About   Help   FAQ
B2m
Gene Detail
 Symbol
Name
ID
B2m
beta-2 microglobulin
MGI:88127
Synonyms beta2-m, beta 2 microglobulin, Ly-m11
Feature Type protein coding gene
Genetic Map
Chromosome 2
60.55 cM, cytoband F1-F3
Detailed Genetic Map ± 1 cM


Mapping data(125)
Sequence Map
Chr2:122147686-122153083 bp, + strand
From VEGA annotation of GRCm38

  5398 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2987  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: B2m

Human
homologs
Human Homolog B2M, beta-2-microglobulin
NCBI Gene ID 567
neXtProt AC  NX_P61769
Human Chr (Location)  15q21-q22.2; chr15:44711487-44718159 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human B2M
Alleles
and
phenotypes
All alleles(31) : Targeted(5) Gene trapped(26)
 
Homozygotes lacking B2m appear normal, but have no detectable MHC class I antigen on their cells and are deficient in CD4- CD8+ T cells which mediate cytotoxic T cell function. Mutant mice are also subject to systemic iron loading.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent, antigen processing and presentation of peptide antigen via MHC class I, ...
Component cytoplasm, external side of plasma membrane, ...
Function identical protein binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (38)    Tissues (27)   
Theiler Stages: 1, 2, 3, 4, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 5
RT-PCR 13
RNase protection 20
cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(57) Genomic(27) cDNA(21) Primer pair(5) Other(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000015534 (Evidence)
Ensembl Gene ModelENSMUSG00000060802 (Evidence)
Entrez Gene12010 (Evidence)
NIA Mouse Gene IndexU002368
PDB1BII, 1BQH, 1DDH, 1FFN, 1FFO, 1FFP, 1FZJ, 1FZK, 1FZM, 1FZO, 1G6R, 1G7P, 1G7Q, 1HOC, 1INQ, 1JPF, 1JPG, 1JUF, 1K8D, 1KBG, 1KPU, 1KPV, 1L6Q, 1LDP, 1LEG, 1LEK, 1MHC, 1MWA, 1N3N, 1N5A, 1NAM, 1NAN, 1NEZ, 1OSZ, 1P1Z, 1P4L, 1PQZ, 1RJY, 1RJZ, 1S7Q, 1S7R, 1S7S, 1S7T, 1S7U, 1S7V, 1S7W, 1S7X, 1T0M, 1T0N, 1VAC, 1VAD, 1WBX, 1WBY, 1WBZ, 1Z5L, 1ZHB, 1ZHN, 2AKR, 2CKB, 2CLV, 2CLZ, 2FIK, 2FWO, 2GAZ, 2MHA, 2Q7Y, 2QRI, 2QRS, 2QRT, 2VAA, 2VAB, 2ZOK, 2ZOL, 2ZSV, 2ZSW, 3ARB, 3ARD, 3ARE, 3ARF, 3ARG, 3BUY, 3C8K, 3CCH, 3CPL, 3CVH, 3DMM, 3E6F, 3E6H, 3ECB, 3FOL, 3FOM, 3FON, 3FTG, 3GML, 3GMM, 3GMN, 3GMO, 3GMP, 3GMQ, 3GMR, 3ILP, 3ILQ, 3L3H, 3NWM, 3O8X, 3O9W, 3P4M, 3P4N, 3P4O, 3P9L, 3P9M, 3PAB, 3PQY, 3PWU, 3QUK, 3QUL, 3QUX, 3QUY, 3QUZ, 3RGV, 3ROL, 3ROO, 3RTQ, 3RUG, 3RZC, 3SCM, 3SDA, 3SDC, 3SDD, 3T1F, 3TBS, 3TBT, 3TBV, 3TBW, 3TBY, 3TVM, 3UBX, 4APQ, 4ELM, 4HUU, 4HUV, 4HUW, 4HUX, 4IHO, 4IRJ, 4IRS, 4L8B, 4L8C, 4L8D, 4MNG, 4NSK, 1BZ9, 1CD1, 1FG2, 1FO0, 1KJ2, 1KJ3, 1LD9, 1LK2, 1N59, 1QO3, 1RK0, 1RK1, 1U58, 1YN6, 1YN7, 1ZT1, 1ZT7, 2FO4, 2OL3, 2VE6, 3AU1, 3CC5, 3CH1, 3G08, 3HE6, 3HE7, 3MA7, 3QI9, 3TA3, 3TN0, 3TO4, 3VJ6, 4EI5, 4HV8, 4MQ7
Consensus CDS ProjectCCDS16654.1
International Mouse Knockout Project StatusB2m
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015534 VEGA Gene Model | MGI Sequence Detail 5398 C57BL/6J ±  kb
transcript OTTMUST00000036889 VEGA | MGI Sequence Detail 860 Not Applicable 
polypeptide OTTMUSP00000016550 VEGA | MGI Sequence Detail 119 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(3)
Polymorphisms All PCR and RFLP(23) : PCR(2) RFLP(21) SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015707 Beta-2-Microglobulin
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
Protein Ontology PR:000004580 beta-2-microglobulin
References (Earliest) J:1872 Tada N, et al., Ly-m11: the H-3 region of mouse chromosome 2 controls a new surface alloantigen. Immunogenetics. 1980;11(5):441-9
(Latest) J:206039 Chong SZ, et al., CD8 T Cells Regulate Allergic Contact Dermatitis by Modulating CCR2-Dependent TNF/iNOS-Expressing Ly6C(+)CD11b(+) Monocytic Cells. J Invest Dermatol. 2014 Mar;134(3):666-76
All references(773)
Other
accession IDs
MGD-MRK-12010, MGD-MRK-1492

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory