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Slc6a3
Gene Detail
 Symbol
Name
ID
Slc6a3
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
MGI:94862
Synonyms DAT, Dat1
Feature Type protein coding gene
Genetic Map
Chromosome 13
40.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:73536747-73578672 bp, + strand
From NCBI annotation of GRCm38

  41926 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55547  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Slc6a3

Human
homologs
Human Homolog SLC6A3, solute carrier family 6 (neurotransmitter transporter), member 3
NCBI Gene ID 6531
neXtProt AC  NX_Q01959
Human Synonyms  DAT, DAT1, PKDYS
Human Chr (Location)  5p15.3; chr5:1392790-1445428 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human SLC6A3
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(1) Targeted(16)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit dwarfism, hyperactivity (especially in a novel environment), 5-fold higher extracellular dopamine levels, impaired spatial cognitive function, anterior pituitary hypoplasia, and failure to lactate.
 
Human Diseases Modeled Using Mouse Slc6a3 (4)    Alleles Annotated to Human Diseases(7)    Phenotype Images(1)
Interactions
Slc6a3 interacts with 196 markers (Mir7-1, Mir15a, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process adenohypophysis development, cation transmembrane transport, ...
Component axon, integral component of membrane, ...
Function dopamine binding, dopamine:sodium symporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (41 records)
Data Summary: Results (140)    Tissues (128)    Images (11)
Theiler Stages: 22, 23, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 14
RNA in situ 119
In situ reporter (knock in) 4
Western blot 3
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(1) cDNA(11) Primer pair(1) Other(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021609 (Evidence)
Entrez Gene13162 (Evidence)
UniGene41993
DFCITC1582804
DoTSDT.40151998
NIA Mouse Gene IndexU014999
Consensus CDS ProjectCCDS26632.1
International Mouse Knockout Project StatusSlc6a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13162 NCBI Gene Model | MGI Sequence Detail 41926 C57BL/6J ±  kb
transcript NM_010020 RefSeq | MGI Sequence Detail 3456 C57BL/6 
polypeptide Q61327 UniProt | EBI | MGI Sequence Detail 619 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(9) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(242 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000175 Sodium:neurotransmitter symporter
InterPro IPR002436 Sodium:neurotransmitter symporter, dopamine
Protein Ontology PR:000015188 sodium-dependent dopamine transporter
Graphical View of Protein Domain Structure
References (Earliest) J:16820 Lossie AC, et al., Localization of the dopamine transporter gene, Dat1, on mouse chromosome 13. Mamm Genome. 1994 Feb;5(2):117-8
(Latest) J:212150 Ferris MJ, et al., Dopamine transporters govern diurnal variation in extracellular dopamine tone. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):E2751-9
All references(246)
Disease annotation references (6)
Other
accession IDs
MGD-MRK-8798

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory