Gata1
Gene Detail

Symbol Name ID

Gata1 GATA binding protein 1 MGI:95661

STS

DXCch5

Synonyms

Gata-1, Gf-1

Feature Type

protein coding gene

Genetic Map

Chromosome X

3.59 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(19)

Sequence Map

ChrX:7959260-7978071 bp, - strand From VEGA annotation of GRCm38   18812 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1549  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: transcription factor, GATA-1/2/3 types
Gene Tree: Gata1

Human homologs

Human Homolog		GATA1, GATA binding protein 1 (globin transcription factor 1)
NCBI Gene ID		2623
neXtProt AC		NX_P15976
Human Synonyms		ERYF1, GATA-1, GF1, GF-1, NFE1, XLANP, XLTDA, XLTT
Human Chr (Location)		Xp11.23; chrX:48644982-48652718 (+)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human GATA1

Alleles and phenotypes

All alleles(15) : Targeted(13) Gene trapped(1) Chemically induced(1)
 

Mutation of this locus affects hematopoiesis. Most hemizygous mutant males mice die at mid-gestation and exhibit blocked erythroid development. Female null and hypomorphic mutants survive birth but exhibit varying degrees of anemia and impaired hematopoiesis.

 
Alleles Annotated to Human Diseases(1)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (84 annotations)

Process	cell-cell signaling, cell development, ...
Component	nuclear membrane, nucleolus, ...
Function	C2H2 zinc finger domain binding, chromatin binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (90 records)
Data Summary: Results (383)    Tissues (225)    Images (62)
Theiler Stages: 2, 3, 4, 5, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	186
Northern blot	19
Western blot	3
RT-PCR	173

cDNA source data(28)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(55) Genomic(5) cDNA(30) Primer pair(17) Other(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000018011 (Evidence)
Ensembl Gene Model	ENSMUSG00000031162 (Evidence)
Entrez Gene	14460 (Evidence)
UniGene	335973
DFCI	TC1583912
DoTS	DT.531152, DT.94205390
NIA Mouse Gene Index	U039236
PDB	1GNF, 1Y0J, 2L5E, 2L6Y, 2L6Z
Consensus CDS Project	CCDS29981.1
International Mouse Knockout Project Status	Gata1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018011	VEGA Gene Model | MGI Sequence Detail	18812	C57BL/6J
transcript	OTTMUST00000043496	VEGA | MGI Sequence Detail	1902	Not Applicable
polypeptide	OTTMUSP00000019548	VEGA | MGI Sequence Detail	413	Not Applicable

All sequences(30) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(9) : SNPs(42 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016374	Transcription factor, GATA-1/2/3
InterPro	IPR000679	Zinc finger, GATA-type
InterPro	IPR013088	Zinc finger, NHR/GATA-type
Protein Ontology	PR:000007857	erythroid transcription factor

References

(Earliest) J:9808 Tsai SF, et al., Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature. 1989 Jun 8;339(6224):446-51
(Latest) J:194035 Kan A, et al., c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
All references(284)

Other accession IDs

MGD-MRK-10002, MGD-MRK-10054, MGD-MRK-9998