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Bmi1
Gene Detail
Symbol

Name
ID
Bmi1
Bmi1 polycomb ring finger oncogene
MGI:88174
Synonyms
Bmi1, Bmi-1, Pcgf4
Feature Type
protein coding gene
Genetic Map
Chromosome 2
12.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr2:18677018-18686629 bp, + strand
From VEGA annotation of GRCm38

  9612 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3797  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BMI1, COMMD3-BMI1
Gene Tree: Bmi1

Human
homologs
BMI1, BMI1 proto-oncogene, polycomb ring finger
Orthology source: HGNC

IDs:
NCBI Gene ID: 648
neXtProt AC: NX_P35226

Human Synonyms: FLVI2/BMI1, PCGF4, RNF51

Human Chr (Location): 10p11.23; chr10:22321210-22331485 (+)  GRCh38.p2

  1 More Homolog(s):
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants display decreased hematopoietic cell number, immune deficiency, neurological abnormalities, and posterior transformation, while transgenic overexpressing mice show an opposite dose-dependent anterior transformation of vertebral identity.
 
Interactions
Bmi1 interacts with 308 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process brain development, cellular process, ...
Component cytoplasm, heterochromatin, ...
Function chromatin binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (50 records)
Data Summary: Results (545)    Tissues (321)    Images (85)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 16
RNA in situ 450
Northern blot 13
Western blot 28
RT-PCR 38
cDNA source data(140)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase bmi1 ; ZFIN bmi1a    NEW 
Molecular
reagents
All nucleic(150) Genomic(6) cDNA(141) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000011429 (Evidence)
Ensembl Gene Model ENSMUSG00000026739 (Evidence)
Entrez Gene 12151 (Evidence)
UniGene 289584
DoTS DT.536201, DT.97371067
PDB 2CKL
Consensus CDS Project CCDS15711.1
International Mouse Phenotyping Consortium Status Bmi1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011429 VEGA Gene Model | MGI Sequence Detail 9612 C57BL/6J ±  kb
transcript OTTMUST00000026762 VEGA | MGI Sequence Detail 3594 Not Applicable 
polypeptide OTTMUSP00000012215 VEGA | MGI Sequence Detail 324 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(8) UniProt(7)
Polymorphisms
RFLP(4) : SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018957 Zinc finger, C3HC4 RING-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000004770 polycomb complex protein BMI-1
References
(Earliest) J:11213 van Lohuizen M, et al., Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging [see comments]. Cell. 1991 May 31;65(5):737-52
(Latest) J:221894 Gonzalez-Valdes I, et al., Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence. Nat Commun. 2015;6:6473
All references(175)
Other
accession IDs
MGD-MRK-1588, MGD-MRK-1589, MGI:2139375

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory