F8
Gene Detail

Symbol Name ID

F8 coagulation factor VIII MGI:88383

Synonyms

Cf8, Cf-8, Factor VIII, FVIII

Feature Type

protein coding gene

Genetic Map

Chromosome X

38.17 cM, cytoband A7-B
Detailed Genetic Map ± 1 cM


Mapping data(29)

Sequence Map

ChrX:75172715-75382615 bp, - strand From VEGA annotation of GRCm38   209901 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49153  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: coagulation factor V/coagulation factor VIII
Gene Tree: F8

Human homologs

Human Homolog		F8, coagulation factor VIII, procoagulant component
NCBI Gene ID		2157
neXtProt AC		NX_P00451
Human Synonyms		AHF, DXS1253E, F8B, F8C, FVIII, HEMA
Human Chr (Location)		Xq28; chrX:154064063-154250998 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Male hemizygotes and female homozygotes for targeted null mutations produce no factor VIII, but are apparently healthy and fertile. However, affected mice show prolonged, exsanguinating bleeding following tail-clipping.

 
Human Diseases Modeled Using Mouse F8 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	acute-phase response, blood coagulation, ...
Component	extracellular region, extracellular space
Function	copper ion binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (58)    Tissues (54)    Images (4)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	1
RT-PCR	55

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(1) cDNA(19) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000020850 (Evidence)
Ensembl Gene Model	ENSMUSG00000031196 (Evidence)
Entrez Gene	14069 (Evidence)
UniGene	1805
DFCI	TC1586398, TC1670043
DoTS	DT.40185534
NIA Mouse Gene Index	U039478
Consensus CDS Project	CCDS30238.1, CCDS53114.1
International Mouse Knockout Project Status	F8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020850	VEGA Gene Model | MGI Sequence Detail	209901	C57BL/6J
transcript	OTTMUST00000049293	VEGA | MGI Sequence Detail	9784	Not Applicable
polypeptide	OTTMUSP00000022815	VEGA | MGI Sequence Detail	2319	Not Applicable

All sequences(40) RefSeq(6) UniProt(7)

Polymorphisms

RFLP(4) : SNPs(205 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024715	Coagulation factor 5/8
InterPro	IPR000421	Coagulation factor 5/8 C-terminal type domain
InterPro	IPR014707	Coagulation factor 8
InterPro	IPR008972	Cupredoxin
InterPro	IPR008979	Galactose-binding domain-like
InterPro	IPR002355	Multicopper oxidase, copper-binding site
InterPro	IPR001117	Multicopper oxidase, type 1
InterPro	IPR011706	Multicopper oxidase, type 2
InterPro	IPR011707	Multicopper oxidase, type 3
Protein Ontology	PR:000007302	coagulation factor VIII

References

(Earliest) J:9258 Amar LC, et al., Conservation and reorganization of loci on the mammalian X chromosome: a molecular framework for the identification of homologous subchromosomal regions in man and mouse. Genomics. 1988 Apr;2(3):220-30
(Latest) J:191310 Meeks SL, et al., A major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function. Blood. 2012 Sep 20;120(12):2512-20
All references(109)

Other accession IDs

MGD-MRK-1949, MGD-MRK-1955