Bcl2l1
Gene Detail

Symbol Name ID

Bcl2l1 BCL2-like 1 MGI:88139

Synonyms

bcl-x, BclX, Bcl-XL, Bcl(X)L, Bcl-Xs

Feature Type

protein coding gene

Genetic Map

Chromosome 2

75.41 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr2:152780668-152831728 bp, - strand From VEGA annotation of GRCm38   51061 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7639  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: apoptosis regulator, Bcl2 type
Gene Tree: Bcl2l1

Human homologs

Human Homolog		BCL2L1, BCL2-like 1
NCBI Gene ID		598
neXtProt AC		NX_Q07817
Human Synonyms		BCL2L, Bcl-X, BCLX, bcl-xL, BCLXL, BCL-XL/S, bcl-xS, BCLXS, PPP1R52
Human Chr (Location)		20q11.21; chr20:30252261-30310656 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(174) : Targeted(7) Gene trapped(165) Chemically induced(2)
 

Homozygous null mutants die at embryonic day 13 with extensive apoptotic cell death, hypomorphic mutants have severe reproductive defects due to abnormal germ cell development. Mice lacking the gamma isoform show immune defects.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (75 annotations)

Process	apoptotic process, apoptotic process in bone marrow, ...
Component	Bcl-2 family protein complex, centrosome, ...
Function	BH3 domain binding, BH domain binding, ...

External Resources: FuncBase

Expression

Literature Summary: (50 records)
Data Summary: Results (206)    Tissues (94)    Images (13)
Theiler Stages: 1, 2, 3, 4, 5, 13, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	24
Northern blot	40
Western blot	39
RT-PCR	77
RNase protection	5
Nuclease S1	19

cDNA source data(119)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(131) Genomic(3) cDNA(119) Primer pair(6) Other(3)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000015815 (Evidence)
Ensembl Gene Model	ENSMUSG00000007659 (Evidence)
Entrez Gene	12048 (Evidence)
UniGene	238213
DFCI	TC1574329, TC1592505, TC1593792, TC1596533, TC1722969
DoTS	DT.101403398, DT.101403401, DT.40137844, DT.488390, DT.94365433, DT.94365435, DT.97388779
NIA Mouse Gene Index	U023508
PDB	2BZW, 3IHC, 3IHD, 3IHE, 3IHF, 3IIG, 3IIH, 3ILB, 3ILC, 1PQ0, 1PQ1
Consensus CDS Project	CCDS16899.1
International Mouse Knockout Project Status	Bcl2l1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015815	VEGA Gene Model | MGI Sequence Detail	51061	C57BL/6J
transcript	OTTMUST00000037600	VEGA | MGI Sequence Detail	2417	Not Applicable
polypeptide	OTTMUSP00000016850	VEGA | MGI Sequence Detail	233	Not Applicable

All sequences(82) RefSeq(2) UniProt(8)

Polymorphisms

RFLP(3) : SNPs(195 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004725	Apoptosis regulator, Bcl-2/ BclX
InterPro	IPR020717	Apoptosis regulator, Bcl-2, BH1 motif, conserved site
InterPro	IPR020726	Apoptosis regulator, Bcl-2, BH2 motif, conserved site
InterPro	IPR020728	Apoptosis regulator, Bcl-2, BH3 motif, conserved site
InterPro	IPR020731	Apoptosis regulator, Bcl-2, BH4 motif, conserved site
InterPro	IPR003093	Apoptosis regulator, Bcl-2 protein, BH4
InterPro	IPR013279	Apoptosis regulator, Bcl-X
InterPro	IPR002475	Bcl2-like
InterPro	IPR026298	Blc2 family
Protein Ontology	PR:000002308	Bcl-2-like protein 1

References

(Earliest) J:17687 Swendeman SL, et al., Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2. J Biol Chem. 1994 Apr 15;269(15):11663-71
(Latest) J:193618 Peperzak V, et al., Mcl-1 is essential for the survival of plasma cells. Nat Immunol. 2013 Feb 3;14(3):290-7
All references(211)

Other accession IDs

MGD-MRK-1527