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Erg
Gene Detail
Symbol

Name
ID
Erg
avian erythroblastosis virus E-26 (v-ets) oncogene related
MGI:95415
Synonyms
D030036I24Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 16
56.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr16:95359169-95586593 bp, - strand
From VEGA annotation of GRCm38

  227425 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15848  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ERG
Protein SuperFamily: transcription factor erg
Gene Tree: Erg

Human
homologs
ERG, v-ets avian erythroblastosis virus E26 oncogene homolog
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2078
neXtProt AC: NX_P11308

Human Synonyms: erg-3, p55

Human Chr (Location): 21q22.3; chr21:38367261-38661833 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Targeted(8) Transgenic(2)
Genomic Mutations involving Erg (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced mutation or a knock-out of isoforms 5 - 7 die during organogenesis and exhibit embryonic growth retardation. Mice homozygous for a knock-out of isoforms 1 - 4 are viable and fertile with no overt abnnormalities.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Erg interacts with 261 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell differentiation, cell migration, ...
Component cytoplasm, nucleus, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (726)    Tissues (407)    Images (69)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 72
RNA in situ 636
RT-PCR 18
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ERG ; Xenbase erg    NEW 
Molecular
reagents
All nucleic(26) Genomic(2) cDNA(19) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000026424 (Evidence)
Ensembl Gene Model ENSMUSG00000040732 (Evidence)
Entrez Gene 13876 (Evidence)
UniGene 164531
DFCI TC1585243, TC1594831, TC1769176
DoTS DT.101324712, DT.94126960, DT.94126962, DT.97353841
NIA Mouse Gene Index U037336
Consensus CDS Project CCDS37411.1
International Mouse Phenotyping Consortium Status Erg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026424 VEGA Gene Model | MGI Sequence Detail 227425 C57BL/6J ±  kb
transcript OTTMUST00000103971 VEGA | MGI Sequence Detail 3249 Not Applicable 
polypeptide OTTMUSP00000058139 VEGA | MGI Sequence Detail 486 Not Applicable 

For the selected sequences
All sequences(109) RefSeq(40) UniProt(9)
Polymorphisms
RFLP(2) : SNPs within 2kb(833 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR003118 Pointed domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007173 transcriptional regulator ERG
References
(Earliest) J:16358 Reddy ES, et al., The erg gene: a human gene related to the ets oncogene. Proc Natl Acad Sci U S A. 1987 Sep;84(17):6131-5
(Latest) J:217615 Chen HI, et al., VEGF-C and aortic cardiomyocytes guide coronary artery stem development. J Clin Invest. 2014 Nov;124(11):4899-914
All references(79)
Other
accession IDs
MGD-MRK-9581, MGI:2444253

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory