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Gad2
Gene Detail
Symbol

Name
ID
Gad2
glutamic acid decarboxylase 2
MGI:95634
Synonyms
6330404F12Rik, Gad-2, GAD65, GAD(65)
Feature Type
protein coding gene
Genetic Map
Chromosome 2
15.15 cM, cytoband A-B
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr2:22622205-22693874 bp, + strand
From VEGA annotation of GRCm38

  71670 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20223  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GAD2
Protein SuperFamily: glutamate decarboxylase
Gene Tree: Gad2

Human
homologs
GAD2, glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2572
neXtProt AC: NX_Q05329

Human Synonyms: GAD65

Human Chr (Location): 10p11.23; chr10:26216307-26304562 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(10) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit spontaneous (frequently fatal) seizures, increased anxiety-like behavior, and reduced intermale aggression. Heterozygotes show reduced aggressiveness.
 
Human Diseases Modeled in Mice Using Gad2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Gad2 interacts with 418 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process carboxylic acid metabolic process, glutamate decarboxylation to succinate, ...
Component anchored component of membrane, axon, ...
Function carboxy-lyase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (85 records)
Data Summary: Results (721)    Tissues (241)    Images (119)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 40
RNA in situ 589
Western blot 8
RT-PCR 78
RNase protection 6
cDNA source data(15)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA GAD2 ZFIN gad2    NEW 
Molecular
reagents
All nucleic(28) Genomic(1) cDNA(19) Primer pair(6) Other(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000011505 (Evidence)
Ensembl Gene Model ENSMUSG00000026787 (Evidence)
Entrez Gene 14417 (Evidence)
DFCI TC1584235, TC1607553
DoTS DT.40156423, DT.91335306, DT.91336413, DT.97376990
NIA Mouse Gene Index U001449
EC 4.1.1.15
Consensus CDS Project CCDS15724.1
International Mouse Phenotyping Consortium Status Gad2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011505 VEGA Gene Model | MGI Sequence Detail 71670 C57BL/6J ±  kb
transcript OTTMUST00000026891 VEGA | MGI Sequence Detail 5744 Not Applicable 
polypeptide OTTMUSP00000012268 VEGA | MGI Sequence Detail 585 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(634 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021115 Pyridoxal-phosphate binding site
InterPro IPR002129 Pyridoxal phosphate-dependent decarboxylase
InterPro IPR015424 Pyridoxal phosphate-dependent transferase
InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Protein Ontology PR:000007786 glutamate decarboxylase 2
References
(Earliest) J:16802 Maxson SC, et al., Electroencephalographic correlates of the audiogenic seizure response of inbred mice. Physiol Behav. 1976 May;16(5):623-9
(Latest) J:222938 Ankri L, et al., A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity. Elife. 2015;4
All references(210)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-9955, MGD-MRK-9959, MGI:1918008

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory