Egfr
Gene Detail

Symbol Name ID

Egfr epidermal growth factor receptor MGI:95294

Synonyms

9030024J15Rik, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, Erbb, Errb1, Wa5

Feature Type

protein coding gene

Genetic Map

Chromosome 11

9.41 cM, cytoband A1-A4
Detailed Genetic Map ± 1 cM


Mapping data(58)

Sequence Map

Chr11:16752203-16918158 bp, + strand From VEGA annotation of GRCm38   165956 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74545  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, EGF receptor type
Gene Tree: Egfr

Human homologs

Human Homolog		EGFR, epidermal growth factor receptor
NCBI Gene ID		1956
neXtProt AC		NX_P00533
Human Synonyms		ERBB, ERBB1, HER1, mENA, PIG61
Human Chr (Location)		7p12; chr7:55086725-55275031 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human EGFR

Alleles and phenotypes

All alleles(16) : Targeted(11) Spontaneous(2) Chemically induced(3)
 

Mutations widely affect epithelial development. Null homozygote survival is strain dependent, with defects observed in skin, eye, brain, viscera, palate, tongue and other tisses. Other mutations produce an open eyed, curly whisker phenotype, while a dominant hypermorph yields a thickened epidermis.

 
Phenotype Images(6)

Gene Ontology (GO) classifications

All GO classifications: (124 annotations)

Process	activation of MAPKK activity, astrocyte activation, ...
Component	apical plasma membrane, basolateral plasma membrane, ...
Function	actin filament binding, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (98 records)
Data Summary: Results (515)    Tissues (129)    Images (63)
Theiler Stages: 1, 2, 3, 4, 14, 16, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	26
RNA in situ	466
Western blot	7
RT-PCR	16

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(37) Genomic(6) cDNA(26) Primer pair(4) Other(1)
Microarray probesets(12)

Other database links

VEGA Gene Model	OTTMUSG00000005185 (Evidence)
Ensembl Gene Model	ENSMUSG00000020122 (Evidence)
Entrez Gene	13649 (Evidence)
DFCI	TC1578749, TC1586294, TC1600374, TC1611508, TC1673053
DoTS	DT.485854, DT.529254, DT.55146130, DT.55153052, DT.94404621
EC	2.7.10.1
Consensus CDS Project	CCDS24443.1, CCDS24444.1
International Mouse Knockout Project Status	Egfr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005185	VEGA Gene Model | MGI Sequence Detail	165956	C57BL/6J
transcript	OTTMUST00000011585	VEGA | MGI Sequence Detail	10208	Not Applicable
polypeptide	OTTMUSP00000005385	VEGA | MGI Sequence Detail	1210	Not Applicable

All sequences(71) RefSeq(4) UniProt(6)

Polymorphisms

RFLP(15) : SNPs(841 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000494	EGF receptor, L domain
InterPro	IPR006211	Furin-like cysteine-rich domain
InterPro	IPR006212	Furin-like repeat
InterPro	IPR009030	Insulin-like growth factor binding protein, N-terminal
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR016245	Tyrosine protein kinase, EGF/ERB/XmrK receptor
Protein Ontology	PR:000006933	epidermal growth factor receptor

References

(Earliest) J:13052 Keeler CE, A second rexoid coat character in the house mouse. J Hered. 1935;26:189-191
(Latest) J:195804 Saito K, et al., Conditional inactivation of TNFalpha-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones. PLoS One. 2013;8(1):e54853
All references(364)

Other accession IDs

MGD-MRK-15422, MGD-MRK-15424, MGD-MRK-9322, MGD-MRK-9570, MGI:1890525, MGI:2144221