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Phenotypes Associated with This Genotype
Genotype
MGI:3850536
Allelic
Composition		 Gfaptm2Mes/Gfap+
Tg(GFAP)10Mes/0
Genetic
Background		 involves: 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm2Mes mutation (2 available); any Gfap mutation (49 available)
Tg(GFAP)10Mes mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:146191 )
• all animals die by under 50 days of age (most die around 30 days)

nervous system
abnormal hippocampus morphology ( J:146191 )
• Rosenthal fiber formation is observed

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alexander disease DOID:4252 OMIM:203450
 J:146191

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory