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F8
Gene Detail
Symbol

Name
ID
F8
coagulation factor VIII
MGI:88383
Synonyms
Cf8, Cf-8, Factor VIII, FVIII
Feature Type
protein coding gene
Genetic Map
Chromosome X
38.17 cM, cytoband A7-B
Detailed Genetic Map ± 1 cM


Mapping data(28)
Sequence Map
ChrX:75172715-75382615 bp, - strand
From VEGA annotation of GRCm38

  209901 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49153  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: F8
Protein SuperFamily: coagulation factor V/coagulation factor VIII
Gene Tree: F8

Human
homologs
F8, coagulation factor VIII, procoagulant component
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2157
neXtProt AC: NX_P00451

Human Synonyms: AHF, DXS1253E, F8B, F8C, FVIII, HEMA

Human Chr (Location): Xq28; chrX:154835788-155026934 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(5) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Male hemizygotes and female homozygotes for targeted null mutations produce no factor VIII, but are apparently healthy and fertile. However, affected mice show prolonged, exsanguinating bleeding following tail-clipping.
 
Human Diseases Modeled in Mice Using F8 (1)    Mutations Annotated to Human Diseases (3)   
Interactions
F8 interacts with 116 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process acute-phase response, blood coagulation, ...
Component extracellular region, extracellular space
Function copper ion binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (66)    Tissues (59)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 1
RT-PCR 55
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(1) cDNA(19) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000020850 (Evidence)
Ensembl Gene Model ENSMUSG00000031196 (Evidence)
Entrez Gene 14069 (Evidence)
UniGene 1805
DFCI TC1670043, TC1586398
DoTS DT.40185534
NIA Mouse Gene Index U039478
Consensus CDS Project CCDS30238.1, CCDS53114.1
International Mouse Phenotyping Consortium Status F8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020850 VEGA Gene Model | MGI Sequence Detail 209901 C57BL/6J ±  kb
transcript OTTMUST00000049293 VEGA | MGI Sequence Detail 9784 Not Applicable 
polypeptide OTTMUSP00000022815 VEGA | MGI Sequence Detail 2319 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(14) UniProt(7)
Polymorphisms
RFLP(4) : SNPs within 2kb(256 from dbSNP Build 137)    SNPs within 2kb including multiple locations(260)
Protein-related
information
ResourceIDDescription
InterPro IPR024715 Coagulation factor 5/8
InterPro IPR000421 Coagulation factor 5/8 C-terminal type domain
InterPro IPR014707 Coagulation factor 8
InterPro IPR008972 Cupredoxin
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR002355 Multicopper oxidase, copper-binding site
InterPro IPR001117 Multicopper oxidase, type 1
InterPro IPR011706 Multicopper oxidase, type 2
InterPro IPR011707 Multicopper oxidase, type 3
Protein Ontology PR:000007302 coagulation factor VIII
References
(Earliest) J:9258 Amar LC, et al., Conservation and reorganization of loci on the mammalian X chromosome: a molecular framework for the identification of homologous subchromosomal regions in man and mouse. Genomics. 1988 Apr;2(3):220-30
(Latest) J:220788 Leong L, et al., Noncovalent stabilization of the factor VIII A2 domain enhances efficacy in hemophilia A mouse vascular injury models. Blood. 2015 Jan 8;125(2):392-8
All references(118)
Disease annotation references (5)
Other
accession IDs
MGD-MRK-1949, MGD-MRK-1955

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory