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Gfap
Gene Detail
 Symbol
Name
ID
Gfap
glial fibrillary acidic protein
MGI:95697
STS D11Nds5, D11Nds7
Feature Type protein coding gene
Genetic Map
Chromosome 11
66.48 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr11:102887336-102900912 bp, - strand
From VEGA annotation of GRCm38

  13577 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1554  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gfap

Human
homologs
Human Homolog GFAP, glial fibrillary acidic protein
NCBI Gene ID 2670
neXtProt AC  NX_P14136
Human Chr (Location)  17q21; chr17:44905626-44915552 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GFAP
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Targeted(13)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations show reduced astrocyte-associated intermediate filaments, enhanced long-term potentiation and impaired eye-blink conditioning. Aged mutants may show hydrocephaly, reduced myelination and impaired blood-brain barrier.
 
Human Diseases Modeled Using Mouse Gfap (1)    Alleles Annotated to Human Diseases(3)   
Interactions
Gfap interacts with 184 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process astrocyte development, Bergmann glial cell differentiation, ...
Component astrocyte end-foot, astrocyte projection, ...
Function integrin binding, kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (582 records)
Data Summary: Results (417)    Tissues (205)    Images (119)
Theiler Stages: 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 135
RNA in situ 163
Northern blot 22
Western blot 1
RT-PCR 82
Nuclease S1 14
cDNA source data(248)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(271) Genomic(5) cDNA(248) Primer pair(16) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000003084 (Evidence)
Ensembl Gene ModelENSMUSG00000020932 (Evidence)
Entrez Gene14580 (Evidence)
UniGene1239
DFCITC1640428, TC1648992
DoTSDT.94156536, DT.94245606
NIA Mouse Gene IndexU033490
Consensus CDS ProjectCCDS25507.1, CCDS48950.1
International Mouse Knockout Project StatusGfap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003084 VEGA Gene Model | MGI Sequence Detail 13577 C57BL/6J ±  kb
transcript OTTMUST00000006346 VEGA | MGI Sequence Detail 2648 Not Applicable 
polypeptide OTTMUSP00000002989 VEGA | MGI Sequence Detail 430 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(7) UniProt(2)
Polymorphisms All PCR and RFLP(19) : PCR(14) RFLP(5) SNPs within 2kb(166 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006821 Intermediate filament head, DNA-binding domain
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
Protein Ontology PR:000007939 glial fibrillary acidic protein
References (Earliest) J:7424 Lewis SA, et al., Sequence of a cDNA clone encoding mouse glial fibrillary acidic protein: structural conservation of intermediate filaments. Proc Natl Acad Sci U S A. 1984 May;81(9):2743-6
(Latest) J:211048 Walker AK, et al., Astrocytic TDP-43 pathology in Alexander disease. J Neurosci. 2014 May 7;34(19):6448-58
All references(720)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-10055, MGI:2144272

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory