Gad2
Gene Detail

Symbol Name ID

Gad2 glutamic acid decarboxylase 2 MGI:95634

Synonyms

6330404F12Rik, Gad-2, GAD65, GAD(65)

Feature Type

protein coding gene

Genetic Map

Chromosome 2

15.15 cM, cytoband A-B
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr2:22622205-22693874 bp, + strand From VEGA annotation of GRCm38   71670 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20223  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glutamate decarboxylase
Gene Tree: Gad2

Human homologs

Human Homolog		GAD2, glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
NCBI Gene ID		2572
neXtProt AC		NX_Q05329
Human Synonyms		GAD65
Human Chr (Location)		10p11.23; chr10:26505236-26593491 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(8)
 

Homozygotes for targeted null mutations exhibit spontaneous (frequently fatal) seizures, increased anxiety-like behavior, and reduced intermale aggression. Heterozygotes show reduced aggressiveness.

 
Human Diseases Modeled Using Mouse Gad2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	carboxylic acid metabolic process, glutamate decarboxylation to succinate, ...
Component	anchored to membrane, axon, ...
Function	carboxy-lyase activity, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (70 records)
Data Summary: Results (701)    Tissues (233)    Images (92)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	25
RNA in situ	584
Western blot	8
RT-PCR	78
RNase protection	6

cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(1) cDNA(18) Primer pair(6) Other(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000011505 (Evidence)
Ensembl Gene Model	ENSMUSG00000026787 (Evidence)
Entrez Gene	14417 (Evidence)
DFCI	TC1584235, TC1607553
DoTS	DT.40156423, DT.91335306, DT.91336413, DT.97376990
NIA Mouse Gene Index	U001449
EC	4.1.1.15
Consensus CDS Project	CCDS15724.1
International Mouse Knockout Project Status	Gad2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011505	VEGA Gene Model | MGI Sequence Detail	71670	C57BL/6J
transcript	OTTMUST00000026891	VEGA | MGI Sequence Detail	5744	Not Applicable
polypeptide	OTTMUSP00000012268	VEGA | MGI Sequence Detail	585	Not Applicable

All sequences(37) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(463 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR021115	Pyridoxal-phosphate binding site
InterPro	IPR002129	Pyridoxal phosphate-dependent decarboxylase
InterPro	IPR015424	Pyridoxal phosphate-dependent transferase
InterPro	IPR015421	Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro	IPR015422	Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Protein Ontology	PR:000007786	glutamate decarboxylase 2

References

(Earliest) J:16802 Maxson SC, et al., Electroencephalographic correlates of the audiogenic seizure response of inbred mice. Physiol Behav. 1976 May;16(5):623-9
(Latest) J:194213 Brown MT, et al., Ventral tegmental area GABA projections pause accumbal cholinergic interneurons to enhance associative learning. Nature. 2012 Dec 20;492(7429):452-6
All references(167)

Other accession IDs

MGD-MRK-9955, MGD-MRK-9959, MGI:1918008