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Dpp4
Gene Detail
 Symbol
Name
ID
Dpp4
dipeptidylpeptidase 4
MGI:94919
Synonyms Cd26, Dpp-4, THAM
Feature Type protein coding gene
Genetic Map
Chromosome 2
35.85 cM, cytoband C2-D
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr2:62330073-62412231 bp, - strand
From VEGA annotation of GRCm38

  82159 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3279  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: dipeptidyl-peptidase IV
Gene Tree: Dpp4

Human
homologs
Human Homolog DPP4, dipeptidyl-peptidase 4
NCBI Gene ID 1803
neXtProt AC  NX_P27487
Human Synonyms  ADABP, ADCP2, CD26, DPPIV, TP103
Human Chr (Location)  2q24.3; chr2:161992241-162074542 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(7) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants show hypoglycemia, hyperinsulinemia, and increased plasma glucagon-like peptide 1 in glucose tolerance tests.
 
Interactions
Dpp4 interacts with 379 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process cell adhesion, endothelial cell migration, ...
Component apical plasma membrane, cell junction, ...
Function aminopeptidase activity, collagen binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (92)    Tissues (25)    Images (25)
Theiler Stages: 11, 12, 13, 15, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 83
RNase protection 6
cDNA source data(69)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(85) Genomic(14) cDNA(70) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000012759 (Evidence)
Ensembl Gene ModelENSMUSG00000035000 (Evidence)
Entrez Gene13482 (Evidence)
UniGene1151
DFCITC1576819, TC1624232
DoTSDT.101213418, DT.101349793, DT.493760
NIA Mouse Gene IndexU022673
EC3.4.14.5
Consensus CDS ProjectCCDS16065.1
International Mouse Knockout Project StatusDpp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012759 VEGA Gene Model | MGI Sequence Detail 82159 C57BL/6J ±  kb
transcript OTTMUST00000030489 VEGA | MGI Sequence Detail 5268 Not Applicable 
polypeptide OTTMUSP00000013700 VEGA | MGI Sequence Detail 760 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(13) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(482 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002469 Peptidase S9B, dipeptidylpeptidase IV N-terminal
InterPro IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
InterPro IPR002471 Peptidase S9, serine active site
Protein Ontology PR:000001341 dipeptidyl peptidase IV
References (Earliest) J:1599 Marguet D, et al., cDNA cloning for mouse thymocyte-activating molecule. A multifunctional ecto-dipeptidyl peptidase IV (CD26) included in a subgroup of serine proteases. J Biol Chem. 1992 Feb 5;267(4):2200-8
(Latest) J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
All references(81)
Other
accession IDs
MGD-MRK-1843, MGD-MRK-8884, MGD-MRK-8887

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory