About   Help   FAQ
Tg(Gata1*V205G)1Mym
Transgene Detail
Summary
Symbol: Tg(Gata1*V205G)1Mym
Name: transgene insertion 1, Masayuki Yamamoto
MGI ID: MGI:5295641
Synonyms: V205G
Transgene: Tg(Gata1*V205G)1Mym  Location: unknown  
Alliance: Tg(Gata1*V205G)1Mym page
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Gata1*V205G)1Mym expresses 1 gene
 
Mutation detailsThis transgene consists of the murine Gata1 cDNA with a V205G (GTG to GGG) mutation under the control of the Gata1 genomic locus spanning 3.9 kb 5' of the hematopoietic IE exon to the second exon (GATA-1 HRD) which recapitulates endogenous Gata1 gene expression. The valine 205 to glycine substitution has been shown to reduce Zfpm1 (Fog-1) association. Five lines were made. This line is a high-expressing line. (J:89054)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:89054 Shimizu R, et al., Transgenic rescue of GATA-1-deficient mice with GATA-1 lacking a FOG-1 association site phenocopies patients with X-linked thrombocytopenia. Blood. 2004 Apr 1;103(7):2560-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/01/2024
MGI 6.24
The Jackson Laboratory