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Erg Gene Detail
Summary
  • Symbol
    Erg
  • Name
    ETS transcription factor
  • Synonyms
    D030036I24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:95415
    NCBI Gene: 13876
  • Gene Overview
    MyGene.info: ERG
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:95360204-95530365 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 56.04 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    823 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95415
protein coding gene Chr16:95359169-95586593 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023076
protein coding gene Chr16:96661954-96907409 (-)
A/J MGP_AJ_G0023044
protein coding gene Chr16:92092847-92320905 (-)
AKR/J MGP_AKRJ_G0023014
protein coding gene Chr16:94938629-95159924 (-)
BALB/cJ MGP_BALBcJ_G0023046
protein coding gene Chr16:92639018-92866007 (-)
C3H/HeJ MGP_C3HHeJ_G0022807
protein coding gene Chr16:95446969-95682051 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023493
protein coding gene Chr16:99716832-99960319 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020995
protein coding gene Chr16:89960029-90180515 (-)
CAST/EiJ MGP_CASTEiJ_G0022326
protein coding gene Chr16:96232805-96463376 (-)
CBA/J MGP_CBAJ_G0022776
protein coding gene Chr16:103997172-104250944 (-)
DBA/2J MGP_DBA2J_G0022910
protein coding gene Chr16:91986167-92210392 (-)
FVB/NJ MGP_FVBNJ_G0022884
protein coding gene Chr16:91147093-91376139 (-)
LP/J MGP_LPJ_G0022980
protein coding gene Chr16:96293909-96534918 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022905
protein coding gene Chr16:108311259-108547776 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023511
protein coding gene Chr16:95451310-95682871 (-)
PWK/PhJ MGP_PWKPhJ_G0022071
protein coding gene Chr16:92265849-92490155 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021901
protein coding gene Chr16:94983524-95220773 (-)
WSB/EiJ MGP_WSBEiJ_G0022377
protein coding gene Chr16:95723238-95946596 (-)



Homology
more
  • Human Ortholog
    ERG, ETS transcription factor ERG
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ERG, ETS transcription factor ERG
    Orthology source: HGNC, HomoloGene
  • Synonyms
    erg-3, p55
  • Links
    NCBI Gene ID: 2078
    neXtProt AC: NX_P11308
    UniProt: P11308

  • Chr Location
    21q22.2; chr21:38367261-38662045 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Erg mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 6 alleles in 4 genetic backgrounds
    19 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation or a knock-out of isoforms 5 - 7 die during organogenesis and exhibit embryonic growth retardation. Mice homozygous for a knock-out of isoforms 1 - 4 are viable and fertile with no overt abnnormalities. Homozygous knock-out mice develop pulmonary venoocclusive disease, with pancytopenia, pulmonary hemorrhage and hypertension, and heart right ventricle hypertrophy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040732 Ensembl Gene Model | MGI Sequence Detail 170162 C57BL/6J ±  kb
    transcript ENSMUST00000233881 Ensembl | MGI Sequence Detail 3249 Not Applicable  
    polypeptide ENSMUSP00000156669 Ensembl | MGI Sequence Detail 486 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 2
      cDNA 21
      Primer pair 3
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9581, MGI:2444253
    References
    more
    • Summaries
      All 143
      Developmental Gene Expression 54
      Diseases 6
      Gene Ontology 7
      Phenotypes 51
    • Earliest
      J:16358 Reddy ES, et al., The erg gene: a human gene related to the ets oncogene. Proc Natl Acad Sci U S A. 1987 Sep;84(17):6131-5
    • Latest
      J:266578 Plein A, et al., Erythro-myeloid progenitors contribute endothelial cells to blood vessels. Nature. 2018 Oct;562(7726):223-228

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory