Phenotypes Associated with This Genotype

Genotype
MGI:3692743

• Allelic Composition: Gfap^tm3Mes/Gfap⁺
• Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:114689 )

nervous system

abnormal astrocyte morphology ( J:114689 )

• develop Rosenthal fibers, especially within the hippocampus, olfactory bulb, corpus callosum, and rostral extension, as well as in subpial, perivascular and periventricular regions

• exhibit fewer Rosenthal fibers than seen in heterozygous Gfap^tm2Hgmn mutants

gliosis ( J:114689 )

cellular

abnormal astrocyte morphology ( J:114689 )

• develop Rosenthal fibers, especially within the hippocampus, olfactory bulb, corpus callosum, and rostral extension, as well as in subpial, perivascular and periventricular regions

• exhibit fewer Rosenthal fibers than seen in heterozygous Gfap^tm2Hgmn mutants

gliosis ( J:114689 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alexander disease		DOID:4252	OMIM:203450	J:114689