Automated description from the Alliance of Genome Resources (Release 8.3.0)
Predicted to enable growth factor activity; growth hormone receptor binding activity; and hormone activity. Predicted to be involved in several processes, including growth hormone receptor signaling pathway; positive regulation of receptor signaling pathway via JAK-STAT; and response to nutrient levels. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including early conceptus; gut; hemolymphoid system; male reproductive system; and pituitary gland. Used to study isolated growth hormone deficiency type II. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune polyendocrine syndrome type 1; diabetic retinopathy; isolated growth hormone deficiency (multiple); and progeria. Orthologous to several human genes including CSH1 (chorionic somatomammotropin hormone 1); CSH2 (chorionic somatomammotropin hormone 2); and GH1 (growth hormone 1).
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