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Egfr Gene Detail
Summary
  • Symbol
    Egfr
  • Name
    epidermal growth factor receptor
  • Synonyms
    9030024J15Rik, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, Erbb, Errb1, Wa5
  • Feature Type
    protein coding gene
  • IDs
    MGI:95294
    NCBI Gene: 13649
Location & Maps
more
  • Sequence Map
    Chr11:16752203-16918158 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      165956 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    EGFR, epidermal growth factor receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EGFR, epidermal growth factor receptor
    Orthology source: HomoloGene
  • Synonyms
    ERBB, ERBB1, HER1, mENA, NISBD2, PIG61
  • Links
    NCBI Gene ID: 1956
    neXtProt AC: NX_P00533

  • Chr Location
    7p12; chr7:55019032-55207338 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human EGFR associations

Human Disease Mouse Models
       Inflammatory Skin and Bowel Disease, Neonatal, 2; NISBD2   OMIM: 616069
Lung Cancer   OMIM: 211980 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    165 phenotypes from 14 alleles in 26 genetic backgrounds
    107 phenotypes from multigenic genotypes
    6 images
    167 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Chemically induced (ENU)
    3
  • Chemically induced (other)
    1
  • Spontaneous
    2
  • Targeted
    14
  • Transgenic
    6
  • Genomic Mutations
    1 involving Egfr
  • Incidental Mutations
Mutations widely affect epithelial development. Null homozygote survival is strain dependent, with defects observed in skin, eye, brain, viscera, palate, tongue and other tisses. Other mutations produce an open eyed, curly whisker phenotype, while a dominant hypermorph yields a thickened epidermis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005185 VEGA Gene Model | MGI Sequence Detail 165956 C57BL/6J ±  kb
transcript OTTMUST00000011585 VEGA | MGI Sequence Detail 10208 Not Applicable  
polypeptide OTTMUSP00000005385 VEGA | MGI Sequence Detail 1210 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1116 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000006933 epidermal growth factor receptor
  • EC
  • InterPro Domains
    IPR006211 Furin-like cysteine-rich domain
    IPR006212 Furin-like repeat
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR032778 Growth factor receptor domain 4
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR000494 Receptor L-domain
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
    IPR008266 Tyrosine-protein kinase, active site
    IPR020635 Tyrosine-protein kinase, catalytic domain
    IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor
Molecular
Reagents
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  • All nucleic 40
    Genomic 6
    cDNA 28
    Primer pair 5
    Other 1

    Microarray probesets 12
Other
Accession IDs
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MGD-MRK-15422, MGD-MRK-15424, MGD-MRK-9322, MGD-MRK-9570, MGI:1890525, MGI:2144221
References
more
  • Summaries
    All 419
    Developmental Gene Expression 111
    Diseases 5
    Gene Ontology 35
    Phenotypes 167
  • Earliest
    J:13052 Keeler CE, A second rexoid coat character in the house mouse. J Hered. 1935;26:189-191
  • Latest
    J:229771 Kobayashi T, et al., Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis. Immunity. 2015 Apr 21;42(4):756-66

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory