Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; promoter-specific chromatin binding activity; and ubiquitin-protein transferase activator activity. Involved in positive regulation of B cell proliferation and positive regulation of immature T cell proliferation in thymus. Acts upstream of or within several processes, including chordate embryonic development; negative regulation of macromolecule biosynthetic process; and regulation of adaxial/abaxial pattern formation. Located in nuclear body. Part of PRC1 complex and heterochromatin. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; hepatocellular carcinoma; and renal Wilms' tumor. Orthologous to human BMI1 (BMI1 proto-oncogene, polycomb ring finger) and COMMD3-BMI1 (COMMD3-BMI1 readthrough).