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Gc
Gene Detail
 Symbol
Name
ID
Gc
group specific component
MGI:95669
Synonyms DBP, vitamin D binding protein
Feature Type protein coding gene
Genetic Map
Chromosome 5
44.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:89417511-89457898 bp, - strand
From NCBI annotation of GRCm38

  40388 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:486  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: vitamin D-binding protein
Gene Tree: Gc

Human
homologs
Human Homolog GC, group-specific component (vitamin D binding protein)
NCBI Gene ID 2638
neXtProt AC  NX_P02774
Human Synonyms  DBP, DBP/GC, GRD3, HEL-S-51, VDBG, VDBP
Human Chr (Location)  4q12-q13; chr4:71741678-71805520 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene show an essentially normal phenotype. However, they have an increased sensitivity to vitamin D deficiency in the diet.
 
Interactions
Gc interacts with 53 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process transport, vitamin D metabolic process, ...
Component axon, blood microparticle, ...
Function actin binding, calcidiol binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (3)    Tissues (3)    Images (1)
Theiler Stages: 17, 20, 22
Assay TypeResults
RNA in situ 1
RT-PCR 2
cDNA source data(189)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(195) Genomic(2) cDNA(191) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000035540 (Evidence)
Entrez Gene14473 (Evidence)
UniGene196595
DFCITC1574034, TC1767196
DoTSDT.97362586
NIA Mouse Gene IndexU026376
Consensus CDS ProjectCCDS19407.1
International Mouse Knockout Project StatusGc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14473 NCBI Gene Model | MGI Sequence Detail 40388 C57BL/6J ±  kb
transcript NM_008096 RefSeq | MGI Sequence Detail 1812 C57BL/6 
polypeptide P21614 UniProt | EBI | MGI Sequence Detail 476 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(358 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000264 ALB/AFP/VDB
InterPro IPR020857 Serum albumin, conserved site
InterPro IPR020858 Serum albumin-like
InterPro IPR014760 Serum albumin, N-terminal
InterPro IPR000213 Vitamin D-binding protein
InterPro IPR015247 Vitamin D binding protein, domain III
Protein Ontology PR:000007883 vitamin D-binding protein
Graphical View of Protein Domain Structure
References (Earliest) J:20200 Daiger SP, et al., Group-specific component (Gc) proteins bind vitamin D and 25-hydroxyvitamin D. Proc Natl Acad Sci U S A. 1975 Jun;72(6):2076-80
(Latest) J:204824 Trujillo G, et al., Neutrophil recruitment to the lung in both C5a- and CXCL1-induced alveolitis is impaired in vitamin D-binding protein-deficient mice. J Immunol. 2013 Jul 15;191(2):848-56
All references(43)
Other
accession IDs
MGD-MRK-10014

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory