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Targeted Allele Detail
Symbol: Dpp4tm1.1(DPP4)Pbmj
Name: dipeptidylpeptidase 4; targeted mutation 1.1, Paul B McCray Jr
MGI ID: MGI:6400999
Synonyms: hDPP4-KI
Gene: Dpp4  Location: Chr2:62160417-62242575 bp, - strand  Genetic Position: Chr2, 35.85 cM, cytoband C2-D
Alliance: Dpp4tm1.1(DPP4)Pbmj page
Germline Transmission:  Earliest citation of germline transmission: J:242025
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
Dpp4tm1.1(DPP4)Pbmj expresses 1 gene
Mutation detailsExons 10-12 (from codon I264 in exon 10 to codon V340 in exon 12) of the mouse were replaced with the corresponding human exons of 10-12 which comprise the critical Middle East respiratory syndrome coronavirus (MERS-CoV) receptor. A neomycin resistance gene flanked by FRT sites and a puromycin resistance gene flanked by F3 sites were inserted in intron 9 and intron 12, respectively. The selection markers were removed via Flp-mediated recombination. (J:242025)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dpp4 Mutation:  51 strains or lines available
Original:  J:242025 Li K, et al., Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3119-E3128
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory