B2m Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

B2m
beta-2 microglobulin
MGI:88127

33 phenotypes from 3 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
B2m^{tm1b(EUCOMM)Wtsi}/B2m⁺ C57BL/6N-B2m^{tm1b(EUCOMM)Wtsi}/Tcp	abnormal skin morphology	J:211773
	hydrometra	J:211773
	increased circulating phosphate level	J:211773
	small superior vagus ganglion	J:211773
B2m^{tm1b(EUCOMM)Wtsi}/B2m^{tm1b(EUCOMM)Wtsi} C57BL/6N-B2m^{tm1b(EUCOMM)Wtsi}/Tcp	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
	preweaning lethality, incomplete penetrance	J:211773
B2m^tm1Jae/B2m^tm1Jae B6.129S2-B2m^tm1Jae	abnormal lateral geniculate nucleus morphology	J:66246
	decreased interleukin-4 secretion	J:64283
	decreased susceptibility to parasitic infection	J:64283
	increased interleukin-3 secretion	J:64283
	increased tumor necrosis factor secretion	J:64283
B2m^tm1Jae/B2m^tm1Jae involves: 129S2/SvPas	decreased CD8-positive, alpha-beta T cell number	J:166104
B2m^tm1Jae/B2m^tm1Jae involves: 129S2/SvPas	hemochromatosis	J:17527
B2m^tm1Jae/B2m^tm1Jae involves: 129S2/SvPas * C57BL/6J	abnormal CD8-positive, alpha-beta cytotoxic T cell morphology	J:80910
	abnormal cytotoxic T cell physiology	J:80910
	decreased CD8-positive, alpha-beta T cell number	J:744, J:80910
	increased gamma-delta intraepithelial T cell number	J:744
	increased gamma-delta T cell number	J:744
B2m^tm1Unc/B2m⁺ involves: 129P2/OlaHsd * C57BL/6	decreased CD8-positive, alpha-beta T cell number	J:64451
B2m^tm1Unc/B2m⁺ involves: 129P2/OlaHsd * C57BL/6	decreased level of surface class I molecules	J:64451
B2m^tm1Unc/B2m^tm1Unc B6.129P2-B2m^tm1Unc/DcrJ	abnormal interleukin level	J:123934
	abnormal pancreas morphology	J:135214
	abnormal tumor necrosis factor level	J:123934
	decreased CD8-positive, alpha-beta T cell number	J:123934
	decreased circulating serum albumin level	J:110885
	decreased IgG level	J:110885
	decreased susceptibility to autoimmune diabetes	J:135214
	decreased susceptibility to bacterial infection	J:123934
	increased IgM level	J:110885
	increased susceptibility to infection induced morbidity/mortality	J:123934
	increased T-helper 1 cell number	J:123934
B2m^tm1Unc/B2m^tm1Unc involves: 129P2/OlaHsd * C57BL/6	abnormal T cell number	J:113083
	absent CD8-positive, alpha-beta T cells	J:64451
	decreased level of surface class I molecules	J:64451
B2m^tm1Unc/B2m^tm1Unc involves: 129P2/OlaHsd * NOD/Lt	insulitis	J:93557
B2m^tm1Unc/B2m^tm1Unc NOD.129P2-B2m^tm1Unc	abnormal pancreatic beta cell morphology	J:17000
	absent CD8-positive, alpha-beta T cells	J:121685
	decreased susceptibility to autoimmune diabetes	J:17000, J:121685

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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