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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fgfr3
fibroblast growth factor receptor 3
MGI:95524
71 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Cdkn1atm1Led/Cdkn1atm1Led
Fgfr3tm1Cxd/Fgfr3tm1Cxd
involves: 129S6/SvEvTac * NIH Black Swiss 		abnormal long bone epiphyseal plate morphology J:52438
abnormal skeleton morphology J:52438
disproportionate dwarf J:52438
Ctnnb1tm1Mmt/Ctnnb1+
Fgfr3tm4Cxd/Fgfr3+
Tg(Upk2-cre)6Xrw/0
involves: 129S6/SvEvTac * 129X1/SvJ * FVB/N 		abnormal urinary bladder urothelium morphology J:174242
increased lung tumor incidence J:174242
normal neoplasm J:174242
premature death J:174242
Fgf8tm1Mrc/Fgf8+
Fgf9tm1Dor/Fgf9+
Fgfr3tm1.1Aomw/Fgfr3+
involves: 129 * BALB/c * C57BL/6 		impaired hearing J:143356
increased or absent threshold for auditory brainstem response J:143356
Fgf8tm1Mrc/Fgf8+
Fgfr3tm1.1Aomw/Fgfr3+
involves: 129 * BALB/c * C57BL/6 		impaired hearing J:143356
increased or absent threshold for auditory brainstem response J:143356
Fgf9tm1Dor/Fgf9+
Fgfr3tm1.1Aomw/Fgfr3+
involves: 129 * BALB/c * C57BL/6 		impaired hearing J:143356
increased or absent threshold for auditory brainstem response J:143356
Fgfr2tm1Dor/Fgfr2+
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Frs3tm1Jheb/Frs3tm1Jheb
involves: 129 		normal cellular phenotype J:242687
normal nervous system phenotype J:242687
Fgfr2tm1Dor/Fgfr2tm1Dor
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm6.1Jrt/Fgfr1tm1Jpa
involves: 129 		normal nervous system phenotype J:242687
Fgfr2tm1Dor/Fgfr2tm1Dor
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Frs3tm1Jheb/Frs3tm1Jheb
involves: 129 		absent telencephalon J:242687
Fgfr2tm1Dor/Fgfr2tm1Dor
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm3.1Sor/Fgfr1tm1Jpa
Frs3tm1Jheb/Frs3tm1Jheb
involves: 129 		absent telencephalon J:242687
normal cellular phenotype J:242687
increased cell death J:242687
Fgfr3tm1.1(FGFR3*)Ytc/Fgfr3+
involves: 129 		abnormal bone ossification J:287271
abnormal cranium morphology J:287271
abnormal long bone diaphysis morphology J:287271
abnormal long bone epiphyseal plate morphology J:287271
abnormal long bone epiphyseal plate proliferative zone J:287271
abnormal long bone hypertrophic chondrocyte zone J:287271
abnormal long bone metaphysis morphology J:287271
abnormal neurocranium morphology J:287271
abnormal thoracic cage morphology J:287271
abnormal vertebral column morphology J:287271
absent jugum limitans J:287271
bowed femur J:287271
decreased body length J:287271
decreased body weight J:287271
decreased bone mineral density J:287271
decreased bone trabecula number J:287271
decreased bone volume J:287271
decreased chondrocyte proliferation J:287271
decreased long bone epiphyseal plate size J:287271
decreased osteoblast cell number J:287271
decreased osteoclast cell number J:287271
decreased trabecular bone thickness J:287271
decreased trabecular bone volume J:287271
decreased width of hypertrophic chondrocyte zone J:287271
delayed bone ossification J:287271
disproportionate dwarf J:287271
domed cranium J:287271
increased bone trabecular spacing J:287271
increased diameter of femur J:287271
kyphosis J:287271
midface hypoplasia J:287271
misaligned incisors J:287271
premature craniofacial suture closure J:287271
premature death J:287271
premature metopic suture closure J:287271
rhizomelic limb J:287271
round head J:287271
short femur J:287271
short snout J:287271
Fgfr3tm1.1(FGFR3*)Ytc/Fgfr3tm1.1(FGFR3*)Ytc
