About   Help   FAQ
Dpp4
Gene Detail
Symbol

Name
ID
Dpp4
dipeptidylpeptidase 4
MGI:94919
Synonyms
Cd26, Dpp-4, THAM
Feature Type
protein coding gene
Genetic Map
Chromosome 2
35.85 cM, cytoband C2-D
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr2:62330073-62412231 bp, - strand
From VEGA annotation of GRCm38

  82159 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3279  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: DPP4
Protein SuperFamily: dipeptidyl-peptidase IV
Gene Tree: Dpp4

Human
homologs
DPP4, dipeptidyl-peptidase 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1803
neXtProt AC: NX_P27487

Human Synonyms: ADABP, ADCP2, CD26, DPPIV, TP103

Human Chr (Location): 2q24.3; chr2:161992241-162074542 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(7) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants show hypoglycemia, hyperinsulinemia, and increased plasma glucagon-like peptide 1 in glucose tolerance tests.
 
Interactions
Dpp4 interacts with 378 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process behavioral fear response, cell adhesion, ...
Component apical plasma membrane, cell junction, ...
Function aminopeptidase activity, collagen binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (92)    Tissues (26)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 83
RNase protection 6
cDNA source data(70)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dpp4    NEW 
Molecular
reagents
All nucleic(86) Genomic(14) cDNA(71) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000012759 (Evidence)
Ensembl Gene Model ENSMUSG00000035000 (Evidence)
Entrez Gene 13482 (Evidence)
UniGene 1151
DFCI TC1576819, TC1624232
DoTS DT.101213418, DT.101349793, DT.493760
NIA Mouse Gene Index U022673
EC 3.4.14.5
Consensus CDS Project CCDS16065.1
International Mouse Phenotyping Consortium Status Dpp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012759 VEGA Gene Model | MGI Sequence Detail 82159 C57BL/6J ±  kb
transcript OTTMUST00000030489 VEGA | MGI Sequence Detail 5268 Not Applicable 
polypeptide OTTMUSP00000013700 VEGA | MGI Sequence Detail 760 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(12) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(482 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR029058 Alpha/Beta hydrolase fold
InterPro IPR002469 Dipeptidylpeptidase IV, N-terminal domain
InterPro IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
InterPro IPR002471 Peptidase S9, serine active site
Protein Ontology PR:000001341 dipeptidyl peptidase IV
References
(Earliest) J:1599 Marguet D, et al., cDNA cloning for mouse thymocyte-activating molecule. A multifunctional ecto-dipeptidyl peptidase IV (CD26) included in a subgroup of serine proteases. J Biol Chem. 1992 Feb 5;267(4):2200-8
(Latest) J:221834 Sueyoshi R, et al., Stimulation of intestinal growth and function with DPP4 inhibition in a mouse short bowel syndrome model. Am J Physiol Gastrointest Liver Physiol. 2014 Aug 15;307(4):G410-9
All references(82)
Other
accession IDs
MGD-MRK-1843, MGD-MRK-8884, MGD-MRK-8887

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory