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Gata1
Gene Detail
Symbol

Name
ID
Gata1
GATA binding protein 1
MGI:95661
STS
Synonyms
Gata-1, Gf-1
Feature Type
protein coding gene
Genetic Map
Chromosome X
3.59 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
ChrX:7959260-7978071 bp, - strand
From VEGA annotation of GRCm38

  18812 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1549  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor, GATA-1/2/3 types
Gene Tree: Gata1

Human
homologs
Human Homolog GATA1, GATA binding protein 1 (globin transcription factor 1)
NCBI Gene ID 2623
neXtProt AC  NX_P15976
Human Synonyms  ERYF1, GATA-1, GF1, GF-1, NFE1, NF-E1, XLANP, XLTDA, XLTT
Human Chr (Location)  Xp11.23; chrX:48786574-48794311 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human GATA1
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(15)
Incidental mutations (data from APF )
 
Mutation of this locus affects hematopoiesis. Most hemizygous mutant males mice die at mid-gestation and exhibit blocked erythroid development. Female null and hypomorphic mutants survive birth but exhibit varying degrees of anemia and impaired hematopoiesis.
 
Human Diseases Modeled Using Mouse Gata1 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(4)
Interactions
Gata1 interacts with 85 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (86 annotations)
Process basophil differentiation, cell-cell signaling, ...
Component nucleus, transcriptional repressor complex, ...
Function C2H2 zinc finger domain binding, chromatin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (99 records)
Data Summary: Results (375)    Tissues (222)    Images (63)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 186
Northern blot 19
Western blot 3
RT-PCR 165
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) Genomic(5) cDNA(30) Primer pair(17) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000018011 (Evidence)
Ensembl Gene ModelENSMUSG00000031162 (Evidence)
Entrez Gene14460 (Evidence)
UniGene335973
DFCITC1583912
DoTSDT.531152, DT.94205390
NIA Mouse Gene IndexU039236
PDB1GNF, 1Y0J, 2L5E, 2L6Y, 2L6Z, 3VEK, 3VD6
Consensus CDS ProjectCCDS29981.1
International Mouse Knockout Project StatusGata1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018011 VEGA Gene Model | MGI Sequence Detail 18812 C57BL/6J ±  kb
transcript OTTMUST00000043496 VEGA | MGI Sequence Detail 1902 Not Applicable 
polypeptide OTTMUSP00000019548 VEGA | MGI Sequence Detail 413 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(9) : SNPs within 2kb(105 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016374 Transcription factor, GATA-1/2/3
InterPro IPR000679 Zinc finger, GATA-type
InterPro IPR013088 Zinc finger, NHR/GATA-type
Protein Ontology PR:000007857 erythroid transcription factor
References
(Earliest) J:9808 Tsai SF, et al., Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature. 1989 Jun 8;339(6224):446-51
(Latest) J:214840 Chu DK, et al., Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo. J Exp Med. 2014 Jul 28;211(8):1657-72
All references(315)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-10002, MGD-MRK-10054, MGD-MRK-9998

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory