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B2m
Gene Detail
Symbol

Name
ID
B2m
beta-2 microglobulin
MGI:88127
Synonyms
beta2-m, beta 2 microglobulin, Ly-m11
Feature Type
protein coding gene
Genetic Map
Chromosome 2
60.55 cM, cytoband F1-F3
Detailed Genetic Map ± 1 cM


Mapping data(125)
Sequence Map
Chr2:122147686-122153083 bp, + strand
From VEGA annotation of GRCm38

  5398 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2987  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: B2M
Gene Tree: B2m

Human
homologs
B2M, beta-2-microglobulin
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 567
neXtProt AC: NX_P61769

Human Chr (Location): 15q21.1; chr15:44711487-44718159 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human B2M

Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(26) Targeted(5) Transgenic(7)
 
Homozygotes lacking B2m appear normal, but have no detectable MHC class I antigen on their cells and are deficient in CD4- CD8+ T cells which mediate cytotoxic T cell function. Mutant mice are also subject to systemic iron loading.
 
Mutations Annotated to Human Diseases (2)   
Interactions
B2m interacts with 93 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Expression
Literature Summary: (18 records)
Data Summary: Results (35)    Tissues (26)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RT-PCR 10
RNase protection 20
cDNA source data(21)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase b2m ; ZFIN b2m    NEW 
Molecular
reagents
All nucleic(57) Genomic(27) cDNA(21) Primer pair(5) Other(4)
Microarray probesets(5)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015534 VEGA Gene Model | MGI Sequence Detail 5398 C57BL/6J ±  kb
transcript OTTMUST00000036889 VEGA | MGI Sequence Detail 860 Not Applicable 
polypeptide OTTMUSP00000016550 VEGA | MGI Sequence Detail 119 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(3)
Polymorphisms
All PCR and RFLP(23) : PCR(2) RFLP(21) SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
Protein Ontology PR:000004580 beta-2-microglobulin
References
(Earliest) J:1872 Tada N, et al., Ly-m11: the H-3 region of mouse chromosome 2 controls a new surface alloantigen. Immunogenetics. 1980;11(5):441-9
(Latest) J:220394 Tzelepis F, et al., Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection. J Clin Invest. 2015 Feb;125(2):752-68
All references(793)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-12010, MGD-MRK-1492

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory