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Gfap
Gene Detail
Symbol

Name
ID
Gfap
glial fibrillary acidic protein
MGI:95697
Feature Type
protein coding gene
Genetic Map
Chromosome 11
66.48 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr11:102887336-102900912 bp, - strand
From VEGA annotation of GRCm38

  13577 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1554  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: GFAP
Gene Tree: Gfap

Human
homologs
GFAP, glial fibrillary acidic protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2670
neXtProt AC: NX_P14136

Human Synonyms: ALXDRD

Human Chr (Location): 17q21; chr17:44905626-44915552 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GFAP

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Targeted(14) Transgenic(3)
Genomic Mutations involving Gfap (1)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations show reduced astrocyte-associated intermediate filaments, enhanced long-term potentiation and impaired eye-blink conditioning. Aged mutants may show hydrocephaly, reduced myelination and impaired blood-brain barrier.
 
Human Diseases Modeled in Mice Using Gfap (1)    Mutations Annotated to Human Diseases (5)   
Interactions
Gfap interacts with 183 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process astrocyte development, Bergmann glial cell differentiation, ...
Component astrocyte end-foot, astrocyte projection, ...
Function integrin binding, kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (644 records)
Data Summary: Results (458)    Tissues (218)    Images (136)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 173
RNA in situ 166
Northern blot 22
Western blot 1
RT-PCR 82
Nuclease S1 14
cDNA source data(248)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA GFAP ZFIN gfap    NEW 
Molecular
reagents
All nucleic(273) Genomic(5) cDNA(249) Primer pair(17) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000003084 (Evidence)
Ensembl Gene Model ENSMUSG00000020932 (Evidence)
Entrez Gene 14580 (Evidence)
UniGene 1239
DFCI TC1640428, TC1648992
DoTS DT.94156536, DT.94245606
NIA Mouse Gene Index U033490
Consensus CDS Project CCDS25507.1, CCDS48950.1
International Mouse Phenotyping Consortium Status Gfap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003084 VEGA Gene Model | MGI Sequence Detail 13577 C57BL/6J ±  kb
transcript OTTMUST00000006346 VEGA | MGI Sequence Detail 2648 Not Applicable 
polypeptide OTTMUSP00000002989 VEGA | MGI Sequence Detail 430 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(5) UniProt(2)
Polymorphisms
All PCR and RFLP(19) : PCR(14) RFLP(5) SNPs within 2kb(166 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027701 Glial fibrillary acidic protein
InterPro IPR006821 Intermediate filament head, DNA-binding domain
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
Protein Ontology PR:000007939 glial fibrillary acidic protein
References
(Earliest) J:7424 Lewis SA, et al., Sequence of a cDNA clone encoding mouse glial fibrillary acidic protein: structural conservation of intermediate filaments. Proc Natl Acad Sci U S A. 1984 May;81(9):2743-6
(Latest) J:222780 Defourny J, et al., Cochlear supporting cell transdifferentiation and integration into hair cell layers by inhibition of ephrin-B2 signalling. Nat Commun. 2015;6:7017
All references(786)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-10055, MGI:2144272

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory