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Bmi1 Gene Detail
Summary
  • Symbol
    Bmi1
  • Name
    Bmi1 proto-oncogene, polycomb ring finger
  • Synonyms
    Bmi-1, Bmi1, Pcgf4
  • Feature Type
    protein coding gene
  • IDs
    MGI:88174
    NCBI Gene: 12151
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:18681953-18691440 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 12.90 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    166 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88174
 protein coding gene Chr2:18681829-18691440 (+)
129S1/SvImJ ENSMUSG00200041802
 protein coding gene Chr2:15635727-15645338 (+)
A/J ENSMUSG00195016016
 protein coding gene Chr2:15713770-15723382 (+)
AKR/J ENSMUSG00220013483
 protein coding gene Chr2:15706801-15716414 (+)
BALB/cJ ENSMUSG00180036176
 protein coding gene Chr2:15757092-15766703 (+)
C3H/HeJ ENSMUSG00175021318
 protein coding gene Chr2:15718275-15727886 (+)
C57BL/6NJ ENSMUSG00215030519
 protein coding gene Chr2:15807459-15817070 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023207
 protein coding gene Chr2:15119888-15129427 (+)
CAST/EiJ ENSTCUG00005004297
 protein coding gene Chr2:15567426-15577016 (+)
CBA/J ENSMUSG00210003551
 protein coding gene Chr2:15756270-15765881 (+)
DBA/2J ENSMUSG00185037619
 protein coding gene Chr2:15655912-15665524 (+)
FVB/NJ ENSMUSG00205011939
 protein coding gene Chr2:15710622-15720233 (+)
JF1/MsJ ENSUMUG00000003004
 protein coding gene Chr2:15633602-15643221 (+)
LP/J ENSMUSG00230015616
 protein coding gene Chr2:17594005-17603616 (+)
NOD/ShiLtJ ENSMUSG00190014436
 protein coding gene Chr2:15725455-15735067 (+)
NZO/HlLtJ ENSMUSG00225001302
 protein coding gene Chr2:25344573-25354184 (+)
PWK/PhJ ENSLUMG00010031305
 protein coding gene Chr2:15739733-15749345 (+)
SPRET/EiJ ENSMSPG00010014511
 protein coding gene Chr2:16182569-16192159 (+)
WSB/EiJ ENSIUOG00005015076
 protein coding gene Chr2:15801537-15811147 (+)



Homology
more
  • Human Ortholog
    BMI1, BMI1 proto-oncogene, polycomb ring finger
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BMI1, BMI1 proto-oncogene, polycomb ring finger
  • Synonyms
    flvi-2/bmi-1, FLVI2/BMI1, PCGF4, RNF51
  • Links
    NCBI Gene ID: 648
    UniProt: P35226

  • Chr Location
    10p12.2; chr10:22321078-22331706 (+)  GRCh38
  • Human Ortholog
    COMMD3-BMI1, COMMD3-BMI1 readthrough
  • Synonyms
    PCGF4, RNF51
  • Links
    NCBI Gene ID: 100532731

  • Chr Location
    chr10:22316388-22331484 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human BMI1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    119 phenotypes from 6 alleles in 9 genetic backgrounds
    67 phenotypes from multigenic genotypes
    184 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants display severe hematopoietic defects, neurological abnormalities, posterior transformation, and infertility in both sexes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    84
  • GO References
    29
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1364
  • Tissues
    389
  • cDNA Data
    142
  • Literature Summary
    68
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12151 NCBI Gene Model | MGI Sequence Detail 9488 C57BL/6J ±  kb
    transcript NM_007552 RefSeq | MGI Sequence Detail 3470 C57BL/6  
    polypeptide P25916 UniProt | EBI | MGI Sequence Detail 324 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 160
      Genomic 6
      cDNA 143
      Primer pair 7
      Other 4
      Antibodies 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1588, MGD-MRK-1589, MGI:2139375
    References
    more
    • Summaries
      All 384
      Developmental Gene Expression 68
      Gene Ontology 29
      Phenotypes 184
    • Earliest
      J:11213 van Lohuizen M, et al., Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging [see comments]. Cell. 1991 May 31;65(5):737-52
    • Latest
      J:385379 Baquero J, et al., Key Early Changes in Oral Squamous Cell Carcinogenesis Are Accelerated by Ectopic BMI1 Expression. Cancer Res Commun. 2026 Jan 1;6(1):152-164
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/08/2026
    MGI 6.24     		The Jackson Laboratory