Phenotypes Associated with This Genotype

Genotype
MGI:6403356

• Allelic Composition: Egfr^Mhdadsk5/Egfr⁺
• Genetic Background: involves: 129S1/SvImJ * C3HeB/FeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to Coronaviridae infection ( J:243599 )

• mice infected with a mouse adapted (MA15) version of severe acute respiratory syndrome coronavirus (SARS-CoV) show enhanced lung damage compared to wild-type mice, showing increased perivascular inflammation with interstitial edema, and alveolar and interstitial spaces filled with proteinaceous fluid and inflammatory cells, however they show a similar weight loss, viral titer, and recovery as wild-type control mice

• aged mice (20-24 weeks old) show increased susceptibility to SARS-CoV infection compared to older wild-type mice, showing higher levels of lung damage, increased edema, perivascular cuffing, interstitial inflammation and cuffing around airways, and enhanced cellular proliferation in lungs

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:243599 )

• aged mice infected with SARS-CoV show 80% lethality by 5 dpi compared to 30% lethality in wild-type controls

mortality/aging

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:243599 )

• aged mice infected with SARS-CoV show 80% lethality by 5 dpi compared to 30% lethality in wild-type controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Coronavirus infectious disease		DOID:0080599		J:243599