Bcl2l1^tm1Tak
Targeted Allele Detail

Summary

• Symbol: Bcl2l1^tm1Tak
• Name: BCL2-like 1; targeted mutation 1, Junji Takeda
• MGI ID: MGI:2654939
• Synonyms: Bcl-x^flox
• Gene: Bcl2l1 Location: Chr2:152622588-152673648 bp, - strand Genetic Position: Chr2, 75.41 cM, cytoband H1
• Alliance: Bcl2l1^tm1Tak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82661
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was introduced upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 2 via homologous recombination. The floxed neo cassette was subsequently removed by mating mutant animals to cre deleter strain TgN(EIIa-cre)C5379Lmgd, resulting in animals carrying floxed exon 1-2 alleles. (J:82661)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl2l1 Mutation: 108 strains or lines available

References

• Original: J:82661 Umeda J, et al., In vivo cooperation between Bcl-xL and the phosphoinositide 3-kinase-Akt signaling pathway for the protection of epidermal keratinocytes from apoptosis. FASEB J. 2003 Apr;17(6):610-20
• All: 2 reference(s)