Cyp2e1
Gene Detail

Symbol Name ID

Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 MGI:88607

Synonyms

Cyp2e

Feature Type

protein coding gene

Genetic Map

Chromosome 7

85.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr7:140763832-140774981 bp, + strand From NCBI annotation of GRCm38   11150 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68089  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp2e1

Human homologs

Human Homolog		CYP2E1, cytochrome P450, family 2, subfamily E, polypeptide 1
NCBI Gene ID		1571
neXtProt AC		NX_P05181
Human Synonyms		CPE1, CYP2E, P450C2E, P450-J
Human Chr (Location)		10q24.3-qter; chr10:135340867-135352620 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a null allele exhibit altered responses to xenobiotics including decreased urethane-induced tumors and allylnitrile- or acetamenophen-associated mortality but increased allylnitrile-induced vestibular function loss.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	drug metabolic process, heterocycle metabolic process, ...
Component	endoplasmic reticulum, Golgi membrane, ...
Function	electron carrier activity, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (106)    Tissues (106)   
Theiler Stages: 10, 18, 22, 23, 25, 28

Assay Type	Results
RNA in situ	94
RT-PCR	12

cDNA source data(810)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(814) Genomic(2) cDNA(811) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000025479 (Evidence)
Entrez Gene	13106 (Evidence)
UniGene	21758
DFCI	TC1582303, TC1593359, TC1601937, TC1691038
DoTS	DT.101365745, DT.91358082, DT.97413039
NIA Mouse Gene Index	U008934
EC	1.14.13.-, 1.14.13.n7
Consensus CDS Project	CCDS21985.1
International Mouse Knockout Project Status	Cyp2e1

Sequences

Length	Strain/Species
genomic	13106	NCBI Gene Model | MGI Sequence Detail	11150	C57BL/6J
transcript	NM_021282	RefSeq | MGI Sequence Detail	1759	FVB/N
polypeptide	Q05421	UniProt | EBI | MGI Sequence Detail	493	Not Applicable

All sequences(27) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(117 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001128	Cytochrome P450
InterPro	IPR017972	Cytochrome P450, conserved site
InterPro	IPR002401	Cytochrome P450, E-class, group I
InterPro	IPR008070	Cytochrome P450, E-class, group I, CYP2E-like
Protein Ontology	PR:000006122	cytochrome P450 2E1

Graphical View of Protein Domain Structure

References

(Earliest) J:9095 Umeno M, et al., The rat P450IIE1 gene: complete intron and exon sequence, chromosome mapping, and correlation of developmental expression with specific 5' cytosine demethylation. J Biol Chem. 1988 Apr 5;263(10):4956-62
(Latest) J:193216 Zhang RH, et al., Inhibition of CYP2E1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction and apoptosis. Biochim Biophys Acta. 2013 Jan;1832(1):128-41
All references(99)

Other accession IDs

MGD-MRK-2326, MGD-MRK-2327