involves: 129 		abnormal bone ossification J:287271
abnormal cranium morphology J:287271
abnormal long bone diaphysis morphology J:287271
abnormal long bone epiphyseal plate morphology J:287271
abnormal long bone epiphyseal plate proliferative zone J:287271
abnormal long bone hypertrophic chondrocyte zone J:287271
abnormal long bone metaphysis morphology J:287271
abnormal neurocranium morphology J:287271
abnormal thoracic cage morphology J:287271
abnormal vertebral column morphology J:287271
absent jugum limitans J:287271
bowed femur J:287271
decreased body length J:287271
decreased body weight J:287271
decreased bone mineral density J:287271
decreased bone trabecula number J:287271
decreased bone volume J:287271
decreased chondrocyte proliferation J:287271
decreased long bone epiphyseal plate size J:287271
decreased osteoblast cell number J:287271
decreased osteoclast cell number J:287271
decreased survivor rate J:287271
decreased trabecular bone thickness J:287271
decreased trabecular bone volume J:287271
decreased width of hypertrophic chondrocyte zone J:287271
delayed bone ossification J:287271
disproportionate dwarf J:287271
domed cranium J:287271
increased bone trabecular spacing J:287271
increased diameter of femur J:287271
kyphosis J:287271
midface hypoplasia J:287271
misaligned incisors J:287271
neonatal lethality, incomplete penetrance J:287271
postnatal lethality, incomplete penetrance J:287271
premature craniofacial suture closure J:287271
premature death J:287271
premature metopic suture closure J:287271
rhizomelic limb J:287271
round head J:287271
short femur J:287271
short snout J:287271
Fgfr3tm1Aomw/Fgfr3+
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:144356
Fgfr3tm1Aomw/Fgfr3tm1Aomw
involves: 129P2/OlaHsd 		abnormal craniofacial morphology J:144356
Fgfr3tm1Dor/Fgfr3tm1Dor
Pthlhtm1Fbe/Pthlhtm1Fbe
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ 		abnormal axial skeleton morphology J:109505
abnormal long bone epiphyseal plate morphology J:109505
abnormal long bone hypertrophic chondrocyte zone J:109505
decreased long bone epiphyseal plate size J:109505
domed cranium J:109505
increased width of hypertrophic chondrocyte zone J:109505
neonatal lethality, complete penetrance J:109505
short femur J:109505
short humerus J:109505
short limbs J:109505
short radius J:109505
short ulna J:109505
Fgfr3tm1Dor/Fgfr3tm1Dor
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-Fgf9,-EGFP)#Dor/0
involves: 129S6/SvEvTac * C57BL/6J * FVB 		decreased organ/body region tumor incidence J:204282
Fgfr3tm1Iwa/Fgfr3+
Tg(Upk2-cre)6Xrw/0
involves: 129S6/SvEvTac * FVB/N 		normal neoplasm J:174242
Fgfr3tm1Led/Fgfr3tm1Led
Fgfr4tm1Cxd/Fgfr4tm1Cxd
involves: 129S6/SvEvTac * Black Swiss 		abnormal pulmonary elastic fiber morphology J:50677
absent pulmonary alveoli J:50677
decreased body size J:50677
dehydration J:50677
emphysema J:50677
impaired lung alveolus development J:50677
infertility J:50677
postnatal growth retardation J:50677
premature death J:50677
Fgfr3tm1Led/Fgfr3tm1Led
Glg1tm1Brle/Glg1tm1Brle
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J 		decreased body size J:163721
decreased long bone epiphyseal plate size J:163721
Fgfr3tm4Cxd/Fgfr3+
Krastm4Tyj/Kras+
Tg(Upk2-cre)6Xrw/0
involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N 		increased skin papilloma incidence J:174242
normal neoplasm J:174242
premature death J:174242
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory