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Bmi1
Gene Detail
Symbol

Name
ID
Bmi1
Bmi1 polycomb ring finger oncogene
MGI:88174
Synonyms
Bmi1, Bmi-1, Pcgf4
Feature Type
protein coding gene
Genetic Map
Chromosome 2
12.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr2:18677018-18686629 bp, + strand
From VEGA annotation of GRCm38

  9612 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3797  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Bmi1

Human
homologs
Human Homolog COMMD3-BMI1, COMMD3-BMI1 readthrough
NCBI Gene ID 100532731
neXtProt AC  NX_P35226
Human Chr (Location)  chr10:22316383-22331485 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants display decreased hematopoietic cell number, immune deficiency, neurological abnormalities, and posterior transformation, while transgenic overexpressing mice show an opposite dose-dependent anterior transformation of vertebral identity.
 
Interactions
Bmi1 interacts with 308 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process brain development, cellular process, ...
Component cytoplasm, heterochromatin, ...
Function chromatin binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (45 records)
Data Summary: Results (545)    Tissues (321)    Images (85)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 16
RNA in situ 450
Northern blot 13
Western blot 28
RT-PCR 38
cDNA source data(140)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(150) Genomic(6) cDNA(141) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000011429 (Evidence)
Ensembl Gene ModelENSMUSG00000026739 (Evidence)
Entrez Gene12151 (Evidence)
UniGene289584
DoTSDT.536201, DT.97371067
PDB2CKL
Consensus CDS ProjectCCDS15711.1
International Mouse Knockout Project StatusBmi1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011429 VEGA Gene Model | MGI Sequence Detail 9612 C57BL/6J ±  kb
transcript OTTMUST00000026762 VEGA | MGI Sequence Detail 3594 Not Applicable 
polypeptide OTTMUSP00000012215 VEGA | MGI Sequence Detail 324 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(6) UniProt(7)
Polymorphisms
RFLP(4) : SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018957 Zinc finger, C3HC4 RING-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000004770 polycomb complex protein BMI-1
References
(Earliest) J:11213 van Lohuizen M, et al., Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging [see comments]. Cell. 1991 May 31;65(5):737-52
(Latest) J:210467 Kang E, et al., Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos. Nature. 2014 May 1;509(7498):101-4
All references(164)
Other
accession IDs
MGD-MRK-1588, MGD-MRK-1589, MGI:2139375

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory