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Bmi1 Gene Detail
Summary
  • Symbol
    Bmi1
  • Name
    Bmi1 polycomb ring finger oncogene
  • Synonyms
    Bmi1, Bmi-1, Pcgf4
  • Feature Type
    protein coding gene
  • IDs
    MGI:88174
    NCBI Gene: 12151
  • Gene Overview
    MyGene.info: BMI1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:18677018-18686629 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9612 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 12.90 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    BMI1, BMI1 proto-oncogene, polycomb ring finger
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BMI1, BMI1 proto-oncogene, polycomb ring finger
    Orthology source: HGNC
  • Synonyms
    flvi-2/bmi-1, FLVI2/BMI1, PCGF4, RNF51
  • Links
    NCBI Gene ID: 648
    neXtProt AC: NX_P35226
    UniProt: P35226

  • Chr Location
    10p12.2; chr10:22321210-22331485 (+)  GRCh38.p7

  • Human Ortholog
    COMMD3-BMI1, COMMD3-BMI1 readthrough
    Orthology source: HomoloGene
  • Synonyms
    BMI1, PCGF4, RNF51
  • Links
    NCBI Gene ID: 100532731
    neXtProt AC: NX_P35226

  • Chr Location
    chr10:22316383-22331485 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    67 phenotypes from 6 alleles in 7 genetic backgrounds
    66 phenotypes from multigenic genotypes
    108 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants display decreased hematopoietic cell number, immune deficiency, neurological abnormalities, and posterior transformation, while transgenic overexpressing mice show an opposite dose-dependent anterior transformation of vertebral identity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000011429 VEGA Gene Model | MGI Sequence Detail 9612 C57BL/6J ±  kb
    transcript OTTMUST00000026762 VEGA | MGI Sequence Detail 3594 Not Applicable  
    polypeptide OTTMUSP00000012215 VEGA | MGI Sequence Detail 324 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      9 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 154
      Genomic 6
      cDNA 143
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
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    MGD-MRK-1588, MGD-MRK-1589, MGI:2139375
    References
    more
    • Summaries
      All 237
      Developmental Gene Expression 57
      Gene Ontology 26
      Phenotypes 108
    • Earliest
      J:11213 van Lohuizen M, et al., Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging [see comments]. Cell. 1991 May 31;65(5):737-52
    • Latest
      J:263866 Kim MJ, et al., PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis. Dev Cell. 2018 Mar 12;44(5):582-596.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory