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Bcl2l1 Gene Detail
Summary
  • Symbol
    Bcl2l1
  • Name
    BCL2-like 1
  • Synonyms
    bcl-x, BclX, Bcl-XL, Bcl(X)L, Bcl-Xs
  • Feature Type
    protein coding gene
  • IDs
    MGI:88139
    NCBI Gene: 12048
  • Gene Overview
    MyGene.info: BCL2L1
Location & Maps
more
  • Sequence Map
    Chr2:152780668-152831728 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51061 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 75.41 cM, cytoband H1
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    BCL2L1, BCL2 like 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BCL2L1, BCL2 like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCL2L, Bcl-X, BCLX, BCL-XL/S, PPP1R52
  • Links
    NCBI Gene ID: 598
    neXtProt AC: NX_Q07817

  • Chr Location
    20q11.21; chr20:31664452-31723964 (-)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 9 alleles in 10 genetic backgrounds
    29 phenotypes from multigenic genotypes
    114 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    184
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Gene trapped
    165
  • Radiation induced
    1
  • Targeted
    7
  • Transgenic
    8
  • Genomic Mutations
    2 involving Bcl2l1
Homozygous null mutants die at embryonic day 13 with extensive apoptotic cell death, hypomorphic mutants have severe reproductive defects due to abnormal germ cell development. Mice lacking the gamma isoform show immune defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015815 VEGA Gene Model | MGI Sequence Detail 51061 C57BL/6J ±  kb
transcript OTTMUST00000037600 VEGA | MGI Sequence Detail 2417 Not Applicable  
polypeptide OTTMUSP00000016850 VEGA | MGI Sequence Detail 233 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    400 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 128
    Genomic 3
    cDNA 117
    Primer pair 7
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-1527
References
more
  • Summaries
    All 235
    Developmental Gene Expression 56
    Diseases 1
    Gene Ontology 39
    Phenotypes 114
  • Earliest
    J:17687 Swendeman SL, et al., Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2. J Biol Chem. 1994 Apr 15;269(15):11663-71
  • Latest
    J:235886 Choi S, et al., Bcl-xL promotes metastasis independent of its anti-apoptotic activity. Nat Commun. 2016 Jan 20;7:10384

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory