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Gh
Gene Detail
 Symbol
Name
ID
Gh
growth hormone
MGI:95707
Feature Type protein coding gene
Genetic Map
Chromosome 11
68.89 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr11:106300271-106301865 bp, - strand
From VEGA annotation of GRCm38

  1595 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47932  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: prolactin/lactogen/growth hormone
Gene Tree: Gh

Human
homologs
Human Homolog CSHL1, chorionic somatomammotropin hormone-like 1
NCBI Gene ID 1444
neXtProt AC  NX_Q14406
Human Synonyms  CS-5, CSHP1, CSL, hCS-L
Human Chr (Location)  17q24.2; chr17:63909605-63911258 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Chemically induced (ENU)(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced allele exhibit dwarfism, an increased percentage of body white and brown fat, elevated plasma ghrelin levels, pituitary hypoplasia, small liver, delayed sexual maturation, and reduced fertility. Heterozygotes display a less pronounced phenotype.
 
Human Diseases Modeled Using Mouse Gh (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Gh interacts with 9 markers (Mir141, Mir200a, Mir200b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cellular response to insulin stimulus, glucose transport, ...
Component cytosol, extracellular region, ...
Function growth hormone receptor binding, hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (87 records)
Data Summary: Results (108)    Tissues (78)    Images (10)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 9
RNA in situ 41
Northern blot 4
Western blot 6
RT-PCR 48
cDNA source data(274)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(282) Genomic(1) cDNA(275) Primer pair(4) Other(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000003423 (Evidence)
Ensembl Gene ModelENSMUSG00000020713 (Evidence)
Entrez Gene14599 (Evidence)
UniGene343934
DFCITC1572288, TC1731042
DoTSDT.40185492, DT.87036084, DT.87039644, DT.94213439
NIA Mouse Gene IndexU033540
Consensus CDS ProjectCCDS25554.1
International Mouse Knockout Project StatusGh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003423 VEGA Gene Model | MGI Sequence Detail 1595 C57BL/6J ±  kb
transcript OTTMUST00000007211 VEGA | MGI Sequence Detail 862 Not Applicable 
polypeptide OTTMUSP00000003470 VEGA | MGI Sequence Detail 216 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(2)
Polymorphisms RFLP(3) : SNPs within 2kb(57 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR001400 Somatotropin hormone
InterPro IPR018116 Somatotropin hormone, conserved site
Protein Ontology PR:000007968 somatotropin
References (Earliest) J:19261 George DL, et al., The genes for growth hormone and chorionic somatomammotropin are on the long arm of human chromosome 17 in region q21 to qter. Hum Genet. 1981;57(2):138-41
(Latest) J:203060 Villares R, et al., Growth hormone prevents the development of autoimmune diabetes. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):E4619-27
All references(208)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10069

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory