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Bcl2l1 Gene Detail
Summary
  • Symbol
    Bcl2l1
  • Name
    BCL2-like 1
  • Synonyms
    bcl-x, BclX, Bcl-XL, Bcl(X)L, Bcl-Xs
  • Feature Type
    protein coding gene
  • IDs
    MGI:88139
    NCBI Gene: 12048
  • Gene Overview
    MyGene.info: BCL2L1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:152780668-152831728 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51061 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 75.41 cM, cytoband H1
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    BCL2L1, BCL2 like 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BCL2L1, BCL2 like 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BCL2L, Bcl-X, BCLX, BCL-XL/S, PPP1R52
  • Links
    NCBI Gene ID: 598
    neXtProt AC: NX_Q07817
    UniProt: Q07817

  • Chr Location
    20q11.21; chr20:31664452-31723999 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 9 alleles in 10 genetic backgrounds
    29 phenotypes from multigenic genotypes
    116 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants die at embryonic day 13 with extensive apoptotic cell death, hypomorphic mutants have severe reproductive defects due to abnormal germ cell development. Mice lacking the gamma isoform show immune defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000015815 VEGA Gene Model | MGI Sequence Detail 51061 C57BL/6J ±  kb
    transcript OTTMUST00000037600 VEGA | MGI Sequence Detail 2417 Not Applicable  
    polypeptide OTTMUSP00000016850 VEGA | MGI Sequence Detail 233 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      400 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 129
      Genomic 3
      cDNA 118
      Primer pair 7
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-1527
    References
    more
    • Summaries
      All 325
      Developmental Gene Expression 59
      Diseases 1
      Gene Ontology 39
      Phenotypes 116
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:249423 Barrott JJ, et al., The Influential Role of BCL2 Family Members in Synovial Sarcomagenesis. Mol Cancer Res. 2017 Dec;15(12):1733-1740

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory