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Slc6a3 Gene Detail
Summary
  • Symbol
    Slc6a3
  • Name
    solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
  • Synonyms
    DAT, Dat1
  • Feature Type
    protein coding gene
  • IDs
    MGI:94862
    NCBI Gene: 13162
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:73684866-73726791 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    238 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94862
protein coding gene Chr13:73684270-73726791 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020746
protein coding gene Chr13:73987061-74032682 (+)
A/J MGP_AJ_G0020702
protein coding gene Chr13:71357605-71399494 (+)
AKR/J MGP_AKRJ_G0020676
protein coding gene Chr13:73598980-73645134 (+)
BALB/cJ MGP_BALBcJ_G0020699
protein coding gene Chr13:71848139-71891098 (+)
C3H/HeJ MGP_C3HHeJ_G0020493
protein coding gene Chr13:73279782-73322800 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021136
protein coding gene Chr13:76462093-76505123 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018703
protein coding gene Chr13:68176924-68216378 (+)
CAST/EiJ MGP_CASTEiJ_G0020010
protein coding gene Chr13:72358569-72400196 (+)
CBA/J MGP_CBAJ_G0020452
protein coding gene Chr13:79302421-79349811 (+)
DBA/2J MGP_DBA2J_G0020577
protein coding gene Chr13:71177044-71220690 (+)
FVB/NJ MGP_FVBNJ_G0020557
protein coding gene Chr13:70199624-70242006 (+)
LP/J MGP_LPJ_G0020650
protein coding gene Chr13:74234400-74278552 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020585
protein coding gene Chr13:77739873-77783767 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021175
protein coding gene Chr13:72906796-72952947 (+)
PWK/PhJ MGP_PWKPhJ_G0019764
protein coding gene Chr13:69910852-69953482 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019587
protein coding gene Chr13:69369490-69413833 (+)
WSB/EiJ MGP_WSBEiJ_G0020068
protein coding gene Chr13:73455053-73496739 (+)



Homology
more
  • Human Ortholog
    SLC6A3, solute carrier family 6 member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC6A3, solute carrier family 6 member 3
  • Synonyms
    DAT, DAT1, PKDYS, PKDYS1
  • Links
    NCBI Gene ID: 6531
    neXtProt AC: NX_Q01959
    UniProt: Q01959

  • Chr Location
    5p15.33; chr5:1392794-1445440 (-)  GRCh38

Human Diseases
more
  • Diseases
    3 with Slc6a3 mouse models; 4 with human SLC6A3 associations

Human Disease Mouse Models
      
IDs
View 4 models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    8 with disease annotations
  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    64 phenotypes from 14 alleles in 15 genetic backgrounds
    103 phenotypes from multigenic genotypes
    3 images
    585 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit dwarfism, hyperactivity (especially in a novel environment), 5-fold higher extracellular dopamine levels, impaired spatial cognitive function, anterior pituitary hypoplasia, and failure to lactate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021609 Ensembl Gene Model | MGI Sequence Detail 41926 C57BL/6J ±  kb
    transcript ENSMUST00000022100 Ensembl | MGI Sequence Detail 3456 Not Applicable  
    polypeptide ENSMUSP00000022100 Ensembl | MGI Sequence Detail 619 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 14
      Primer pair 2
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-8798
    References
    more
    • Summaries
      All 706
      Developmental Gene Expression 80
      Diseases 12
      Gene Ontology 21
      Phenotypes 585
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345693 van Hoogstraten WS, et al., Disynaptic Inhibitory Cerebellar Control Over Caudal Medial Accessory Olive. eNeuro. 2024 Feb;11(2):ENEURO.0262-23.2023

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory