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Gene Detail
epidermal growth factor receptor
Synonyms 9030024J15Rik, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, Erbb, Errb1, Wa5
Feature Type protein coding gene
Genetic Map
Chromosome 11
9.41 cM, cytoband A1-A4
Detailed Genetic Map ± 1 cM

Mapping data(58)
Sequence Map
Chr11:16752203-16918158 bp, + strand
From VEGA annotation of GRCm38

  165956 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:74545  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, EGF receptor type
Gene Tree: Egfr

Human Homolog EGFR, epidermal growth factor receptor
NCBI Gene ID 1956
neXtProt AC  NX_P00533
Human Synonyms  ERBB, ERBB1, HER1, mENA, PIG61
Human Chr (Location)  7p12; chr7:55019032-55207338 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human EGFR
alleles, and
All mutations/alleles(17) : Chemically induced (ENU)(3) Spontaneous(2) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
Mutations widely affect epithelial development. Null homozygote survival is strain dependent, with defects observed in skin, eye, brain, viscera, palate, tongue and other tisses. Other mutations produce an open eyed, curly whisker phenotype, while a dominant hypermorph yields a thickened epidermis.
Phenotype Images(6)
Egfr interacts with 506 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (139 annotations)
Process activation of MAPKK activity, astrocyte activation, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function actin filament binding, ATP binding, ...
External Resources: FuncBase
Literature Summary: (104 records)
Data Summary: Results (533)    Tissues (135)    Images (70)
Theiler Stages: 1, 2, 3, 4, 14, 16, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 35
RNA in situ 470
Western blot 11
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(39) Genomic(6) cDNA(27) Primer pair(5) Other(1)
Microarray probesets(12)
Other database
VEGA Gene ModelOTTMUSG00000005185 (Evidence)
Ensembl Gene ModelENSMUSG00000020122 (Evidence)
Entrez Gene13649 (Evidence)
DFCITC1578749, TC1586294, TC1600374, TC1611508, TC1673053
DoTSDT.485854, DT.529254, DT.55146130, DT.55153052, DT.94404621
Consensus CDS ProjectCCDS24443.1, CCDS24444.1
International Mouse Knockout Project StatusEgfr
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005185 VEGA Gene Model | MGI Sequence Detail 165956 C57BL/6J ±  kb
transcript OTTMUST00000011585 VEGA | MGI Sequence Detail 10208 Not Applicable 
polypeptide OTTMUSP00000005385 VEGA | MGI Sequence Detail 1210 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(6) UniProt(6)
Polymorphisms RFLP(15) : SNPs within 2kb(1118 from dbSNP Build 137)
InterPro IPR000494 EGF receptor, L domain
InterPro IPR006211 Furin-like cysteine-rich domain
InterPro IPR006212 Furin-like repeat
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor
Protein Ontology PR:000006933 epidermal growth factor receptor
References (Earliest) J:13052 Keeler CE, A second rexoid coat character in the house mouse. J Hered. 1935;26:189-191
(Latest) J:210895 Scheving LA, et al., Epidermal growth factor receptor plays a role in the regulation of liver and plasma lipid levels in adult male mice. Am J Physiol Gastrointest Liver Physiol. 2014 Mar 1;306(5):G370-81
All references(393)
accession IDs
MGD-MRK-15422, MGD-MRK-15424, MGD-MRK-9322, MGD-MRK-9570, MGI:1890525, MGI:2144221

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory