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Erg Gene Detail
Summary
  • Symbol
    Erg
  • Name
    avian erythroblastosis virus E-26 (v-ets) oncogene related
  • Synonyms
    D030036I24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:95415
    NCBI Gene: 13876
Location & Maps
more
  • Sequence Map
    Chr16:95359169-95586593 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      227425 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ERG, v-ets avian erythroblastosis virus E26 oncogene homolog
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ERG, v-ets avian erythroblastosis virus E26 oncogene homolog
    Orthology source: HGNC, HomoloGene
  • Synonyms
    erg-3, p55
  • Links
    NCBI Gene ID: 2078
    neXtProt AC: NX_P11308

  • Chr Location
    21q22.3; chr21:38367261-38661833 (-)  GRCh38.p2

Human Diseases
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  • Mutations/Alleles
    2 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 2 genetic backgrounds
    19 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (ENU)
    1
  • Targeted
    9
  • Transgenic
    2
  • Genomic Mutations
    3 involving Erg
  • Incidental Mutations
Mice homozygous for an ENU-induced mutation or a knock-out of isoforms 5 - 7 die during organogenesis and exhibit embryonic growth retardation. Mice homozygous for a knock-out of isoforms 1 - 4 are viable and fertile with no overt abnnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026424 VEGA Gene Model | MGI Sequence Detail 227425 C57BL/6J ±  kb
transcript OTTMUST00000103971 VEGA | MGI Sequence Detail 3249 Not Applicable  
polypeptide OTTMUSP00000058139 VEGA | MGI Sequence Detail 486 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    833 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 26
    Genomic 2
    cDNA 19
    Primer pair 3
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-9581, MGI:2444253
References
more
  • Summaries
    All 80
    Developmental Gene Expression 31
    Diseases 5
    Gene Ontology 6
    Phenotypes 36
  • Earliest
    J:16358 Reddy ES, et al., The erg gene: a human gene related to the ets oncogene. Proc Natl Acad Sci U S A. 1987 Sep;84(17):6131-5
  • Latest
    J:227642 Giampietro C, et al., The alternative splicing factor Nova2 regulates vascular development and lumen formation. Nat Commun. 2015;6:8479

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory