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Erg Gene Detail
Summary
  • Symbol
    Erg
  • Name
    ETS transcription factor
  • Synonyms
    D030036I24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:95415
    NCBI Gene: 13876
  • Gene Overview
    MyGene.info: ERG
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:95359169-95586593 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      227425 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 56.04 cM
  • Mapping Data
    13 experiments
Homology
more
  • Human Ortholog
    ERG, ETS transcription factor ERG
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ERG, ETS transcription factor ERG
    Orthology source: HGNC, HomoloGene
  • Synonyms
    erg-3, p55
  • Links
    NCBI Gene ID: 2078
    neXtProt AC: NX_P11308
    UniProt: P11308

  • Chr Location
    21q22.2; chr21:38367261-38662045 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Erg mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 6 alleles in 4 genetic backgrounds
    19 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation or a knock-out of isoforms 5 - 7 die during organogenesis and exhibit embryonic growth retardation. Mice homozygous for a knock-out of isoforms 1 - 4 are viable and fertile with no overt abnnormalities. Homozygous knock-out mice develop pulmonary venoocclusive disease, with pancytopenia, pulmonary hemorrhage and hypertension, and heart right ventricle hypertrophy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000026424 VEGA Gene Model | MGI Sequence Detail 227425 C57BL/6J ±  kb
    transcript OTTMUST00000103971 VEGA | MGI Sequence Detail 3249 Not Applicable  
    polypeptide OTTMUSP00000058139 VEGA | MGI Sequence Detail 486 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      830 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 2
      cDNA 21
      Primer pair 3
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9581, MGI:2444253
    References
    more
    • Summaries
      All 139
      Developmental Gene Expression 51
      Diseases 6
      Gene Ontology 6
      Phenotypes 49
    • Earliest
      J:16358 Reddy ES, et al., The erg gene: a human gene related to the ets oncogene. Proc Natl Acad Sci U S A. 1987 Sep;84(17):6131-5
    • Latest
      J:264149 Goto S, et al., Neural retina-specific Aldh1a1 controls dorsal choroidal vascular development via Sox9 expression in retinal pigment epithelial cells. Elife. 2018 Apr 3;7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/18/2018
    MGI 6.12
    The Jackson Laboratory