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Gad2
Gene Detail
 Symbol
Name
ID
Gad2
glutamic acid decarboxylase 2
MGI:95634
Synonyms 6330404F12Rik, Gad-2, GAD65, GAD(65)
Feature Type protein coding gene
Genetic Map
Chromosome 2
15.15 cM, cytoband A-B
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr2:22622205-22693874 bp, + strand
From VEGA annotation of GRCm38

  71670 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20223  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glutamate decarboxylase
Gene Tree: Gad2

Human
homologs
Human Homolog GAD2, glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
NCBI Gene ID 2572
neXtProt AC  NX_Q05329
Human Synonyms  GAD65
Human Chr (Location)  10p11.23; chr10:26216307-26304562 (+)  GRCh38
Alleles
and
phenotypes
All alleles(10) : Targeted(10)
 
Homozygotes for targeted null mutations exhibit spontaneous (frequently fatal) seizures, increased anxiety-like behavior, and reduced intermale aggression. Heterozygotes show reduced aggressiveness.
 
Human Diseases Modeled Using Mouse Gad2 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process carboxylic acid metabolic process, glutamate decarboxylation to succinate, ...
Component anchored component of membrane, axon, ...
Function carboxy-lyase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (74 records)
Data Summary: Results (701)    Tissues (233)    Images (92)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 25
RNA in situ 584
Western blot 8
RT-PCR 78
RNase protection 6
cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(18) Primer pair(6) Other(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000011505 (Evidence)
Ensembl Gene ModelENSMUSG00000026787 (Evidence)
Entrez Gene14417 (Evidence)
DFCITC1584235, TC1607553
DoTSDT.40156423, DT.91335306, DT.91336413, DT.97376990
NIA Mouse Gene IndexU001449
EC4.1.1.15
Consensus CDS ProjectCCDS15724.1
International Mouse Knockout Project StatusGad2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011505 VEGA Gene Model | MGI Sequence Detail 71670 C57BL/6J ±  kb
transcript OTTMUST00000026891 VEGA | MGI Sequence Detail 5744 Not Applicable 
polypeptide OTTMUSP00000012268 VEGA | MGI Sequence Detail 585 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(634 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021115 Pyridoxal-phosphate binding site
InterPro IPR002129 Pyridoxal phosphate-dependent decarboxylase
InterPro IPR015424 Pyridoxal phosphate-dependent transferase
InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Protein Ontology PR:000007786 glutamate decarboxylase 2
References (Earliest) J:16802 Maxson SC, et al., Electroencephalographic correlates of the audiogenic seizure response of inbred mice. Physiol Behav. 1976 May;16(5):623-9
(Latest) J:207152 Tomiyama K, et al., Phenotypic characterization of orofacial movement topography in mutants with disruption of amino acid mechanisms: glutamate N2A/B/D [GluRepsilon1/2/4] subtypes and the GABA synthesizing enzyme GAD65. Neuroscience. 2013 Oct 10;250:743-54
All references(177)
Other
accession IDs
MGD-MRK-9955, MGD-MRK-9959, MGI:1918008

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory