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Slc6a3
Gene Detail
Symbol

Name
ID
Slc6a3
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
MGI:94862
Synonyms
DAT, Dat1
Feature Type
protein coding gene
Genetic Map
Chromosome 13
40.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:73536747-73578672 bp, + strand
From Ensembl annotation of GRCm38

  41926 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55547  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC6A3
Gene Tree: Slc6a3

Human
homologs
SLC6A3, solute carrier family 6 (neurotransmitter transporter), member 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6531
neXtProt AC: NX_Q01959

Human Synonyms: DAT, DAT1, PKDYS

Human Chr (Location): 5p15.3; chr5:1392790-1445428 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SLC6A3

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(1) Targeted(18)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit dwarfism, hyperactivity (especially in a novel environment), 5-fold higher extracellular dopamine levels, impaired spatial cognitive function, anterior pituitary hypoplasia, and failure to lactate.
 
Human Diseases Modeled in Mice Using Slc6a3 (4)    Mutations Annotated to Human Diseases (7)    Phenotype Images(1)
Interactions
Slc6a3 interacts with 196 markers (Mir7-1, Mir15a, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process adenohypophysis development, ammonium transmembrane transport, ...
Component axon, cell surface, ...
Function dopamine binding, dopamine:sodium symporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (44 records)
Data Summary: Results (140)    Tissues (128)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 119
In situ reporter (knock in) 4
Western blot 3
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: ZFIN slc6a3    NEW 
Molecular
reagents
All nucleic(17) Genomic(1) cDNA(11) Primer pair(1) Other(4)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000021609 (Evidence)
Entrez Gene 13162 (Evidence)
UniGene 41993
DFCI TC1582804
DoTS DT.40151998
NIA Mouse Gene Index U014999
Consensus CDS Project CCDS26632.1
International Mouse Phenotyping Consortium Status Slc6a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021609 Ensembl Gene Model | MGI Sequence Detail 41926 C57BL/6J ±  kb
transcript ENSMUST00000022100 Ensembl | MGI Sequence Detail 3456 Not Applicable 
polypeptide ENSMUSP00000022100 Ensembl | MGI Sequence Detail 619 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(9) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(242 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000175 Sodium:neurotransmitter symporter
InterPro IPR002436 Sodium:neurotransmitter symporter, dopamine
Protein Ontology PR:000015188 sodium-dependent dopamine transporter
References
(Earliest) J:16820 Lossie AC, et al., Localization of the dopamine transporter gene, Dat1, on mouse chromosome 13. Mamm Genome. 1994 Feb;5(2):117-8
(Latest) J:219705 Lammel S, et al., Diversity of transgenic mouse models for selective targeting of midbrain dopamine neurons. Neuron. 2015 Jan 21;85(2):429-38
All references(261)
Disease annotation references (7)
Other
accession IDs
MGD-MRK-8798

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory