Symbol
Name
ID

Egfr
epidermal growth factor receptor
MGI:95294

Phenotype annotations related to integument

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Breast carcinoma	Jaundice
Disease(s) Associated with EGFR	Breast carcinoma	Jaundice
pancreatic cancer

Mouse Phenotypes

integument phenotype

abnormal mammary gland morphology

abnormal lactation

impaired skin barrier function

dermatitis

abnormal coat appearance

abnormal hair growth

alopecia

delayed hair appearance

short hair

abnormal hair texture

rough coat

disheveled coat

plush coat

waved hair

increased curvature of guard hairs

abnormal hair shaft morphology

abnormal hair cortex keratinization

abnormal hair medulla

increased curvature of hairs

abnormal nail morphology

long toenails

abnormal hair follicle morphology

abnormal hair follicle development

abnormal hair follicle inner root sheath morphology

abnormal hair follicle orientation

distorted hair follicle pattern

abnormal vibrissa morphology

absent vibrissae

curly vibrissae

loss of vibrissae

short vibrissae

wavy vibrissae

abnormal skin morphology

abnormal epidermal layer morphology

abnormal epidermis stratum basale morphology

abnormal epidermis stratum corneum morphology

abnormal epidermis stratum granulosum morphology

thick epidermis

thin epidermis

abnormal skin appearance

dry skin

flaky skin

petechiae

abnormal skin pigmentation

increased foot pad pigmentation

thick skin

Availability

Mouse Genotype

Egfr^m2Btlr/Egfr^m2Btlr

Egfr^Mhdadsk5/Egfr^Mhdadsk5

Egfr^tm1.1Dwt/Egfr^tm1.1Dwt

Egfr^tm1Mag/Egfr^tm1Mag

Egfr^tm1Rdk/Egfr^tm1Rdk

Egfr^tm1Wag/Egfr^tm1Wag

Egfr^wa2-4J/Egfr^wa2-4J

Egfr^wa2/Egfr^wa2

Egfr^Mhdadsk5/Egfr⁺

Egfr^tm1Dwt/Egfr^tm1Mag

Egfr^Vel/Egfr⁺

Egfr^wa2/Egfr^Wa5

Egfr^Wa5/Egfr⁺

Egfr^tm1Dwt/Egfr^tm1Dwt
Tg(KRT14-cre)1Amc/0 (conditional)

Egfr^tm1Dwt/Egfr^tm1Dwt
Sox9^tm3(cre)Crm/Sox9⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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