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Egfr
Gene Detail
Symbol

Name
ID
Egfr
epidermal growth factor receptor
MGI:95294
Synonyms
9030024J15Rik, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, Erbb, Errb1, Wa5
Feature Type
protein coding gene
Genetic Map
Chromosome 11
9.41 cM, cytoband A1-A4
Detailed Genetic Map ± 1 cM


Mapping data(58)
Sequence Map
Chr11:16752203-16918158 bp, + strand
From VEGA annotation of GRCm38

  165956 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74545  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EGFR
Protein SuperFamily: tyrosine-protein kinase, EGF receptor type
Gene Tree: Egfr

Human
homologs
EGFR, epidermal growth factor receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1956
neXtProt AC: NX_P00533

Human Synonyms: ERBB, ERBB1, HER1, mENA, NISBD2, PIG61

Human Chr (Location): 7p12; chr7:55019032-55207338 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human EGFR

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Chemically induced (ENU)(3) Spontaneous(2) Targeted(14) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutations widely affect epithelial development. Null homozygote survival is strain dependent, with defects observed in skin, eye, brain, viscera, palate, tongue and other tisses. Other mutations produce an open eyed, curly whisker phenotype, while a dominant hypermorph yields a thickened epidermis.
 
Mutations Annotated to Human Diseases (2)    Phenotype Images(6)
Interactions
Egfr interacts with 505 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (142 annotations)
Process activation of MAPKK activity, astrocyte activation, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function actin filament binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (107 records)
Data Summary: Results (543)    Tissues (144)    Images (70)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 45
RNA in situ 470
Western blot 11
RT-PCR 17
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN egfra    NEW 
Molecular
reagents
All nucleic(40) Genomic(6) cDNA(28) Primer pair(5) Other(1)
Microarray probesets(12)
Other database
links
VEGA Gene Model OTTMUSG00000005185 (Evidence)
Ensembl Gene Model ENSMUSG00000020122 (Evidence)
Entrez Gene 13649 (Evidence)
DFCI TC1578749, TC1586294, TC1600374, TC1611508, TC1673053
DoTS DT.485854, DT.529254, DT.55146130, DT.55153052, DT.94404621
EC 2.7.10.1
Consensus CDS Project CCDS24443.1, CCDS24444.1
International Mouse Phenotyping Consortium Status Egfr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005185 VEGA Gene Model | MGI Sequence Detail 165956 C57BL/6J ±  kb
transcript OTTMUST00000011585 VEGA | MGI Sequence Detail 10208 Not Applicable 
polypeptide OTTMUSP00000005385 VEGA | MGI Sequence Detail 1210 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(4) UniProt(6)
Polymorphisms
RFLP(15) : SNPs within 2kb(1118 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000494 EGF receptor, L domain
InterPro IPR006211 Furin-like cysteine-rich domain
InterPro IPR006212 Furin-like repeat
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor
Protein Ontology PR:000006933 epidermal growth factor receptor
References
(Earliest) J:13052 Keeler CE, A second rexoid coat character in the house mouse. J Hered. 1935;26:189-191
(Latest) J:220706 Koehler JA, et al., GLP-1R agonists promote normal and neoplastic intestinal growth through mechanisms requiring Fgf7. Cell Metab. 2015 Mar 3;21(3):379-91
All references(406)
Other
accession IDs
MGD-MRK-15422, MGD-MRK-15424, MGD-MRK-9322, MGD-MRK-9570, MGI:1890525, MGI:2144221

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory