Phenotypes Associated with This Genotype

Genotype
MGI:3576233

• Allelic Composition: B2m^tm1Jae/B2m^tm1Jae
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

hemochromatosis ( J:17527 )

• abnormal deposits of ferric iron in liver and increased total hepatic iron levels (1583 ug/g dry tissue vs. 468 ug/g in wildtype)

• occasionally saw deposits of ferric iron in myocytes, in the branchial wall and lumen of the lung, in the pancreas, and in 5 week old marginal zone of the spleen

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:166104 )

• in the spleen and thymus

immune system

decreased CD8-positive, alpha-beta T cell number ( J:166104 )

• in the spleen and thymus

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hemochromatosis		DOID:2352	OMIM:231100 OMIM:PS235200	J:17527