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Bcl2l1
Gene Detail
 Symbol
Name
ID
Bcl2l1
BCL2-like 1
MGI:88139
Synonyms bcl-x, BclX, Bcl-XL, Bcl(X)L, Bcl-Xs
Feature Type protein coding gene
Genetic Map
Chromosome 2
75.41 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:152780668-152831728 bp, - strand
From VEGA annotation of GRCm38

  51061 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7639  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: apoptosis regulator, Bcl2 type
Gene Tree: Bcl2l1

Human
homologs
Human Homolog BCL2L1, BCL2-like 1
NCBI Gene ID 598
neXtProt AC  NX_Q07817
Human Synonyms  BCL2L, Bcl-X, BCLX, bcl-xL, BCLXL, BCL-XL/S, bcl-xS, BCLXS, PPP1R52
Human Chr (Location)  20q11.21; chr20:31664452-31723955 (-)  GRCh38
Alleles
and
phenotypes
All alleles(174) : Chemically induced (ENU)(2) Gene trapped(165) Targeted(7)
 
Homozygous null mutants die at embryonic day 13 with extensive apoptotic cell death, hypomorphic mutants have severe reproductive defects due to abnormal germ cell development. Mice lacking the gamma isoform show immune defects.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (96 annotations)
Process apoptotic process, apoptotic process in bone marrow, ...
Component Bcl-2 family protein complex, cell junction, ...
Function BH3 domain binding, BH domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (55 records)
Data Summary: Results (232)    Tissues (100)    Images (18)
Theiler Stages: 1, 2, 3, 4, 5, 13, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 24
Northern blot 54
Western blot 39
RT-PCR 87
RNase protection 5
Nuclease S1 19
cDNA source data(117)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(128) Genomic(3) cDNA(117) Primer pair(7) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000015815 (Evidence)
Ensembl Gene ModelENSMUSG00000007659 (Evidence)
Entrez Gene12048 (Evidence)
UniGene238213
DFCITC1574329, TC1592505, TC1593792, TC1596533, TC1660699, TC1722969
DoTSDT.101403398, DT.101403401, DT.40137844, DT.488390, DT.94365433, DT.94365435, DT.97388779
NIA Mouse Gene IndexU023508
PDB2BZW, 3IHC, 3IHD, 3IHE, 3IHF, 3IIG, 3IIH, 3ILB, 3ILC, 1PQ0, 1PQ1
Consensus CDS ProjectCCDS16899.1
International Mouse Knockout Project StatusBcl2l1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015815 VEGA Gene Model | MGI Sequence Detail 51061 C57BL/6J ±  kb
transcript OTTMUST00000037600 VEGA | MGI Sequence Detail 2417 Not Applicable 
polypeptide OTTMUSP00000016850 VEGA | MGI Sequence Detail 233 Not Applicable 

For the selected sequences
All sequences(100) RefSeq(15) UniProt(8)
Polymorphisms RFLP(3) : SNPs within 2kb(222 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004725 Apoptosis regulator, Bcl-2/ BclX
InterPro IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved site
InterPro IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved site
InterPro IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved site
InterPro IPR020731 Apoptosis regulator, Bcl-2, BH4 motif, conserved site
InterPro IPR003093 Apoptosis regulator, Bcl-2 protein, BH4
InterPro IPR013279 Apoptosis regulator, Bcl-X
InterPro IPR002475 Bcl2-like
InterPro IPR026298 Blc2 family
Protein Ontology PR:000002308 Bcl-2-like protein 1
References (Earliest) J:17687 Swendeman SL, et al., Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2. J Biol Chem. 1994 Apr 15;269(15):11663-71
(Latest) J:206385 Okamoto T, et al., Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):261-6
All references(233)
Other
accession IDs
MGD-MRK-1527

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory