Bcl2l1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Bcl2l1
BCL2-like 1
MGI:88139

36 phenotypes from 9 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Bcl2l1^Plt16/Bcl2l1⁺ involves: BALB/c * C57BL/6	abnormal platelet physiology	J:149205
	increased megakaryocyte cell number	J:149205
	thrombocytopenia	J:149205
Bcl2l1^Plt16/Bcl2l1^Plt16 involves: BALB/c * C57BL/6	prenatal lethality, incomplete penetrance	J:149205
Bcl2l1^Plt20/Bcl2l1⁺ involves: BALB/c * C57BL/6	abnormal platelet physiology	J:149205
	increased megakaryocyte cell number	J:149205
	thrombocytopenia	J:149205
Bcl2l1^Plt20/Bcl2l1^Plt16 involves: BALB/c * C57BL/6	thrombocytopenia	J:149205
Bcl2l1^Plt20/Bcl2l1^Plt20 involves: BALB/c * C57BL/6	abnormal platelet physiology	J:149205
	extramedullary hematopoiesis	J:149205
	increased megakaryocyte cell number	J:149205
	thrombocytopenia	J:149205
Bcl2l1^tm1.1Mam/Bcl2l1^tm1.1Mam 7630403G23Rik^{Tg(Th-cre)1Tmd}/? involves: 129S6/SvEvTac * C57BL/6 * SJL	abnormal locus ceruleus morphology	J:99848
	abnormal motor capabilities/coordination/movement	J:99848
	decreased body weight	J:99848
	decreased brain weight	J:99848
	decreased dopamine level	J:99848
	decreased substantia nigra size	J:99848
Bcl2l1^tm1Cant/Bcl2l1^tm1Cant involves: 129S6/SvEvTac	abnormal memory T cell physiology	J:77507
	abnormal T cell physiology	J:77507
	decreased interleukin-2 secretion	J:77507
	decreased memory T cell number	J:77507
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:77507
	decreased T cell proliferation	J:77507
Bcl2l1^tm1Dlo/Bcl2l1⁺ B6.Cg-Bcl2l1^tm1Dlo	abnormal platelet physiology	J:149205
Bcl2l1^tm1Dlo/Bcl2l1⁺ B6.Cg-Bcl2l1^tm1Dlo	thrombocytopenia	J:149205
Bcl2l1^tm1Dlo/Bcl2l1^Plt20 involves: BALB/c * C57BL/6	thrombocytopenia	J:149205
Bcl2l1^tm1Dlo/Bcl2l1^tm1.1Mam Tg(Aicda-cre)9Mbu/0 B6.Cg-Bcl2l1^tm1Dlo/Bcl2l1^tm1.1Mam Tg(Aicda-cre)9Mbu	decreased IgG1 level	J:166069
	normal immune system phenotype	J:166069
Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo Not Specified	increased apoptosis	J:39573
Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo Not Specified	increased neuron apoptosis	J:39573
Bcl2l1^tm1Mam/Bcl2l1^tm1Mam involves: 129S6/SvEvTac * C57BL/6	abnormal apoptosis	J:63161
	decreased litter size	J:63161
	decreased primordial germ cell number	J:63161
	decreased primordial ovarian follicle number	J:63161
	male infertility	J:63161
	reduced female fertility	J:63161
	small testis	J:63161
Bcl2l1^tm1Tak/Bcl2l1^tm1Tak Tg(KRT5-cre)1Tak/0 involves: C3H * C57BL/6	decreased keratinocyte adhesion	J:82661
	increased cellular sensitivity to ultraviolet irradiation	J:82661
	increased keratinocyte apoptosis	J:82661
Bcl2l1^tm1Ywh/Bcl2l1^tm1Ywh Tg(Lck-cre)548Jxm/? involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA	decreased double-positive T cell number	J:99012
	decreased thymocyte number	J:99012
Tg(Lck-Bcl2l1)1Cant/? B6.Cg-Tg(Lck-Bcl2l1)1Cant	increased interleukin-2 secretion	J:77507
	increased memory T cell number	J:77507
	increased T cell proliferation	J:77507

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23