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Gata1
Gene Detail
 Symbol
Name
ID
Gata1
GATA binding protein 1
MGI:95661
STS DXCch5
Synonyms Gata-1, Gf-1
Feature Type protein coding gene
Genetic Map
Chromosome X
3.59 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
ChrX:7959260-7978071 bp, - strand
From VEGA annotation of GRCm38

  18812 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1549  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: transcription factor, GATA-1/2/3 types
Gene Tree: Gata1

Human
homologs
Human Homolog GATA1, GATA binding protein 1 (globin transcription factor 1)
NCBI Gene ID 2623
neXtProt AC  NX_P15976
Human Synonyms  ERYF1, GATA-1, GF1, GF-1, NFE1, NF-E1, XLANP, XLTDA, XLTT
Human Chr (Location)  Xp11.23; chrX:48786574-48794311 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human GATA1
Alleles
and
phenotypes
All alleles(17) : Targeted(15) Gene trapped(1) Chemically induced(1)
 
Mutation of this locus affects hematopoiesis. Most hemizygous mutant males mice die at mid-gestation and exhibit blocked erythroid development. Female null and hypomorphic mutants survive birth but exhibit varying degrees of anemia and impaired hematopoiesis.
 
Human Diseases Modeled Using Mouse Gata1 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(4)
Gene Ontology
(GO)
classifications
All GO classifications: (86 annotations)
Process cell-cell signaling, cell development, ...
Component nucleus, transcriptional repressor complex, ...
Function C2H2 zinc finger domain binding, chromatin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (94 records)
Data Summary: Results (384)    Tissues (226)    Images (62)
Theiler Stages: 2, 3, 4, 5, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 186
Northern blot 19
Western blot 4
RT-PCR 173
cDNA source data(28)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(55) Genomic(5) cDNA(30) Primer pair(17) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000018011 (Evidence)
Ensembl Gene ModelENSMUSG00000031162 (Evidence)
Entrez Gene14460 (Evidence)
UniGene335973
DFCITC1583912
DoTSDT.531152, DT.94205390
NIA Mouse Gene IndexU039236
PDB1GNF, 1Y0J, 2L5E, 2L6Y, 2L6Z, 3VEK, 3VD6
Consensus CDS ProjectCCDS29981.1
International Mouse Knockout Project StatusGata1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018011 VEGA Gene Model | MGI Sequence Detail 18812 C57BL/6J ±  kb
transcript OTTMUST00000043496 VEGA | MGI Sequence Detail 1902 Not Applicable 
polypeptide OTTMUSP00000019548 VEGA | MGI Sequence Detail 413 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(3)
Polymorphisms RFLP(9) : SNPs within 2kb(105 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016374 Transcription factor, GATA-1/2/3
InterPro IPR000679 Zinc finger, GATA-type
InterPro IPR013088 Zinc finger, NHR/GATA-type
Protein Ontology PR:000007857 erythroid transcription factor
References (Earliest) J:9808 Tsai SF, et al., Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature. 1989 Jun 8;339(6224):446-51
(Latest) J:206262 Barin JG, et al., Fatal eosinophilic myocarditis develops in the absence of IFN-gamma and IL-17A. J Immunol. 2013 Oct 15;191(8):4038-47
All references(301)
Other
accession IDs
MGD-MRK-10002, MGD-MRK-10054, MGD-MRK-9998

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory