Slc6a3
Gene Detail

Symbol Name ID

Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 MGI:94862

Synonyms

DAT, Dat1

Feature Type

protein coding gene

Genetic Map

Chromosome 13

40.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr13:73536747-73578672 bp, + strand From NCBI annotation of GRCm38   41926 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55547  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Gene Tree: Slc6a3

Human homologs

Human Homolog		SLC6A3, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
NCBI Gene ID		6531
neXtProt AC		NX_Q01959
Human Synonyms		DAT, DAT1, PKDYS
Human Chr (Location)		5p15.3; chr5:1392905-1445543 (-)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human SLC6A3

Alleles and phenotypes

All alleles(16) : Targeted(15) Gene trapped(1)
 

Homozygotes for targeted null mutations exhibit dwarfism, hyperactivity (especially in a novel environment), 5-fold higher extracellular dopamine levels, impaired spatial cognitive function, anterior pituitary hypoplasia, and failure to lactate.

 
Human Diseases Modeled Using Mouse Slc6a3 (4)    Alleles Annotated to Human Diseases(7)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (43 annotations)

Process	adenohypophysis development, dopamine biosynthetic process, ...
Component	axon, integral to membrane, ...
Function	dopamine binding, dopamine:sodium symporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (38 records)
Data Summary: Results (118)    Tissues (105)    Images (10)
Theiler Stages: 22, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	14
RNA in situ	97
In situ reporter (knock in)	4
Western blot	3

cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(1) cDNA(11) Primer pair(1) Other(4)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000021609 (Evidence)
Entrez Gene	13162 (Evidence)
UniGene	41993
DFCI	TC1582804
DoTS	DT.40151998
NIA Mouse Gene Index	U014999
Consensus CDS Project	CCDS26632.1
International Mouse Knockout Project Status	Slc6a3

Sequences

Length	Strain/Species
genomic	13162	NCBI Gene Model | MGI Sequence Detail	41926	C57BL/6J
transcript	NM_010020	RefSeq | MGI Sequence Detail	3456	C57BL/6
polypeptide	Q61327	UniProt | EBI | MGI Sequence Detail	619	Not Applicable

All sequences(22) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(219 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000175	Sodium:neurotransmitter symporter
InterPro	IPR002436	Sodium:neurotransmitter symporter, dopamine
Protein Ontology	PR:000015188	sodium-dependent dopamine transporter

Graphical View of Protein Domain Structure

References

(Earliest) J:16820 Lossie AC, et al., Localization of the dopamine transporter gene, Dat1, on mouse chromosome 13. Mamm Genome. 1994 Feb;5(2):117-8
(Latest) J:192664 Uchiumi O, et al., Serotonergic involvement in the amelioration of behavioral abnormalities in dopamine transporter knockout mice by nicotine. Neuropharmacology. 2013 Jan;64:348-56
All references(218)

Other accession IDs

MGD-MRK-8798