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Gad2 Gene Detail
Summary
  • Symbol
    Gad2
  • Name
    glutamic acid decarboxylase 2
  • Synonyms
    6330404F12Rik, Gad-2, GAD65, GAD(65)
  • Feature Type
    protein coding gene
  • IDs
    MGI:95634
    NCBI Gene: 14417
  • Gene Overview
    MyGene.info: GAD2
Location & Maps
more
  • Sequence Map
    Chr2:22622205-22693874 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      71670 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 15.15 cM, cytoband A-B
  • Mapping Data
    13 experiments
Homology
more
  • Human Ortholog
    GAD2, glutamate decarboxylase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GAD2, glutamate decarboxylase 2
    Orthology source: HomoloGene
  • Synonyms
    GAD65
  • Links
    NCBI Gene ID: 2572
    neXtProt AC: NX_Q05329

  • Chr Location
    10p11.23; chr10:26216307-26304562 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Gad2 mouse models

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100 View 1 model
Stiff-Person Syndrome; SPS   OMIM: 184850
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 7 alleles in 8 genetic backgrounds
    22 phenotypes from multigenic genotypes
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit spontaneous (frequently fatal) seizures, increased anxiety-like behavior, and reduced intermale aggression. Heterozygotes show reduced aggressiveness.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011505 VEGA Gene Model | MGI Sequence Detail 71670 C57BL/6J ±  kb
transcript OTTMUST00000026891 VEGA | MGI Sequence Detail 5744 Not Applicable  
polypeptide OTTMUSP00000012268 VEGA | MGI Sequence Detail 585 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    633 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007786 glutamate decarboxylase 2
  • EC
  • InterPro Domains
    IPR021115 Pyridoxal-phosphate binding site
    IPR002129 Pyridoxal phosphate-dependent decarboxylase
    IPR015424 Pyridoxal phosphate-dependent transferase
    IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
    IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Molecular
Reagents
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  • All nucleic 28
    Genomic 1
    cDNA 19
    Primer pair 6
    Other 2

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-9955, MGD-MRK-9959, MGI:1918008
References
more
  • Summaries
    All 223
    Developmental Gene Expression 90
    Diseases 2
    Gene Ontology 6
    Phenotypes 77
  • Earliest
    J:16802 Maxson SC, et al., Electroencephalographic correlates of the audiogenic seizure response of inbred mice. Physiol Behav. 1976 May;16(5):623-9
  • Latest
    J:229663 Mardinly AR, et al., Sensory experience regulates cortical inhibition by inducing IGF1 in VIP neurons. Nature. 2016 Mar 17;531(7594):371-5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory