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Gata1
Gene Detail
Symbol

Name
ID
Gata1
GATA binding protein 1
MGI:95661
STS
Synonyms
Gata-1, Gf-1
Feature Type
protein coding gene
Genetic Map
Chromosome X
3.59 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
ChrX:7959260-7978071 bp, - strand
From VEGA annotation of GRCm38

  18812 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1549  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GATA1
Protein SuperFamily: transcription factor, GATA-1/2/3 types
Gene Tree: Gata1

Human
homologs
GATA1, GATA binding protein 1 (globin transcription factor 1)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2623
neXtProt AC: NX_P15976

Human Synonyms: ERYF1, GATA-1, GF1, GF-1, NFE1, NF-E1, XLANP, XLTDA, XLTT

Human Chr (Location): Xp11.23; chrX:48786560-48794311 (+)  GRCh38.p2

Disease Associations: (4) Diseases Associated with Human GATA1

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(15) Transgenic(1)
Incidental mutations (data from APF )
 
Mutation of this locus affects hematopoiesis. Most hemizygous mutant males mice die at mid-gestation and exhibit blocked erythroid development. Female null and hypomorphic mutants survive birth but exhibit varying degrees of anemia and impaired hematopoiesis.
 
Human Diseases Modeled in Mice Using Gata1 (1)    Mutations Annotated to Human Diseases (3)    Phenotype Images(4)
Interactions
Gata1 interacts with 85 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (92 annotations)
Process basophil differentiation, cell-cell signaling, ...
Component nucleus, transcriptional repressor complex, ...
Function C2H2 zinc finger domain binding, chromatin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (102 records)
Data Summary: Results (375)    Tissues (222)    Images (63)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 186
Northern blot 19
Western blot 3
RT-PCR 165
cDNA source data(28)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100497467 ; ZFIN gata1a    NEW 
Molecular
reagents
All nucleic(55) Genomic(5) cDNA(30) Primer pair(17) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000018011 (Evidence)
Ensembl Gene Model ENSMUSG00000031162 (Evidence)
Entrez Gene 14460 (Evidence)
UniGene 335973
DFCI TC1583912
DoTS DT.531152, DT.94205390
NIA Mouse Gene Index U039236
PDB 1GNF, 1Y0J, 2L5E, 2L6Y, 2L6Z, 3VEK, 3VD6
Consensus CDS Project CCDS29981.1
International Mouse Phenotyping Consortium Status Gata1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018011 VEGA Gene Model | MGI Sequence Detail 18812 C57BL/6J ±  kb
transcript OTTMUST00000043496 VEGA | MGI Sequence Detail 1902 Not Applicable 
polypeptide OTTMUSP00000019548 VEGA | MGI Sequence Detail 413 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(9) : SNPs within 2kb(105 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000679 Zinc finger, GATA-type
InterPro IPR013088 Zinc finger, NHR/GATA-type
Protein Ontology PR:000007857 erythroid transcription factor
References
(Earliest) J:9808 Tsai SF, et al., Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature. 1989 Jun 8;339(6224):446-51
(Latest) J:220996 La Sala G, et al., Modulation of Dhh signaling and altered Sertoli cell function in mice lacking the GPR37-prosaposin receptor. FASEB J. 2015 May;29(5):2059-69
All references(323)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-10002, MGD-MRK-10054, MGD-MRK-9998

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory