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Dpp4 Gene Detail
Summary
  • Symbol
    Dpp4
  • Name
    dipeptidylpeptidase 4
  • Synonyms
    Cd26, Dpp-4, THAM
  • Feature Type
    protein coding gene
  • IDs
    MGI:94919
    NCBI Gene: 13482
  • Gene Overview
    MyGene.info: DPP4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:62330073-62412231 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      82159 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 35.85 cM, cytoband C2-D
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    DPP4, dipeptidyl peptidase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DPP4, dipeptidyl peptidase 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADABP, ADCP2, CD26, DPPIV, TP103
  • Links
    NCBI Gene ID: 1803
    neXtProt AC: NX_P27487
    UniProt: P27487

  • Chr Location
    2q24.2; chr2:161992241-162074542 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants show hypoglycemia, hyperinsulinemia, and increased plasma glucagon-like peptide 1 in glucose tolerance tests.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000012759 VEGA Gene Model | MGI Sequence Detail 82159 C57BL/6J ±  kb
    transcript OTTMUST00000030489 VEGA | MGI Sequence Detail 5268 Not Applicable  
    polypeptide OTTMUSP00000013700 VEGA | MGI Sequence Detail 760 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      474 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 87
      Genomic 14
      cDNA 72
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1843, MGD-MRK-8884, MGD-MRK-8887
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 18
      Gene Ontology 5
      Phenotypes 32
    • Earliest
      J:1599 Marguet D, et al., cDNA cloning for mouse thymocyte-activating molecule. A multifunctional ecto-dipeptidyl peptidase IV (CD26) included in a subgroup of serine proteases. J Biol Chem. 1992 Feb 5;267(4):2200-8
    • Latest
      J:261803 Ghorpade DS, et al., Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance. Nature. 2018 Mar 29;555(7698):673-677

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory