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Gene Detail
beta-2 microglobulin
Synonyms beta2-m, beta 2 microglobulin, Ly-m11
Feature Type protein coding gene
Genetic Map
Chromosome 2
60.55 cM, cytoband F1-F3
Detailed Genetic Map ± 1 cM

Mapping data(125)
Sequence Map
Chr2:122147686-122153083 bp, + strand
From VEGA annotation of GRCm38

  5398 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:2987  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: B2m

Human Homolog B2M, beta-2-microglobulin
NCBI Gene ID 567
neXtProt AC  NX_P61769
Human Chr (Location)  15q21-q22.2; chr15:44711487-44718159 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human B2M
alleles, and
All mutations/alleles(31) : Gene trapped(26) Targeted(5)
Homozygotes lacking B2m appear normal, but have no detectable MHC class I antigen on their cells and are deficient in CD4- CD8+ T cells which mediate cytotoxic T cell function. Mutant mice are also subject to systemic iron loading.
Alleles Annotated to Human Diseases(1)   
B2m interacts with 93 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
All GO classifications: (23 annotations)
Process antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent, antigen processing and presentation of peptide antigen via MHC class I, ...
Component cytoplasm, external side of plasma membrane, ...
Function identical protein binding, protein binding
External Resources: FuncBase
Literature Summary: (17 records)
Data Summary: Results (35)    Tissues (26)   
Theiler Stages: 1, 2, 3, 4, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 5
RNase protection 20
cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(57) Genomic(27) cDNA(21) Primer pair(5) Other(4)
Microarray probesets(5)
Other database
VEGA Gene ModelOTTMUSG00000015534 (Evidence)
Ensembl Gene ModelENSMUSG00000060802 (Evidence)
Entrez Gene12010 (Evidence)
NIA Mouse Gene IndexU002368
PDB1BII, 1BQH, 1DDH, 1FFN, 1FFO, 1FFP, 1FZJ, 1FZK, 1FZM, 1FZO, 1G6R, 1G7P, 1G7Q, 1HOC, 1INQ, 1JPF, 1JPG, 1JUF, 1K8D, 1KBG, 1KPU, 1KPV, 1L6Q, 1LDP, 1LEG, 1LEK, 1MHC, 1MWA, 1N3N, 1N5A, 1NAM, 1NAN, 1NEZ, 1OSZ, 1P1Z, 1P4L, 1PQZ, 1RJY, 1RJZ, 1S7Q, 1S7R, 1S7S, 1S7T, 1S7U, 1S7V, 1S7W, 1S7X, 1T0M, 1T0N, 1VAC, 1VAD, 1WBX, 1WBY, 1WBZ, 1Z5L, 1ZHB, 1ZHN, 2AKR, 2CKB, 2CLV, 2CLZ, 2FIK, 2FWO, 2GAZ, 2MHA, 2Q7Y, 2QRI, 2QRS, 2QRT, 2VAA, 2VAB, 2ZOK, 2ZOL, 2ZSV, 2ZSW, 3ARB, 3ARD, 3ARE, 3ARF, 3ARG, 3BUY, 3C8K, 3CCH, 3CPL, 3CVH, 3DMM, 3E6F, 3E6H, 3ECB, 3FOL, 3FOM, 3FON, 3FTG, 3GML, 3GMM, 3GMN, 3GMO, 3GMP, 3GMQ, 3GMR, 3ILP, 3ILQ, 3L3H, 3NWM, 3O8X, 3O9W, 3P4M, 3P4N, 3P4O, 3P9L, 3P9M, 3PAB, 3PQY, 3PWU, 3QUK, 3QUL, 3QUX, 3QUY, 3QUZ, 3RGV, 3ROL, 3ROO, 3RTQ, 3RUG, 3RZC, 3SCM, 3SDA, 3SDC, 3SDD, 3T1F, 3TBS, 3TBT, 3TBV, 3TBW, 3TBY, 3TVM, 3UBX, 4APQ, 4ELM, 4HUU, 4HUV, 4HUW, 4HUX, 4IHO, 4IRJ, 4IRS, 4L8B, 4L8C, 4L8D, 4MNG, 4NSK, 1BZ9, 1CD1, 1FG2, 1FO0, 1KJ2, 1KJ3, 1LD9, 1LK2, 1N59, 1QO3, 1RK0, 1RK1, 1U58, 1YN6, 1YN7, 1ZT1, 1ZT7, 2FO4, 2OL3, 2VE6, 3AU1, 3CC5, 3CH1, 3G08, 3HE6, 3HE7, 3MA7, 3QI9, 3TA3, 3TN0, 3TO4, 3VJ6, 3WS3, 3WS6, 4EI5, 4HS3, 4HV8, 4MQ7, 4PV8, 4PV9
Consensus CDS ProjectCCDS16654.1
International Mouse Knockout Project StatusB2m
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015534 VEGA Gene Model | MGI Sequence Detail 5398 C57BL/6J ±  kb
transcript OTTMUST00000036889 VEGA | MGI Sequence Detail 860 Not Applicable 
polypeptide OTTMUSP00000016550 VEGA | MGI Sequence Detail 119 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(3)
Polymorphisms All PCR and RFLP(23) : PCR(2) RFLP(21) SNPs within 2kb(53 from dbSNP Build 137)
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
Protein Ontology PR:000004580 beta-2-microglobulin
References (Earliest) J:1872 Tada N, et al., Ly-m11: the H-3 region of mouse chromosome 2 controls a new surface alloantigen. Immunogenetics. 1980;11(5):441-9
(Latest) J:212091 Ross JO, et al., Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2550-8
All references(786)
accession IDs
MGD-MRK-12010, MGD-MRK-1492

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory