Gc
Gene Detail

Symbol Name ID

Gc group specific component MGI:95669

Synonyms

DBP, vitamin D binding protein

Feature Type

protein coding gene

Genetic Map

Chromosome 5

44.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr5:89417511-89457898 bp, - strand From NCBI annotation of GRCm38   40388 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:486  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: vitamin D-binding protein
Gene Tree: Gc

Human homologs

Human Homolog		GC, group-specific component (vitamin D binding protein)
NCBI Gene ID		2638
neXtProt AC		NX_P02774
Human Synonyms		DBP, DBP/GC, GRD3, VDBG, VDBP
Human Chr (Location)		4q12-q13; chr4:72607410-72671237 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GC

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for disruption of this gene show an essentially normal phenotype. However, they have an increased sensitivity to vitamin D deficiency in the diet.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	transport, vitamin D metabolic process, ...
Component	axon, cytosol, ...
Function	actin binding, vitamin D binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (3)    Tissues (3)    Images (1)
Theiler Stages: 17, 20, 22

Assay Type	Results
RNA in situ	1
RT-PCR	2

cDNA source data(189)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(195) Genomic(2) cDNA(191) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000035540 (Evidence)
Entrez Gene	14473 (Evidence)
UniGene	196595
DFCI	TC1574034, TC1767196
DoTS	DT.97362586
NIA Mouse Gene Index	U026376
Consensus CDS Project	CCDS19407.1
International Mouse Knockout Project Status	Gc

Sequences

Length	Strain/Species
genomic	14473	NCBI Gene Model | MGI Sequence Detail	40388	C57BL/6J
transcript	NM_008096	RefSeq | MGI Sequence Detail	1812	C57BL/6
polypeptide	P21614	UniProt | EBI | MGI Sequence Detail	476	Not Applicable

All sequences(20) RefSeq(2) UniProt(1)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(318 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000264	Serum albumin
InterPro	IPR020857	Serum albumin, conserved site
InterPro	IPR020858	Serum albumin-like
InterPro	IPR014760	Serum albumin, N-terminal
InterPro	IPR000213	Vitamin D-binding protein
InterPro	IPR015247	Vitamin D binding protein, domain III
Protein Ontology	PR:000007883	vitamin D-binding protein

Graphical View of Protein Domain Structure

References

(Earliest) J:20200 Daiger SP, et al., Group-specific component (Gc) proteins bind vitamin D and 25-hydroxyvitamin D. Proc Natl Acad Sci U S A. 1975 Jun;72(6):2076-80
(Latest) J:168170 Inoue T, et al., APOA-1 is a Novel Marker of Erythroid Cell Maturation from Hematopoietic Stem Cells in Mice and Humans. Stem Cell Rev. 2011 Mar;7(1):43-52
All references(40)

Other accession IDs

MGD-MRK-10014