST00000007211 VEGA | MGI Sequence Detail 862 Not Applicable 
polypeptide OTTMUSP00000003470 VEGA | MGI Sequence Detail 216 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(3) : SNPs within 2kb(57 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR001400 Somatotropin hormone
InterPro IPR018116 Somatotropin hormone, conserved site
Protein Ontology PR:000007968 somatotropin
References
(Earliest) J:7935 Linzer DI, et al., Nucleotide sequence of mouse prolactin and growth hormone mRNAs and expression of these mRNAs during pregnancy. J Biol Chem. 1985 Aug 15;260(17):9574-9
(Latest) J:218295 Mortensen AH, et al., Deletion of OTX2 in neural ectoderm delays anterior pituitary development. Hum Mol Genet. 2015 Feb 15;24(4):939-53
All references(199)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10069

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory