Gfap
Gene Detail

Symbol Name ID

Gfap glial fibrillary acidic protein MGI:95697

STS

D11Nds5, D11Nds7

Feature Type

protein coding gene

Genetic Map

Chromosome 11

66.48 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(21)

Sequence Map

Chr11:102887336-102900912 bp, - strand From VEGA annotation of GRCm38   13577 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Gfap ± 2 cM)

Gene Tree: Gfap

Human ortholog

GFAP glial fibrillary acidic protein NCBI Gene ID 2670
Human Chr17:42982993-42992914 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human GFAP (1)

Alleles and phenotypes

All alleles(13) : Targeted(13)
 

Homozygotes for targeted null mutations show reduced astrocyte-associated intermediate filaments, enhanced long-term potentiation and impaired eye-blink conditioning. Aged mutants may show hydrocephaly, reduced myelination and impaired blood-brain barrier.

 
Human Diseases Modeled Using Mouse Gfap (2)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	astrocyte development, Bergmann glial cell differentiation, ...
Component	astrocyte projection, cell body, ...
Function	integrin binding, kinase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (504 records)
Data Summary: Results (375)    Tissues (186)    Images (70)
Theiler Stages: 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	93
RNA in situ	163
Northern blot	22
Western blot	1
RT-PCR	82
Nuclease S1	14

cDNA source data(248)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(271) Genomic(5) cDNA(248) Primer pair(16) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000003084 (Evidence)
Ensembl Gene Model	ENSMUSG00000020932 (Evidence)
Entrez Gene	14580 (Evidence)
UniGene	1239
DFCI	TC1640428, TC1648992
DoTS	DT.94156536, DT.94245606
NIA Mouse Gene Index	U033490
Consensus CDS Project	CCDS25507.1, CCDS48950.1
International Mouse Knockout Project Status	Gfap

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003084	VEGA Gene Model | MGI Sequence Detail	13577	C57BL/6J
transcript	OTTMUST00000006346	VEGA | MGI Sequence Detail	2648	Not Applicable
polypeptide	OTTMUSP00000002989	VEGA | MGI Sequence Detail	430	Not Applicable

All sequences(47) RefSeq(4) UniProt(2)

Polymorphisms

All PCR and RFLP(19) : PCR(14) RFLP(5) SNPs(83 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016044	Filament
InterPro	IPR006821	Intermediate filament head, DNA-binding domain
InterPro	IPR001664	Intermediate filament protein
InterPro	IPR018039	Intermediate filament protein, conserved site
Protein Ontology	PR:000007939	glial fibrillary acidic protein

References

(Earliest) J:7424 Lewis SA, et al., Sequence of a cDNA clone encoding mouse glial fibrillary acidic protein: structural conservation of intermediate filaments. Proc Natl Acad Sci U S A. 1984 May;81(9):2743-6
(Latest) J:192870 Biau S, et al., Gastrointestinal defects of the Gas1 mutant involve dysregulated Hedgehog and Ret signaling. Biol Open. 2013;2:144-155
All references(632)

Other accession IDs

MGD-MRK-10055, MGI:2144272