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B2m
Gene Detail
Symbol

Name
ID
B2m
beta-2 microglobulin
MGI:88127
Synonyms
beta2-m, beta 2 microglobulin, Ly-m11
Feature Type
protein coding gene
Genetic Map
Chromosome 2
60.55 cM, cytoband F1-F3
Detailed Genetic Map ± 1 cM


Mapping data(125)
Sequence Map
Chr2:122147686-122153083 bp, + strand
From VEGA annotation of GRCm38

  5398 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2987  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: B2m

Human
homologs
Human Homolog   B2M, beta-2-microglobulin
NCBI Gene ID 567
neXtProt AC  NX_P61769
Human Chr (Location)  15q21.1; chr15:44711487-44718159 (+)  GRCh38.p2
Disease Associations  (1) Diseases Associated with Human B2M
Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(26) Targeted(5) Transgenic(7)
 
Homozygotes lacking B2m appear normal, but have no detectable MHC class I antigen on their cells and are deficient in CD4- CD8+ T cells which mediate cytotoxic T cell function. Mutant mice are also subject to systemic iron loading.
 
Human Diseases Modeled in Mice Using B2m (1)    Mutations Annotated to Human Diseases (2)   
Interactions
B2m interacts with 93 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Expression
Literature Summary: (18 records)
Data Summary: Results (35)    Tissues (26)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RT-PCR 10
RNase protection 20
cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(57) Genomic(27) cDNA(21) Primer pair(5) Other(4)
Microarray probesets(5)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015534 VEGA Gene Model | MGI Sequence Detail 5398 C57BL/6J ±  kb
transcript OTTMUST00000036889 VEGA | MGI Sequence Detail 860 Not Applicable 
polypeptide OTTMUSP00000016550 VEGA | MGI Sequence Detail 119 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(3)
Polymorphisms
All PCR and RFLP(23) : PCR(2) RFLP(21) SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
Protein Ontology PR:000004580 beta-2-microglobulin
References
(Earliest) J:1872 Tada N, et al., Ly-m11: the H-3 region of mouse chromosome 2 controls a new surface alloantigen. Immunogenetics. 1980;11(5):441-9
(Latest) J:219556 Miyazaki M, et al., The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis. Genes Dev. 2015 Feb 15;29(4):409-25
All references(795)
Other
accession IDs
MGD-MRK-12010, MGD-MRK-1492

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory