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Cyp2e1
Gene Detail
 Symbol
Name
ID
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
MGI:88607
Synonyms Cyp2e
Feature Type protein coding gene
Genetic Map
Chromosome 7
85.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr7:140763832-140774981 bp, + strand
From NCBI annotation of GRCm38

  11150 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68089  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp2e1

Human
homologs
Human Homolog CYP2E1, cytochrome P450, family 2, subfamily E, polypeptide 1
NCBI Gene ID 1571
neXtProt AC  NX_P05181
Human Synonyms  CPE1, CYP2E, P450C2E, P450-J
Human Chr (Location)  10q26.3; chr10:133527363-133539116 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele exhibit altered responses to xenobiotics including decreased urethane-induced tumors and allylnitrile- or acetamenophen-associated mortality but increased allylnitrile-induced vestibular function loss.
 
Interactions
Cyp2e1 interacts with 34 markers (Mir10a, Mir10b, Mir132, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (65 annotations)
Process drug metabolic process, heterocycle metabolic process, ...
Component endoplasmic reticulum, Golgi membrane, ...
Function 1-hydroxy-2-naphthoate hydroxylase activity, 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (106)    Tissues (106)   
Theiler Stages: 10, 18, 22, 23, 25, 28
Assay TypeResults
RNA in situ 94
RT-PCR 12
cDNA source data(810)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(814) Genomic(2) cDNA(811) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000025479 (Evidence)
Entrez Gene13106 (Evidence)
UniGene21758
DFCITC1582303, TC1593359, TC1601937, TC1691038
DoTSDT.101365745, DT.91358082, DT.97413039
NIA Mouse Gene IndexU008934
EC1.14.13.-, 1.14.13.n7
Consensus CDS ProjectCCDS21985.1
International Mouse Knockout Project StatusCyp2e1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13106 NCBI Gene Model | MGI Sequence Detail 11150 C57BL/6J ±  kb
transcript NM_021282 RefSeq | MGI Sequence Detail 1759 FVB/N 
polypeptide Q05421 UniProt | EBI | MGI Sequence Detail 493 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(123 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
InterPro IPR008070 Cytochrome P450, E-class, group I, CYP2E-like
Protein Ontology PR:000006122 cytochrome P450 2E1
Graphical View of Protein Domain Structure
References (Earliest) J:9095 Umeno M, et al., The rat P450IIE1 gene: complete intron and exon sequence, chromosome mapping, and correlation of developmental expression with specific 5' cytosine demethylation. J Biol Chem. 1988 Apr 5;263(10):4956-62
(Latest) J:210051 Zhou R, et al., Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis. Biochim Biophys Acta. 2014 Jan;1840(1):209-18
All references(108)
Other
accession IDs
MGD-MRK-2326, MGD-MRK-2327

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory