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F8
Gene Detail
Symbol

Name
ID
F8
coagulation factor VIII
MGI:88383
Synonyms
Cf8, Cf-8, Factor VIII, FVIII
Feature Type
protein coding gene
Genetic Map
Chromosome X
38.17 cM, cytoband A7-B
Detailed Genetic Map ± 1 cM


Mapping data(28)
Sequence Map
ChrX:75172715-75382615 bp, - strand
From VEGA annotation of GRCm38

  209901 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49153  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: coagulation factor V/coagulation factor VIII
Gene Tree: F8

Human
homologs
Human Homolog F8, coagulation factor VIII, procoagulant component
NCBI Gene ID 2157
neXtProt AC  NX_P00451
Human Synonyms  AHF, DXS1253E, F8B, F8C, FVIII, HEMA
Human Chr (Location)  Xq28; chrX:154835788-155022723 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Male hemizygotes and female homozygotes for targeted null mutations produce no factor VIII, but are apparently healthy and fertile. However, affected mice show prolonged, exsanguinating bleeding following tail-clipping.
 
Human Diseases Modeled Using Mouse F8 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
F8 interacts with 116 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process acute-phase response, blood coagulation, ...
Component extracellular region, extracellular space
Function copper ion binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (62)    Tissues (56)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 1
RT-PCR 55
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(1) cDNA(19) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000020850 (Evidence)
Ensembl Gene ModelENSMUSG00000031196 (Evidence)
Entrez Gene14069 (Evidence)
UniGene1805
DFCITC1586398, TC1670043
DoTSDT.40185534
NIA Mouse Gene IndexU039478
Consensus CDS ProjectCCDS30238.1, CCDS53114.1
International Mouse Knockout Project StatusF8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020850 VEGA Gene Model | MGI Sequence Detail 209901 C57BL/6J ±  kb
transcript OTTMUST00000049293 VEGA | MGI Sequence Detail 9784 Not Applicable 
polypeptide OTTMUSP00000022815 VEGA | MGI Sequence Detail 2319 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(14) UniProt(7)
Polymorphisms
RFLP(4) : SNPs within 2kb(256 from dbSNP Build 137)    SNPs within 2kb including multiple locations(260)
Protein-related
information
ResourceIDDescription
InterPro IPR024715 Coagulation factor 5/8
InterPro IPR000421 Coagulation factor 5/8 C-terminal type domain
InterPro IPR014707 Coagulation factor 8
InterPro IPR008972 Cupredoxin
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR002355 Multicopper oxidase, copper-binding site
InterPro IPR001117 Multicopper oxidase, type 1
InterPro IPR011706 Multicopper oxidase, type 2
InterPro IPR011707 Multicopper oxidase, type 3
Protein Ontology PR:000007302 coagulation factor VIII
References
(Earliest) J:9258 Amar LC, et al., Conservation and reorganization of loci on the mammalian X chromosome: a molecular framework for the identification of homologous subchromosomal regions in man and mouse. Genomics. 1988 Apr;2(3):220-30
(Latest) J:212401 Fahs SA, et al., A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII. Blood. 2014 Jun 12;123(24):3706-13
All references(117)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-1949, MGD-MRK-1955

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory