About   Help   FAQ
Bcl2l1
Gene Detail
Symbol

Name
ID
Bcl2l1
BCL2-like 1
MGI:88139
Synonyms
bcl-x, BclX, Bcl-XL, Bcl(X)L, Bcl-Xs
Feature Type
protein coding gene
Genetic Map
Chromosome 2
75.41 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:152780668-152831728 bp, - strand
From VEGA annotation of GRCm38

  51061 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7639  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: BCL2L1
Protein SuperFamily: apoptosis regulator, Bcl2 type
Gene Tree: Bcl2l1

Human
homologs
BCL2L1, BCL2-like 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 598
neXtProt AC: NX_Q07817

Human Synonyms: BCL2L, Bcl-X, BCLX, bcl-xL, BCLXL, BCL-XL/S, bcl-xS, BCLXS, PPP1R52

Human Chr (Location): 20q11.21; chr20:31664452-31723964 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(175) : Chemically induced (ENU)(2) Gene trapped(165) Targeted(7) Transgenic(1)
 
Homozygous null mutants die at embryonic day 13 with extensive apoptotic cell death, hypomorphic mutants have severe reproductive defects due to abnormal germ cell development. Mice lacking the gamma isoform show immune defects.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Bcl2l1 interacts with 247 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (95 annotations)
Process apoptotic process, apoptotic process in bone marrow, ...
Component Bcl-2 family protein complex, cell junction, ...
Function BH3 domain binding, BH domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (55 records)
Data Summary: Results (212)    Tissues (99)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 24
Northern blot 41
Western blot 39
RT-PCR 80
RNase protection 5
Nuclease S1 19
cDNA source data(117)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase bcl2l1 ; ZFIN bcl2l1    NEW 
Molecular
reagents
All nucleic(128) Genomic(3) cDNA(117) Primer pair(7) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000015815 (Evidence)
Ensembl Gene Model ENSMUSG00000007659 (Evidence)
Entrez Gene 12048 (Evidence)
UniGene 238213
DFCI TC1574329, TC1592505, TC1593792, TC1596533, TC1660699, TC1722969
DoTS DT.101403398, DT.101403401, DT.40137844, DT.488390, DT.94365433, DT.94365435, DT.97388779
NIA Mouse Gene Index U023508
PDB 2BZW, 3IHC, 3IHD, 3IHE, 3IHF, 3IIG, 3IIH, 3ILB, 3ILC, 1PQ0, 1PQ1
Consensus CDS Project CCDS16899.1
International Mouse Phenotyping Consortium Status Bcl2l1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015815 VEGA Gene Model | MGI Sequence Detail 51061 C57BL/6J ±  kb
transcript OTTMUST00000037600 VEGA | MGI Sequence Detail 2417 Not Applicable 
polypeptide OTTMUSP00000016850 VEGA | MGI Sequence Detail 233 Not Applicable 

For the selected sequences
All sequences(102) RefSeq(17) UniProt(8)
Polymorphisms
RFLP(3) : SNPs within 2kb(222 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004725 Apoptosis regulator, Bcl-2/ BclX
InterPro IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved site
InterPro IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved site
InterPro IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved site
InterPro IPR020731 Apoptosis regulator, Bcl-2, BH4 motif, conserved site
InterPro IPR003093 Apoptosis regulator, Bcl-2 protein, BH4
InterPro IPR013279 Apoptosis regulator, Bcl-X
InterPro IPR002475 Bcl2-like
InterPro IPR026298 Blc2 family
Protein Ontology PR:000002308 Bcl-2-like protein 1
References
(Earliest) J:17687 Swendeman SL, et al., Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2. J Biol Chem. 1994 Apr 15;269(15):11663-71
(Latest) J:220777 Grabow S, et al., MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice. Blood. 2014 Dec 18;124(26):3939-46
All references(231)
Other
accession IDs
MGD-MRK-1527

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/30/2015
MGI 5.22
The Jackson Laboratory