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Dpp4 Gene Detail
Summary
  • Symbol
    Dpp4
  • Name
    dipeptidylpeptidase 4
  • Synonyms
    Cd26, Dpp-4, THAM
  • Feature Type
    protein coding gene
  • IDs
    MGI:94919
    NCBI Gene: 13482
  • Gene Overview
    MyGene.info: DPP4
Location & Maps
more
  • Sequence Map
    Chr2:62330073-62412231 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      82159 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 35.85 cM, cytoband C2-D
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    DPP4, dipeptidyl peptidase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DPP4, dipeptidyl peptidase 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADABP, ADCP2, CD26, DPPIV, TP103
  • Links
    NCBI Gene ID: 1803
    neXtProt AC: NX_P27487

  • Chr Location
    2q24.3; chr2:161992241-162074542 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Targeted
    7
  • Genomic Mutations
    1 involving Dpp4
  • Incidental Mutations
Homozygous mutants show hypoglycemia, hyperinsulinemia, and increased plasma glucagon-like peptide 1 in glucose tolerance tests.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012759 VEGA Gene Model | MGI Sequence Detail 82159 C57BL/6J ±  kb
transcript OTTMUST00000030489 VEGA | MGI Sequence Detail 5268 Not Applicable  
polypeptide OTTMUSP00000013700 VEGA | MGI Sequence Detail 760 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    474 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001341 dipeptidyl peptidase IV
  • EC
  • InterPro Domains
    IPR029058 Alpha/Beta hydrolase fold
    IPR002469 Dipeptidylpeptidase IV, N-terminal domain
    IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
    IPR002471 Peptidase S9, serine active site
Molecular
Reagents
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  • All nucleic 86
    Genomic 14
    cDNA 71
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1843, MGD-MRK-8884, MGD-MRK-8887
References
more
  • Summaries
    All 81
    Developmental Gene Expression 16
    Gene Ontology 6
    Phenotypes 27
  • Earliest
    J:1599 Marguet D, et al., cDNA cloning for mouse thymocyte-activating molecule. A multifunctional ecto-dipeptidyl peptidase IV (CD26) included in a subgroup of serine proteases. J Biol Chem. 1992 Feb 5;267(4):2200-8
  • Latest
    J:227036 Hirukawa H, et al., Combination of DPP-4 inhibitor and PPARgamma agonist exerts protective effects on pancreatic beta-cells in diabetic db/db mice through the augmentation of IRS-2 expression. Mol Cell Endocrinol. 2015 Sep 15;413:49-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory