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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gfap
glial fibrillary acidic protein
MGI:95697
25 phenotypes from 10 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gfaptm1Ito/Gfaptm1Ito
involves: 129P2/OlaHsd * C57BL/6J 		abnormal excitatory postsynaptic potential J:32098
abnormal eye blink conditioning behavior J:32098
normal behavior/neurological phenotype J:32098
normal nervous system phenotype J:32098
reduced long-term depression J:32098
Gfaptm1Ldtk/Gfaptm1Ldtk
involves: 129P2/OlaHsd * C57BL/6 		abnormal astrocyte morphology J:77630
abnormal blood vessel morphology J:77630
abnormal blood-brain barrier function J:77630
abnormal brain white matter morphology J:77630
abnormal myelination J:77630
abnormal oligodendrocyte morphology J:77630
abnormal oligodendrocyte physiology J:77630
decreased corpus callosum size J:77630
non-obstructive hydrocephaly J:77630
Gfaptm1Mes/Gfaptm1Mes
either: (involves: 129S7/SvEvBrd * 129X1/SvJ) or (involves: 129S7/SvEvBrd * C57BL/6) 		abnormal astrocyte morphology J:64290
enhanced long-term potentiation J:64290
increased susceptibility to injury J:48767
Gfaptm1Pkny/Gfaptm1Pkny
involves: 129P2/OlaHsd * C57BL/6J 		abnormal astrocyte morphology J:25093, J:125659
normal behavior/neurological phenotype J:25093
normal cellular phenotype J:125659
normal digestive/alimentary phenotype J:25093
normal nervous system phenotype J:25093, J:125659
Gfaptm2Ito/Gfaptm2Ito
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 		normal nervous system phenotype J:78341
Gfaptm2Mes/Gfap+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N 		abnormal astrocyte morphology J:114689
abnormal brain iron level J:114689
decreased body size J:114689
gliosis J:114689
increased susceptibility to pharmacologically induced seizures J:114689
Gfaptm2Mes/Gfaptm2Mes
involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N 		abnormal astrocyte morphology J:114689
decreased body weight J:114689
gliosis J:114689
Gfaptm3Ito/Gfaptm3Ito
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 		abnormal astrocyte morphology J:78341
Gfaptm3Mes/Gfap+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N 		abnormal astrocyte morphology J:114689
decreased body size J:114689
gliosis J:114689
Gfaptm3Mes/Gfaptm3Mes
involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N 		abnormal astrocyte morphology J:114689
decreased body weight J:114689
gliosis J:114689
Gfaptm4Ito/Gfaptm4Ito
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 		abnormal astrocyte morphology J:78341
abnormal CNS glial cell morphology J:78341
Gfaptm5Ito/Gfaptm5Ito
involves: 129P2/OlaHsd * C57BL/6J 		no abnormal phenotype detected J:99896
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory