Gh
Gene Detail

Symbol Name ID

Gh growth hormone MGI:95707

Feature Type

protein coding gene

Genetic Map

Chromosome 11

68.89 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(17)

Sequence Map

Chr11:106300271-106301865 bp, - strand From VEGA annotation of GRCm38   1595 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:47932  Vertebrate Homology Class
1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: prolactin/lactogen/growth hormone
Gene Tree: Gh

Alleles and phenotypes

All alleles(2) : Targeted(1) Chemically induced(1)
 

Mice homozygous for an ENU-induced allele exhibit dwarfism, an increased percentage of body white and brown fat, elevated plasma ghrelin levels, pituitary hypoplasia, small liver, delayed sexual maturation, and reduced fertility. Heterozygotes display a less pronounced phenotype.

 
Human Diseases Modeled Using Mouse Gh (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	cellular response to insulin stimulus, glucose transport, ...
Component	cytosol, extracellular region, ...
Function	growth hormone receptor binding, hormone activity, ...

External Resources: FuncBase

Expression

Literature Summary: (83 records)
Data Summary: Results (106)    Tissues (77)    Images (8)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	7
RNA in situ	41
Northern blot	4
Western blot	6
RT-PCR	48

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) Genomic(1) cDNA(15) Primer pair(4) Other(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000003423 (Evidence)
Ensembl Gene Model	ENSMUSG00000020713 (Evidence)
Entrez Gene	14599 (Evidence)
DFCI	TC1572288, TC1731042
DoTS	DT.40185492, DT.87036084, DT.87039644, DT.94213439
NIA Mouse Gene Index	U033540
Consensus CDS Project	CCDS25554.1
International Mouse Knockout Project Status	Gh

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003423	VEGA Gene Model | MGI Sequence Detail	1595	C57BL/6J
transcript	OTTMUST00000007211	VEGA | MGI Sequence Detail	862	Not Applicable
polypeptide	OTTMUSP00000003470	VEGA | MGI Sequence Detail	216	Not Applicable

All sequences(34) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(3) : SNPs(4 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012351	Four-helical cytokine, core
InterPro	IPR009079	Four-helical cytokine-like, core
InterPro	IPR001400	Somatotropin hormone
InterPro	IPR018116	Somatotropin hormone, conserved site
Protein Ontology	PR:000007968	somatotropin

References

(Earliest) J:19261 George DL, et al., The genes for growth hormone and chorionic somatomammotropin are on the long arm of human chromosome 17 in region q21 to qter. Hum Genet. 1981;57(2):138-41
(Latest) J:194130 Appelbe OK, et al., Conditional deletions refine the embryonic requirement for Dlk1. Mech Dev. 2013 Feb;130(2-3):143-59
All references(199)

Other accession IDs

MGD-MRK-10069