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Egfr Gene Detail
Summary
  • Symbol
    Egfr
  • Name
    epidermal growth factor receptor
  • Synonyms
    9030024J15Rik, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, Erbb, Errb1, Wa5
  • Feature Type
    protein coding gene
  • IDs
    MGI:95294
    NCBI Gene: 13649
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:16752203-16918158 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      165956 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 9.41 cM, cytoband A1-A4
  • Mapping Data
    58 experiments
Homology
more
  • Human Ortholog
    EGFR, epidermal growth factor receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EGFR, epidermal growth factor receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ERBB, ERBB1, HER1, mENA, NISBD2, PIG61
  • Links
    NCBI Gene ID: 1956
    neXtProt AC: NX_P00533
    UniProt: P00533

  • Chr Location
    7p11.2; chr7:55019032-55207338 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Egfr mouse models; 1 with human EGFR associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    10 with disease annotations
  • References
    9 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    185 phenotypes from 15 alleles in 28 genetic backgrounds
    118 phenotypes from multigenic genotypes
    6 images
    200 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations widely affect epithelial development. Null homozygote survival is strain dependent, with defects observed in skin, eye, brain, viscera, palate, tongue and other tisses. Other mutations produce an open eyed, curly whisker phenotype, while a dominant hypermorph yields a thickened epidermis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005185 VEGA Gene Model | MGI Sequence Detail 165956 C57BL/6J ±  kb
    transcript OTTMUST00000011585 VEGA | MGI Sequence Detail 10208 Not Applicable  
    polypeptide OTTMUSP00000005385 VEGA | MGI Sequence Detail 1210 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1116 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 6
      cDNA 30
      Primer pair 5
      Other 1

      Microarray probesets 12
    Other
    Accession IDs
    less
    MGD-MRK-15422, MGD-MRK-15424, MGD-MRK-9322, MGD-MRK-9570, MGI:1890525, MGI:2144221
    References
    more
    • Summaries
      All 603
      Developmental Gene Expression 126
      Diseases 9
      Gene Ontology 37
      Phenotypes 200
    • Earliest
      J:13052 Keeler CE, A second rexoid coat character in the house mouse. J Hered. 1935;26:189-191
    • Latest
      J:261714 Ali A, et al., Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer. EMBO Mol Med. 2018 Feb 15;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory