Fgfr3
Gene Detail

Symbol Name ID

Fgfr3 fibroblast growth factor receptor 3 MGI:95524

Synonyms

Fgfr-3, HBGFR, sam3

Feature Type

protein coding gene

Genetic Map

Chromosome 5

17.83 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr5:33721724-33737067 bp, + strand From VEGA annotation of GRCm38   15344 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55437  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: fibroblast growth factor receptor
Gene Tree: Fgfr3

Human homologs

Human Homolog		FGFR3, fibroblast growth factor receptor 3
NCBI Gene ID		2261
neXtProt AC		NX_P22607
Human Synonyms		ACH, CD333, CEK2, HSFGFR3EX, JTK4
Human Chr (Location)		4p16.3; chr4:1795039-1810599 (+)  GRCh37.p10
Disease Associations		(13) Diseases Associated with Human FGFR3

Alleles and phenotypes

All alleles(26) : Targeted(25) Spontaneous(1)
 

Mutant alleles generally cause skeletal deformities, with some causing decreased body size, premature death, or hearing loss due to developmental defects of the ear.

 
Human Diseases Modeled Using Mouse Fgfr3 (5)    Alleles Annotated to Human Diseases(9)    Phenotype Images(12)

Gene Ontology (GO) classifications

All GO classifications: (94 annotations)

Process	alveolar secondary septum development, apoptotic process, ...
Component	cell surface, cytoplasm, ...
Function	ATP binding, fibroblast growth factor-activated receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (147 records)
Data Summary: Results (390)    Tissues (238)    Images (101)
Theiler Stages: 2, 3, 4, 10, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	266
Northern blot	7
RT-PCR	107
RNase protection	8

cDNA source data(25)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(53) Genomic(4) cDNA(28) Primer pair(19) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000021524 (Evidence)
Ensembl Gene Model	ENSMUSG00000054252 (Evidence)
Entrez Gene	14184 (Evidence)
DFCI	TC1576655, TC1596578
DoTS	DT.101351715, DT.101390235, DT.488578, DT.97413536
NIA Mouse Gene Index	U042629
EC	2.7.10.1
Consensus CDS Project	CCDS51464.1, CCDS51465.1, CCDS51466.1, CCDS57335.1
International Mouse Knockout Project Status	Fgfr3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021524	VEGA Gene Model | MGI Sequence Detail	15344	C57BL/6J
transcript	OTTMUST00000051048	VEGA | MGI Sequence Detail	4221	Not Applicable
polypeptide	OTTMUSP00000023967	VEGA | MGI Sequence Detail	801	Not Applicable

All sequences(92) RefSeq(10) UniProt(10)

Polymorphisms

All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs(45 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR016248	Tyrosine-protein kinase, fibroblast growth factor receptor
Protein Ontology	PR:000001450	fibroblast growth factor receptor 3

References

(Earliest) J:30010 Avivi A, et al., Flg-2, a new member of the family of fibroblast growth factor receptors [published erratum appears in Oncogene 1992 Apr;7(4):823]. Oncogene. 1991 Jun;6(6):1089-92
(Latest) J:192712 Meadows SM, et al., Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels. Circ Res. 2012 Jan 6;110(1):34-46
All references(277)

Other accession IDs

MGD-MRK-9778, MGD-MRK-9783