Phenotypes Associated with This Genotype

Genotype
MGI:8213044

• Allelic Composition: F8^tm1.1Len/Y
• Genetic Background: B6.Cg-F8^tm1.1Len

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:266699 )

♂ • fewer pups (70.9%) survive until weaning compared to F8^tm1Kaz mice (93.2%)

homeostasis/metabolism

impaired blood coagulation ( J:266699 )

♂ • mice exhibit extensive blood loss following tail-snip; blood loss is similar to F8^tm1Kaz mice

♂ • infusion with human factor VIII corrects the bleeding phenotype

immune system

abnormal immune tolerance ( J:266699 )

♂ • mice develop anti-factor VIII antibodies following administration of factor VIII

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
factor VIII deficiency		DOID:12134	OMIM:306700	J:266699